CAJ | 학술논문

目的制备一种载超顺磁性氧化铁和化疗药物阿霉素的多功能高分子微泡(MPMBs),探讨其体外超声和磁共振显像效果.方法采用双乳化法和冷冻干燥法制备MPMBs和普通高分子微泡(PMBs),检测前者的一般性质及其包封率和载药量,观察其体外释药特性以及超声和磁共振的显像效果.结果 MPMBs形态规则,粒径分布较均匀,包封率为(60.20±2.69)％,载药量为(6.02±0.27)％；体外释药实验证明超声能促进MPMBs中阿霉素的释放；体外超声显影实验显示MPMBs较PMBs显影效果好,体外磁共振显影实验证实MPMBs具备增强磁共振显像的功能.结论成功制备出的MPMBs是一种具备治疗功能以及超声、磁共振双模式显影效果的多功能造影剂.
목적 제비일충재초순자성양화철화화료약물아매소적다공능고분자미포(MPMBs),탐토기체외초성화자공진현상효과.방법 채용쌍유화법화냉동간조법제비MPMBs화보통고분자미포(PMBs),검측전자적일반성질급기포봉솔화재약량,관찰기체외석약특성이급초성화자공진적현상효과.결과 MPMBs형태규칙,립경분포교균균,포봉솔위(60.20±2.69)％,재약량위(6.02±0.27)％；체외석약실험증명초성능촉진MPMBs중아매소적석방；체외초성현영실험현시MPMBs교PMBs현영효과호,체외자공진현영실험증실MPMBs구비증강자공진현상적공능.결론 성공제비출적MPMBs시일충구비치료공능이급초성、자공진쌍모식현영효과적다공능조영제.
Objective To prepare a kind of superparamagnetic iron oxide (SPIO) and doxorubicin loaded multifunctional polymer microbubbles (MPMBs),and to explore its potential application as an ultrasound(US)/magnetic resonance (MR) imaging contrast agent in vitro.Methods The MPMBs and normal polymer microbubbles (PMBs) were made by double emulsion and freeze-drying methods.The physical property,drug encapsulation efficiency and the drug-loading efficiency of MPMBs were determined,and the release property and US/MR imaging enhancement of MPMBs were observed.Results The MPMBs had a regular shape and narrow size distribution.The drug encapsulation efficiency was (60.20±2.69) ％,and the drug-loading efficiency was (6.02 ± 0.27) ％.The in vitro release experiment showed that ultrasound can promote the release of doxorubicin in MPMBs.US imaging in vitro showed that the enhancement of MPMBs was better than PMBs,and MR imaging in vitro conformed that MPMBs could well enhance MR imaging.Conclusions The MPMBs is a multifunctional contrast agent with the treatment function as well as US/MR dual-mode imaging enhancement effect.