中华创伤杂志
中華創傷雜誌
중화창상잡지
Chinese Journal of Traumatology
2012年
10期
881-884
,共4页
烧伤%感染%血小板
燒傷%感染%血小闆
소상%감염%혈소판
Burns%Infection%Blood platelets
目的 探讨烧伤和烧伤感染患者血小板微粒( platelet microparticles,PMPs)的变化及临床意义. 方法 选择烧伤休克期组(44例)、烧伤感染组(33例)和对照组(11例)患者,用流式细胞仪等方法检测血浆中PMPs水平,以绝对值和所占细胞微粒比例表示,同时检测临床常用生化指标,并分析与PMPs的相关性. 结果 烧伤休克期组和烧伤感染组CD41+ PMPs水平高于对照组(P＜0.01),且与烧伤面积呈正相关(r =0.258,P＜0.05).多元逐步回归分析进入CD41+ PMPs水平回归方程的有γ-谷氨酰转肽酶(γ-GT)、烧伤面积和谷丙转氨酶(ALT).结论 烧伤患者PMPs水平升高可能与烧伤后凝血状态密切相关.
目的 探討燒傷和燒傷感染患者血小闆微粒( platelet microparticles,PMPs)的變化及臨床意義. 方法 選擇燒傷休剋期組(44例)、燒傷感染組(33例)和對照組(11例)患者,用流式細胞儀等方法檢測血漿中PMPs水平,以絕對值和所佔細胞微粒比例錶示,同時檢測臨床常用生化指標,併分析與PMPs的相關性. 結果 燒傷休剋期組和燒傷感染組CD41+ PMPs水平高于對照組(P＜0.01),且與燒傷麵積呈正相關(r =0.258,P＜0.05).多元逐步迴歸分析進入CD41+ PMPs水平迴歸方程的有γ-穀氨酰轉肽酶(γ-GT)、燒傷麵積和穀丙轉氨酶(ALT).結論 燒傷患者PMPs水平升高可能與燒傷後凝血狀態密切相關.
목적 탐토소상화소상감염환자혈소판미립( platelet microparticles,PMPs)적변화급림상의의. 방법 선택소상휴극기조(44례)、소상감염조(33례)화대조조(11례)환자,용류식세포의등방법검측혈장중PMPs수평,이절대치화소점세포미립비례표시,동시검측림상상용생화지표,병분석여PMPs적상관성. 결과 소상휴극기조화소상감염조CD41+ PMPs수평고우대조조(P＜0.01),차여소상면적정정상관(r =0.258,P＜0.05).다원축보회귀분석진입CD41+ PMPs수평회귀방정적유γ-곡안선전태매(γ-GT)、소상면적화곡병전안매(ALT).결론 소상환자PMPs수평승고가능여소상후응혈상태밀절상관.
Objective To investigate the clinical significance of changes of platelet microparticles (PMPs) in burn and burn infection patients.Methods The patients were divided into burn shock group (n =44),burn infection group (n =33) and control group (n =11 ).Plasma PMPs were determined by flow cytometry and were recorded in absolute value and in particle proportion.Also,the frequently used biochemical indicators were detected and analyzed for their relationship with PMPs.Results CD41 + PMPs levels in the burn shock and burn infection groups were higher than those in the control group (P ＜ 0.01 ) and they showed positive relation with extent of burn ( r =0.258,P ＜ 0.05 ).Stepwise regression analysis indicated that r-glutamyltranspeptidase (r-GT),extent of burn and alanine aminotransferase (ALT) entered CD41 + PMPs level regression equation.Conclusion The increase of PMPs levels may be closely correlated with the pathological coagulation state in severe burn patients.
