中华创伤杂志
中華創傷雜誌
중화창상잡지
Chinese Journal of Traumatology
2013年
1期
21-24
,共4页
马辉%张涛%郭尚林%夏鹤春%孙胜玉%田秋恩%王喜龙%孙晓川
馬輝%張濤%郭尚林%夏鶴春%孫勝玉%田鞦恩%王喜龍%孫曉川
마휘%장도%곽상림%하학춘%손성옥%전추은%왕희룡%손효천
创伤性蛛网膜下腔出血%脑血管痉挛%血管内皮生长因子
創傷性蛛網膜下腔齣血%腦血管痙攣%血管內皮生長因子
창상성주망막하강출혈%뇌혈관경련%혈관내피생장인자
Traumatic subarachnoid hemorrhage%Cerebral vasospasm%Vascular endothelial growth factor
目的 研究创伤性蛛网膜下腔出血(traumatic subarachnoid hemorrhage,tSAH)患者血清血管内皮生长因子(vascular endothelial growth factor,VEGF)水平变化与脑血管痉挛(cerebral vasospasm,CVS)及其严重程度的动态相关性. 方法 收集48例tSAH患者,进行CT影像评估,采用经颅多普勒(TCD)动态检测患者伤后1,3,5,7,10,15 d大脑中动脉流速,并进行临床分级.采集患者静脉血,通过ELISA法测定患者伤后1,3,5,7,10,15d静脉血清中VEGF水平；分析患者血清VEGF水平变化与CVS严重程度的动态相关性.同时纳入10名健康志愿者作为对照组.结果 发生CVS的患者血清中VEGF水平明显高于未发生CVS的患者,也明显高于对照组的健康志愿者.其中,重度CVS患者血清VEGF表达水平持续增高. 结论 血清VEGF水平的动态变化可反映tSAH后CVS的严重程度,可为早期诊断CVS提供依据.
目的 研究創傷性蛛網膜下腔齣血(traumatic subarachnoid hemorrhage,tSAH)患者血清血管內皮生長因子(vascular endothelial growth factor,VEGF)水平變化與腦血管痙攣(cerebral vasospasm,CVS)及其嚴重程度的動態相關性. 方法 收集48例tSAH患者,進行CT影像評估,採用經顱多普勒(TCD)動態檢測患者傷後1,3,5,7,10,15 d大腦中動脈流速,併進行臨床分級.採集患者靜脈血,通過ELISA法測定患者傷後1,3,5,7,10,15d靜脈血清中VEGF水平；分析患者血清VEGF水平變化與CVS嚴重程度的動態相關性.同時納入10名健康誌願者作為對照組.結果 髮生CVS的患者血清中VEGF水平明顯高于未髮生CVS的患者,也明顯高于對照組的健康誌願者.其中,重度CVS患者血清VEGF錶達水平持續增高. 結論 血清VEGF水平的動態變化可反映tSAH後CVS的嚴重程度,可為早期診斷CVS提供依據.
목적 연구창상성주망막하강출혈(traumatic subarachnoid hemorrhage,tSAH)환자혈청혈관내피생장인자(vascular endothelial growth factor,VEGF)수평변화여뇌혈관경련(cerebral vasospasm,CVS)급기엄중정도적동태상관성. 방법 수집48례tSAH환자,진행CT영상평고,채용경로다보륵(TCD)동태검측환자상후1,3,5,7,10,15 d대뇌중동맥류속,병진행림상분급.채집환자정맥혈,통과ELISA법측정환자상후1,3,5,7,10,15d정맥혈청중VEGF수평；분석환자혈청VEGF수평변화여CVS엄중정도적동태상관성.동시납입10명건강지원자작위대조조.결과 발생CVS적환자혈청중VEGF수평명현고우미발생CVS적환자,야명현고우대조조적건강지원자.기중,중도CVS환자혈청VEGF표체수평지속증고. 결론 혈청VEGF수평적동태변화가반영tSAH후CVS적엄중정도,가위조기진단CVS제공의거.
Objective To investigate dynamic relation of serum levels of vascular endothelial growth factor (VEGF) with occurrence and severity of cerebral vasospasm (CVS) in patients with traumatic subarachnoid hemorrhage (tSAH).Methods Forty-eight patients with tSAH were involved in the study.All the patients received CT imaging assessment.All patients received TCD dynamic monitoring of flow velocity of middle cerebral artery at days 1,3,5,7,10 and 15 after admission for clinical classification of CVS.The venous blood samples were obtained to determine VEGF levels in the serum by ELISA at days 1,3,5,7,10 and 15 after admission and dynamic relationship between CVS severity and serum VEGF was evaluated.Ten normal volunteers were included as the control group.Results Serum levels of VEGF in patients with secondary CVS were significantly higher than those without CVS and normal volunteers in the control group.Additionally,expression levels of VEGF in the serum kept persistent increase in patients with severe CVS.Conclusion Dynamic variation of serum VEGF levels in patients with tSAH may be an indicator of CVS severity and hence may provide a basis for early diagnosis of CVS.
