中华传染病杂志
中華傳染病雜誌
중화전염병잡지
CHINESE JOURNAL OF INFECTIOUS DISEASES
2014年
4期
219-224
,共6页
冼慧霞%陈龙%罗敏%姚相杰%杨洪%贺连华%张海龙%何雅青
冼慧霞%陳龍%囉敏%姚相傑%楊洪%賀連華%張海龍%何雅青
승혜하%진룡%라민%요상걸%양홍%하련화%장해룡%하아청
手足口病%肠道病毒A型,人%基因,病毒%序列分析%流行病学研究
手足口病%腸道病毒A型,人%基因,病毒%序列分析%流行病學研究
수족구병%장도병독A형,인%기인,병독%서렬분석%류행병학연구
Hand,foot and mouth disease%Enterovirus A,human%Genes,viral%Sequence analysis%Epidemiologic studies
目的 了解2010年至2012年深圳市手足口病病原构成、分子特征和流行病学规律,为制订防制措施提供科学依据.方法 收集2010年至2012年深圳市手足口病疑似患者粪便或肛拭子标本1 523份,实时荧光定量PCR和反转录半套式PCR (RT-snPCR)法进行VP1基因系统进化分析,数据分析行x2检验.结果 手足口病发病以2岁以下儿童居多,其次为2~3岁组;宝安和龙岗区患者数最多;各年龄组性别比较差异有统计学意义(x2=12.365,P=0.030).2010年至2012年1 523例手足口病患者病原学分析,肠道病毒阳性1 148例,占75.4%,包括肠道病毒71型(EV71)、柯萨奇病毒(Cox)A组和B组、埃可病毒等28种病原;居前4位分别为EV71 (57.1%)、CoxA6(18.5%)、CoxA16 (14.0%)和CoxA10(3.7%),以A组人肠道病毒(HEV-A)最为普遍(96.2%).深圳市CoxA6毒株与2008年芬兰、2010年法国和2011年日本毒株亲缘性较近,CoxA10与2007年斯洛伐克、2008年西班牙毒株同源性最高.结论 2010年至2012年深圳市手足口病病原谱以HEV-A组的EV71、CoxA6、CoxA16和CoxA10为主,CoxA6是继EV71之后的第2位主要病原体,深圳市CoxA6毒株可能起源于欧洲和日本.位于深圳北部的宝安区和龙岗区是手足口病的主要分布地区;<2岁是手足口病高发年龄段.
目的 瞭解2010年至2012年深圳市手足口病病原構成、分子特徵和流行病學規律,為製訂防製措施提供科學依據.方法 收集2010年至2012年深圳市手足口病疑似患者糞便或肛拭子標本1 523份,實時熒光定量PCR和反轉錄半套式PCR (RT-snPCR)法進行VP1基因繫統進化分析,數據分析行x2檢驗.結果 手足口病髮病以2歲以下兒童居多,其次為2~3歲組;寶安和龍崗區患者數最多;各年齡組性彆比較差異有統計學意義(x2=12.365,P=0.030).2010年至2012年1 523例手足口病患者病原學分析,腸道病毒暘性1 148例,佔75.4%,包括腸道病毒71型(EV71)、柯薩奇病毒(Cox)A組和B組、埃可病毒等28種病原;居前4位分彆為EV71 (57.1%)、CoxA6(18.5%)、CoxA16 (14.0%)和CoxA10(3.7%),以A組人腸道病毒(HEV-A)最為普遍(96.2%).深圳市CoxA6毒株與2008年芬蘭、2010年法國和2011年日本毒株親緣性較近,CoxA10與2007年斯洛伐剋、2008年西班牙毒株同源性最高.結論 2010年至2012年深圳市手足口病病原譜以HEV-A組的EV71、CoxA6、CoxA16和CoxA10為主,CoxA6是繼EV71之後的第2位主要病原體,深圳市CoxA6毒株可能起源于歐洲和日本.位于深圳北部的寶安區和龍崗區是手足口病的主要分佈地區;<2歲是手足口病高髮年齡段.
목적 료해2010년지2012년심수시수족구병병원구성、분자특정화류행병학규률,위제정방제조시제공과학의거.방법 수집2010년지2012년심수시수족구병의사환자분편혹항식자표본1 523빈,실시형광정량PCR화반전록반투식PCR (RT-snPCR)법진행VP1기인계통진화분석,수거분석행x2검험.결과 수족구병발병이2세이하인동거다,기차위2~3세조;보안화룡강구환자수최다;각년령조성별비교차이유통계학의의(x2=12.365,P=0.030).2010년지2012년1 523례수족구병환자병원학분석,장도병독양성1 148례,점75.4%,포괄장도병독71형(EV71)、가살기병독(Cox)A조화B조、애가병독등28충병원;거전4위분별위EV71 (57.1%)、CoxA6(18.5%)、CoxA16 (14.0%)화CoxA10(3.7%),이A조인장도병독(HEV-A)최위보편(96.2%).심수시CoxA6독주여2008년분란、2010년법국화2011년일본독주친연성교근,CoxA10여2007년사락벌극、2008년서반아독주동원성최고.결론 2010년지2012년심수시수족구병병원보이HEV-A조적EV71、CoxA6、CoxA16화CoxA10위주,CoxA6시계EV71지후적제2위주요병원체,심수시CoxA6독주가능기원우구주화일본.위우심수북부적보안구화룡강구시수족구병적주요분포지구;<2세시수족구병고발년령단.
Objective To investigate the pathogen spectrum and molecular epidemiological characteristics of hand,foot and mouth disease (HFMD) in Shenzhen from 2010 to 2012 and to provide scientific basis for HFMD control.Methods A total of 1 523 clinical stool specimens or anal swab from the sentinel surveillance systems of HFMD were obtained.Molecular evolutions of VP1 gene of causative agents were detected by real-time fluorescence quantitative polymerase chain reaction (PCR) and reverse transcription semi nested PCR(RT-snPCR),which analyzed the molecular evolution of VP1.The data were analyzed by chi-square test.Results Children under two years old were in high incidence of HFMD,followed by 2-3 years old group.The largest number of HFMD cases from 2010 to 2012 was in Baoan and Longgang districts.There were significant differences between male and female among all age groups (x2=12.365,P=0.030).Totally 1 148 of 1 523 (75.4%) HFMDcases from 2010 to 2012 were found positive for human enterovirus and twenty-eight different genotypes were detected,including Enterovirus (EV71)71,Coxsakievirus (Cox) group A and B,and Echovirus.EV71 (57.1%),CoxA6 (18.5%),CoxA16 (14.0%) and CoxA10 (3.7%) were the top four pathogens,enterovirus group A was the most common (96.2%).CoxA6 strains isolated from Shenzhen were genetically related to those from Finland 2008,France 2010 and Japan 2011,Shenzhen CoxA10 strains showed closest genetic relationship to Slovakia 2007 and Spain 2008.Conclusions The pathogen spectrum of Shenzhen HFMD from 2010 to 2012 are EV71,CoxA6,CoxA16 and CoxA10.The prevalence of Shenzhen CoxA6 ranks second major pathogen of HFMD which may be originated from European countries and Japan.Baoan and Longgang district,locate in the north of Shenzhen are the main distribution area.High incidence of HFMD is 1-2 years old group.