中华超声影像学杂志
中華超聲影像學雜誌
중화초성영상학잡지
CHINESE JOURNAL OF ULTRASONOGRAPHY
2012年
11期
973-976
,共4页
游珊珊%姜玉新%朱庆莉%孝梦甦%王红燕%张景%刘赫%戴晴
遊珊珊%薑玉新%硃慶莉%孝夢甦%王紅燕%張景%劉赫%戴晴
유산산%강옥신%주경리%효몽소%왕홍연%장경%류혁%대청
超声检查%乳腺疾病%光散射断层成像
超聲檢查%乳腺疾病%光散射斷層成像
초성검사%유선질병%광산사단층성상
Ultrasonography%Breast diseases%Diffused optical tomography
目的 利用超声光散射断层成像(DOT)研究乳腺病灶的血红蛋白浓度(THC),探讨不同大小乳腺病灶的THC最佳诊断阈值.方法 以进行乳腺病变切除活检术的500个病灶为研究对象,以术后病理结果作为金标准,比较两组不同大小良性病灶间及恶性病灶间THC差异、最佳诊断阈值及诊断效能.结果 共500个乳腺病灶,其中良性病灶265个,恶性病灶235个.＜2 cm组和≥2 cm组的恶性病灶THC均值分别为(193.0±81.3)μmol/L,(249.3±73.6)μmol/L,恶性病灶两组间THC差异有统计学意义(P=0.000);＜2 cm组和≥2 cm组的良性病灶THC均值分别为(117.8±62.0)μmol/L,(131.8±70.0)μmol/L,良性病灶两组间THC差异无统计学意义(P=0.13)；对＜2 cm组的病灶,分别以THC146.9 μmol/L,102.2μmol/L为鉴别诊断阈值,DOT的敏感性、特异性、准确性、阳性预测值、阴性预测值分别为74.2％,70.0％,71.7％,62.9％,79.9％和86.7％,44.4％,61.6％,51.6％,83％.对≥2 cm组的病灶,以THC 210.4μmol/L为诊断阈值,DOT的敏感性、特异性、准确性、阳性预测值、阴性预测值分别为74.0％,86.7％,79.1％,89.2％,69.2％.结论 乳腺癌的THC随肿瘤增大而增高,故应采用不同的THC诊断阈值来提高诊断的敏感性、特异性及准确性.
目的 利用超聲光散射斷層成像(DOT)研究乳腺病竈的血紅蛋白濃度(THC),探討不同大小乳腺病竈的THC最佳診斷閾值.方法 以進行乳腺病變切除活檢術的500箇病竈為研究對象,以術後病理結果作為金標準,比較兩組不同大小良性病竈間及噁性病竈間THC差異、最佳診斷閾值及診斷效能.結果 共500箇乳腺病竈,其中良性病竈265箇,噁性病竈235箇.＜2 cm組和≥2 cm組的噁性病竈THC均值分彆為(193.0±81.3)μmol/L,(249.3±73.6)μmol/L,噁性病竈兩組間THC差異有統計學意義(P=0.000);＜2 cm組和≥2 cm組的良性病竈THC均值分彆為(117.8±62.0)μmol/L,(131.8±70.0)μmol/L,良性病竈兩組間THC差異無統計學意義(P=0.13)；對＜2 cm組的病竈,分彆以THC146.9 μmol/L,102.2μmol/L為鑒彆診斷閾值,DOT的敏感性、特異性、準確性、暘性預測值、陰性預測值分彆為74.2％,70.0％,71.7％,62.9％,79.9％和86.7％,44.4％,61.6％,51.6％,83％.對≥2 cm組的病竈,以THC 210.4μmol/L為診斷閾值,DOT的敏感性、特異性、準確性、暘性預測值、陰性預測值分彆為74.0％,86.7％,79.1％,89.2％,69.2％.結論 乳腺癌的THC隨腫瘤增大而增高,故應採用不同的THC診斷閾值來提高診斷的敏感性、特異性及準確性.
목적 이용초성광산사단층성상(DOT)연구유선병조적혈홍단백농도(THC),탐토불동대소유선병조적THC최가진단역치.방법 이진행유선병변절제활검술적500개병조위연구대상,이술후병리결과작위금표준,비교량조불동대소량성병조간급악성병조간THC차이、최가진단역치급진단효능.결과 공500개유선병조,기중량성병조265개,악성병조235개.＜2 cm조화≥2 cm조적악성병조THC균치분별위(193.0±81.3)μmol/L,(249.3±73.6)μmol/L,악성병조량조간THC차이유통계학의의(P=0.000);＜2 cm조화≥2 cm조적량성병조THC균치분별위(117.8±62.0)μmol/L,(131.8±70.0)μmol/L,량성병조량조간THC차이무통계학의의(P=0.13)；대＜2 cm조적병조,분별이THC146.9 μmol/L,102.2μmol/L위감별진단역치,DOT적민감성、특이성、준학성、양성예측치、음성예측치분별위74.2％,70.0％,71.7％,62.9％,79.9％화86.7％,44.4％,61.6％,51.6％,83％.대≥2 cm조적병조,이THC 210.4μmol/L위진단역치,DOT적민감성、특이성、준학성、양성예측치、음성예측치분별위74.0％,86.7％,79.1％,89.2％,69.2％.결론 유선암적THC수종류증대이증고,고응채용불동적THC진단역치래제고진단적민감성、특이성급준학성.
Objective To measure total hemoglobin concentration (THC) of breast lesion using US-guided diffused optical tomography(DOT) and to investigate the THC optimal threshold value in different size breast lesions.Methods DOT was performed on 500 breast lesions and surgical pathology was as the gold standard.The optimal diagnostic threshold and the efficacy were figured out.Results There were 265 benign and 235 malignant lesions.In malignant lesions,THC of ≥2 cm lesion group was higher than that of ＜2 cm lesion group(P =0.000).In benign lesions,there was no statistical difference between ≥2 cm group and ＜2 cm group (P =0.13).As for ＜2 cm breast lesions,when a THC threshold value of 146.9 μmol/L and 102.2 μmol/L were used,the sensitivity,specificity,positive predictive value,negative predictive value and accuracy were 74.2％,70.0％,71.7％,62.9％,79.9％ and 86.7％,44.4％,61.6％,51.6％,83％,respectively.As for ≥2 cm breast lesions,when a THC threshold value of 210.4 μmol/L were used,the sensitivity,specificity,positive predictive value,negative predictive value and accuracy were 74.0％,86.7％,79.1％,89.2％,69.2％.Conclusions THC of breast cancer increased with the increasing size of lesions.The different diagnostic threshold value should be used according to different size lesions so as to enhance sensitivity,specificity and accuracy.
