中华传染病杂志
中華傳染病雜誌
중화전염병잡지
CHINESE JOURNAL OF INFECTIOUS DISEASES
2014年
6期
357-363
,共7页
耿红%李永文%李新旭%王志萍%陶武威%于春宝
耿紅%李永文%李新旭%王誌萍%陶武威%于春寶
경홍%리영문%리신욱%왕지평%도무위%우춘보
分枝杆菌,结核%结核病%寡核苷酸序列分析%Meta分析
分枝桿菌,結覈%結覈病%寡覈苷痠序列分析%Meta分析
분지간균,결핵%결핵병%과핵감산서렬분석%Meta분석
Mycobacterium tuberculosis%Tuberculosis%Oligonucleotide array sequence analysis%Meta-analysis
目的 评价中国开展基因芯片检测结核分枝杆菌(MTB)对异烟肼和利福平耐药性的诊断效果.方法 通过检索PubMed数据库、Science Direct数据库、中国生物医学文献光盘数据库、中国期刊全文数据库和万方数据库,收集1995年1月至2013年6月发表的在中国开展基因芯片检测MTB对异烟肼和利福平耐药性的相关文献,使用Meta-Disc1.4软件进行分析.结果 共检索到中、英文文献618篇,其中15篇纳入本研究,发表时间为2004年至2013年.Meta分析结果显示,基因芯片检测MTB对异烟肼耐药性的总灵敏度为0.79(95％CI为0.77～0.81),特异度为0.94(95％CI为0.93～0.95),曲线下面积(AUC)为0.86;检测利福平的总灵敏度为0.91(95％CI为0.89～0.92),特异度为0.96(95％CI为0.96～0.97),AUC为0.97;诊断耐多药MTB的总灵敏度为0.75(95％CI为0.72～0.78),特异度为0.97(95％CI为0.96～0.98).结论 中国开展基因芯片检测MTB对异烟肼耐药性的检测效能中等,对利福平耐药性的检测效果较好;基因芯片检测耐多药MTB的诊断价值尚需进一步研究.
目的 評價中國開展基因芯片檢測結覈分枝桿菌(MTB)對異煙肼和利福平耐藥性的診斷效果.方法 通過檢索PubMed數據庫、Science Direct數據庫、中國生物醫學文獻光盤數據庫、中國期刊全文數據庫和萬方數據庫,收集1995年1月至2013年6月髮錶的在中國開展基因芯片檢測MTB對異煙肼和利福平耐藥性的相關文獻,使用Meta-Disc1.4軟件進行分析.結果 共檢索到中、英文文獻618篇,其中15篇納入本研究,髮錶時間為2004年至2013年.Meta分析結果顯示,基因芯片檢測MTB對異煙肼耐藥性的總靈敏度為0.79(95％CI為0.77～0.81),特異度為0.94(95％CI為0.93～0.95),麯線下麵積(AUC)為0.86;檢測利福平的總靈敏度為0.91(95％CI為0.89～0.92),特異度為0.96(95％CI為0.96～0.97),AUC為0.97;診斷耐多藥MTB的總靈敏度為0.75(95％CI為0.72～0.78),特異度為0.97(95％CI為0.96～0.98).結論 中國開展基因芯片檢測MTB對異煙肼耐藥性的檢測效能中等,對利福平耐藥性的檢測效果較好;基因芯片檢測耐多藥MTB的診斷價值尚需進一步研究.
목적 평개중국개전기인심편검측결핵분지간균(MTB)대이연정화리복평내약성적진단효과.방법 통과검색PubMed수거고、Science Direct수거고、중국생물의학문헌광반수거고、중국기간전문수거고화만방수거고,수집1995년1월지2013년6월발표적재중국개전기인심편검측MTB대이연정화리복평내약성적상관문헌,사용Meta-Disc1.4연건진행분석.결과 공검색도중、영문문헌618편,기중15편납입본연구,발표시간위2004년지2013년.Meta분석결과현시,기인심편검측MTB대이연정내약성적총령민도위0.79(95％CI위0.77～0.81),특이도위0.94(95％CI위0.93～0.95),곡선하면적(AUC)위0.86;검측리복평적총령민도위0.91(95％CI위0.89～0.92),특이도위0.96(95％CI위0.96～0.97),AUC위0.97;진단내다약MTB적총령민도위0.75(95％CI위0.72～0.78),특이도위0.97(95％CI위0.96～0.98).결론 중국개전기인심편검측MTB대이연정내약성적검측효능중등,대리복평내약성적검측효과교호;기인심편검측내다약MTB적진단개치상수진일보연구.
Objective To evaluate the effect of genechip in detecting isoniazid-and rifampicinresistance of Mycobacterium tuberculosis (MTB) in China.Methods Studies of genechip in detecting MTB resistance to isoniazid and rifampicin in China,which were published from January 1995 to June 2013,were identified through searches of PubMed,Science Direct,CBMDISC,CNKI and Wanfang database.Meta-Disc1.4 software was used for all analyses.Results Totally 618 articles were identified.Fifteen articles published from 2004 to 2013 were finally included in the study.The pooled sensitivity and specificity of genechip in detecting MTB resistance to isoniazid was 0.79 (95 ％CI:0.77-0.81) and 0.94 (95％CI:0.93-0.95),respectively,with the area under curve (AUC) of 0.86.The pooled sensitivity and specificity of genechip in detecting MTB resistance to rifampin was 0.91 (95％CI:0.89-0.92) and 0.96 (95％CI:0.96-0.97),respectively,with the AUC of 0.97.The pooled sensitivity and specificity of genechip in detecting MTB resistance to multidrug was 0.75 (95％CI:0.72-0.78) and 0.97 (95％ CI:0.96-0.98),respectively.Conclusions The effect of genechip in detecting MTB resistance is moderate for isoniazid,while better for rifampin in China.More studies are needed to evaluate the effect of genechip in detecting multidrug resistance in MTB.
