CAJ | 학술논문

目的验证影响糖尿病足溃疡(diabetic foot ulcer,DFU)预后的相关因素. 方法本前瞻性研究共纳入来自单一糖尿病足中心的186例Ⅱ型DFU患者,6个月内随访结局(愈合、大截肢、死亡).通过Logistic多元回归分析DFU患者的人口学和临床资料与DFU结局之间的关系.结果随访172例DFU患者,其中147例愈合(包括55例小截肢后愈合),3例大截肢,6例死亡,16例在研究结束时仍未愈合.Logistic多元回归分析表明,缺血(P＜0.01)、感染(P＜0.05)、溃疡数目(P＜0.01)、周围神经病变(P＜0.05)可独立影响DFU结局;缺血[优势比(odds ratio,OR)=10.8]、感染(OR =211.4)、溃疡数目(OR =39.5)、周围神经病变(OR=181.1)增加DFU不良结局的风险. 结论 DFU的预后与缺血、感染、溃疡数目和周围神经病变有关.
목적 험증영향당뇨병족궤양(diabetic foot ulcer,DFU)예후적상관인소. 방법 본전첨성연구공납입래자단일당뇨병족중심적186례Ⅱ형DFU환자,6개월내수방결국(유합、대절지、사망).통과Logistic다원회귀분석DFU환자적인구학화림상자료여DFU결국지간적관계.결과 수방172례DFU환자,기중147례유합(포괄55례소절지후유합),3례대절지,6례사망,16례재연구결속시잉미유합.Logistic다원회귀분석표명,결혈(P＜0.01)、감염(P＜0.05)、궤양수목(P＜0.01)、주위신경병변(P＜0.05)가독립영향DFU결국;결혈[우세비(odds ratio,OR)=10.8]、감염(OR =211.4)、궤양수목(OR =39.5)、주위신경병변(OR=181.1)증가DFU불량결국적풍험. 결론 DFU적예후여결혈、감염、궤양수목화주위신경병변유관.
Objective To identify the factors related to prognosis of diabetic foot ulcer (DFU).Methods A total of 186 patients with type Ⅱ DFU from a single diabetic foot center was included in this prospective study.Follow-up of the final outcome (healing,major amputation or death) was made in 6 months.Influence of patient demographics and clinical data on outcome was detected using multivariate Logistic regression analysis.Results Follow-up was performed in 172 patients,of whom 147 were cured (55 cases cured after minor amputations),3 underwent major amputations,6 died,and 16 were not yet cured at the final follow-up.In multivariate Logistic regression analysis,the outcome was independently correlated with ischemia (P ＜0.01),infection (P ＜ 0.05),ulcer number (P ＜ 0.01) and peripheral neuropathy (P ＜ 0.05) ; the risk of poor outcome increased with ischemia [odds ratio (OR) =10.8],infection (OR =211.4),ulcer number (OR =39.5),and peripheral neuropathy (OR =181.1).Conclusion Prognosis of DFU is associated with ischemia,infection,ulcer number,and peripheral neuropathy.