中华超声影像学杂志
中華超聲影像學雜誌
중화초성영상학잡지
CHINESE JOURNAL OF ULTRASONOGRAPHY
2013年
5期
406-409
,共4页
超声检查,多普勒,彩色%高血压,妊娠性%肾%血液动力学现象
超聲檢查,多普勒,綵色%高血壓,妊娠性%腎%血液動力學現象
초성검사,다보륵,채색%고혈압,임신성%신%혈액동역학현상
Ultrasonography,Doppler,color%Hypertension,pregnancy-induced%Kidney%Hemodynamic phenomena
目的 探讨妊娠高血压疾病(HDCP)患者内皮素-1(ET-1)和一氧化氮(NO)对肾动脉血流动力学的影响及肾血流动力学改变在妊娠高血压诊断中的应用价值.方法 妊娠高血压患者56例,其中妊娠期高血压组(GH)18例,轻度子痫前期组(轻度PE) 18例,重度子痫前期组(重度PE)20例；正常妊娠者20例为对照组.应用彩色多普勒超声测量肾叶间动脉收缩期峰值流速(PSV)、舒张末期流速(EDV)、阻力指数(RI)、搏动指数(PI)等指标,同时检测血清ET-1和NO浓度.结果 轻度及重度PE组EDV低于正常妊娠组,差异有统计学意义(P＜0.05).轻度及重度PE组RI、PI、S/D值均高于正常妊娠组,差异有统计学意义(P＜0.05).妊娠高血压疾病患者血清ET-1水平高于正常妊娠组,且随病情的加重ET-1水平升高,差异有统计学意义(P＜0.01)；妊娠高血压患者血清NO水平低于正常妊娠组,且随病情的加重NO水平降低,差异有统计学意义(P＜0.01).妊娠高血压疾病患者肾叶间动脉S/D、RI、PI与血清ET-1呈正相关(P＜0.05),与血清NO呈负相关(P＜0.01).结论 彩色多普勒超声测量的肾血流动力学参数是反映HDCP患者血流变化和肾脏损害的敏感指标,与反映血管内皮功能的细胞因子ET-1和NO有良好的相关性.
目的 探討妊娠高血壓疾病(HDCP)患者內皮素-1(ET-1)和一氧化氮(NO)對腎動脈血流動力學的影響及腎血流動力學改變在妊娠高血壓診斷中的應用價值.方法 妊娠高血壓患者56例,其中妊娠期高血壓組(GH)18例,輕度子癇前期組(輕度PE) 18例,重度子癇前期組(重度PE)20例；正常妊娠者20例為對照組.應用綵色多普勒超聲測量腎葉間動脈收縮期峰值流速(PSV)、舒張末期流速(EDV)、阻力指數(RI)、搏動指數(PI)等指標,同時檢測血清ET-1和NO濃度.結果 輕度及重度PE組EDV低于正常妊娠組,差異有統計學意義(P＜0.05).輕度及重度PE組RI、PI、S/D值均高于正常妊娠組,差異有統計學意義(P＜0.05).妊娠高血壓疾病患者血清ET-1水平高于正常妊娠組,且隨病情的加重ET-1水平升高,差異有統計學意義(P＜0.01)；妊娠高血壓患者血清NO水平低于正常妊娠組,且隨病情的加重NO水平降低,差異有統計學意義(P＜0.01).妊娠高血壓疾病患者腎葉間動脈S/D、RI、PI與血清ET-1呈正相關(P＜0.05),與血清NO呈負相關(P＜0.01).結論 綵色多普勒超聲測量的腎血流動力學參數是反映HDCP患者血流變化和腎髒損害的敏感指標,與反映血管內皮功能的細胞因子ET-1和NO有良好的相關性.
목적 탐토임신고혈압질병(HDCP)환자내피소-1(ET-1)화일양화담(NO)대신동맥혈류동역학적영향급신혈류동역학개변재임신고혈압진단중적응용개치.방법 임신고혈압환자56례,기중임신기고혈압조(GH)18례,경도자간전기조(경도PE) 18례,중도자간전기조(중도PE)20례；정상임신자20례위대조조.응용채색다보륵초성측량신협간동맥수축기봉치류속(PSV)、서장말기류속(EDV)、조력지수(RI)、박동지수(PI)등지표,동시검측혈청ET-1화NO농도.결과 경도급중도PE조EDV저우정상임신조,차이유통계학의의(P＜0.05).경도급중도PE조RI、PI、S/D치균고우정상임신조,차이유통계학의의(P＜0.05).임신고혈압질병환자혈청ET-1수평고우정상임신조,차수병정적가중ET-1수평승고,차이유통계학의의(P＜0.01)；임신고혈압환자혈청NO수평저우정상임신조,차수병정적가중NO수평강저,차이유통계학의의(P＜0.01).임신고혈압질병환자신협간동맥S/D、RI、PI여혈청ET-1정정상관(P＜0.05),여혈청NO정부상관(P＜0.01).결론 채색다보륵초성측량적신혈류동역학삼수시반영HDCP환자혈류변화화신장손해적민감지표,여반영혈관내피공능적세포인자ET-1화NO유량호적상관성.
Objective To investigate if the endothelin-1 (ET-1),nitric oxide(NO) can affect renal artery blood flow and explore the clinical value of ultrasonography in hypertensive disorder complication pregnancy.Methods 18 patients of gestational hypertension,18 patients of gently preeclampsia,20 patients of severe preeclampsia and 20 normal pregnancy women were chosen in random.Color Doppler ultrasonography was used to detect the peak systolic velocity (PSV),end diastolic velocity (EDV),resistive index (RI),pulsatility index (PI) of renal interlobar artery.The levels of serum ET-1 and NO were measured by enzyme-linked immunosorbent assay (ELISA) and nitric acid recovery respectively.Results The level of EDV in preeclampsia patients were significant lower than the control group (P ＜0.05).The levels of RI,PI,S/D in preeclampsia patients were significant higher than the control group (P ＜0.05).The level of ET-1 in study group was higher than control group (P ＜0.01).The level of NO in study group was lower than control group (P ＜0.01).There was positive correlation between the RI,PI,S/D of renal interlobar artery and the level of serum ET-1.There was inverse correlation between the RI,PI,S/D of renal interlobar artery and the level of serum NO.Conclusions Endothelial dysfunction can cause unbalance of renal vessel systolic-diastolic function.The level of renal artery blood flow parameters can reflect the state of vessel function and have clinical value in hypertensive disorder complication pregnancy.
