CAJ | 학술논문

目的初步探讨声触诊组织量化(VTQ)技术在肝局灶性小病变定性诊断中的应用价值.方法对77例89个肝局灶性小病变(病灶最大径≤3 cm)进行VTQ检测,测量病灶及其周围背景肝组织剪切波速度(SWV),并与40例健康志愿者肝右叶SWV进行对比.分析不同病理类型病灶SWV的差异,并与背景肝组织、正常肝组织进行比较,采用ROC曲线找出SWV预测肝恶性局灶性小病变的最佳截点.结果恶性病灶SWV值明显高于良性病灶,两者差异有统计学意义[(2.56±0.67)m/s对(1.70±0.55)m/s,P=0.000],转移性肝癌组中肺癌及乳腺癌肝转移者SWV值高于胃肠道肿瘤肝转移者(P=0.000),良、恶性病灶的硬度均大于正常肝组织(P＜0.01).以SWV 1.93m/s为截点诊断肝恶性病变的灵敏性、特异性、准确性、阳性预测值、阴性预测值分别为82.0％、84.6％、83.15％、87.23％、78.57％.结论 VTQ技术有助于肝局灶性小病变的定性诊断.
목적 초보탐토성촉진조직양화(VTQ)기술재간국조성소병변정성진단중적응용개치.방법 대77례89개간국조성소병변(병조최대경≤3 cm)진행VTQ검측,측량병조급기주위배경간조직전절파속도(SWV),병여40례건강지원자간우협SWV진행대비.분석불동병리류형병조SWV적차이,병여배경간조직、정상간조직진행비교,채용ROC곡선조출SWV예측간악성국조성소병변적최가절점.결과 악성병조SWV치명현고우량성병조,량자차이유통계학의의[(2.56±0.67)m/s대(1.70±0.55)m/s,P=0.000],전이성간암조중폐암급유선암간전이자SWV치고우위장도종류간전이자(P=0.000),량、악성병조적경도균대우정상간조직(P＜0.01).이SWV 1.93m/s위절점진단간악성병변적령민성、특이성、준학성、양성예측치、음성예측치분별위82.0％、84.6％、83.15％、87.23％、78.57％.결론 VTQ기술유조우간국조성소병변적정성진단.
Objective To evaluate the application value of virtual touch tissue quantification (VTQ)for evaluating small focal liver lesions.Methods Seventy-seven patients with 89 small focal liver lesions,whose largest diameter were less than or equal to 3 cm were evaluated with VTQ.The shcar wave velocity (SWV) of the tumor and background liver parenchyma were calculated,and their results were compared with those of 40 healthy subjects.Statistical analysis was performed on the SWV for the differentiation of normal liver,background liver parenchyma and lesions.The cut-off point for SWV was obtained by using ROC curve analysis which was used to predict malignancy lesions.Results The SWV of malignant lesions was significantly higher than that of benign ones [(2.56-± 0.67) m/s vs (1.70 ± 0.55) m/s,P =0.000].The SWV of metastatic liver carcinoma which came from lung cancer and breast cancer were higher than that of gastrointestinal tract cancer transfers (P =0.000).Based on 1.93 m/s as the cut-off point of SWV value,the sensitivity,specificity,accuracy,positive predictive value and negative predictive value for diagnosing malignancies were 82.0 ％,84.6％,83.15 ％,87.23 ％ and 78.57 ％ respectively.Conclusions VTQ technique can help the differential diagnosis of small focal liver lesions.