CAJ | 학술논문

目的探讨脂肪肝与正常肝内VX2移植瘤常规超声特征,对比分析两种肝背景及其内VX2移植瘤血流灌注特征.方法建立兔脂肪肝与正常肝内VX2移植瘤并进行常规超声及超声造影检查,应用QontraXt超声造影定量分析软件进行定量分析.结果成功建立兔脂肪肝内VX2移植瘤结节20个,正常肝内VX2移植瘤结节23个.两组肝内等、低回声肿瘤结节发生率差异无统计学意义(P＞0.05),脂肪肝内高回声VX2移植瘤结节较正常肝内少(P=0.008).脂肪肝背景造影始增时间晚于正常肝(P＜0.05),峰值强度低于正常肝(P＜0.05).脂肪肝内VX2移植瘤造影始增时间、峰值强度、曲线尖度、曲线下面积与正常肝内VX2移植瘤比较,差异均无统计学意义(均P＞0.05).结论脂肪肝内VX2移植瘤常规超声回声与正常肝内有所差异；脂肪肝背景造影剂灌注效应低于正常肝.超声造影定量参数更能客观准确地反映VX2移植瘤及脂肪肝的血流动力学特征.
목적 탐토지방간여정상간내VX2이식류상규초성특정,대비분석량충간배경급기내VX2이식류혈류관주특정.방법 건립토지방간여정상간내VX2이식류병진행상규초성급초성조영검사,응용QontraXt초성조영정량분석연건진행정량분석.결과 성공건립토지방간내VX2이식류결절20개,정상간내VX2이식류결절23개.량조간내등、저회성종류결절발생솔차이무통계학의의(P＞0.05),지방간내고회성VX2이식류결절교정상간내소(P=0.008).지방간배경조영시증시간만우정상간(P＜0.05),봉치강도저우정상간(P＜0.05).지방간내VX2이식류조영시증시간、봉치강도、곡선첨도、곡선하면적여정상간내VX2이식류비교,차이균무통계학의의(균P＞0.05).결론 지방간내VX2이식류상규초성회성여정상간내유소차이；지방간배경조영제관주효응저우정상간.초성조영정량삼수경능객관준학지반영VX2이식류급지방간적혈류동역학특정.
Objective To investigate the conventional ultrasound characteristics of VX2 tumors in fatty liver and normal liver of rabbits,furthermore,to analysis the blood flow characteristics of them with contrast-enhanced ultrasound (CEUS).Methods Rabbit model of fatty liver and normal liver with implanted VX2 tumors were established,and examined using conventional and CEUS.QontraXt quantitative software of CEUS was used.Results The fatty liver models with 20 VX2 tumors and normal liver models with 23 VX2 tumors were successfully developed in rabbits.In conventional ultrasonography,hyperechoic VX2 tumor lesions in fatty liver were far less than them in normal liver (P =0.008).No significant difference was found in iso-echoic and hypoechoic VX2 tumor lesions between two groups (P ＞ 0.05).Compared with normal liver parenchyma,arrival time of fatty liver parenchyma was later,peak intensity was lower (P ＜0.05).There was no significant difference in arrival time,peak intensity,sharpness,area under curve between the VX2 tumors of normal liver and fatty liver (P ＞ 0.05).Conclusions There is a significant difference characteristic in conventional ultrasonography between VX2 tumors in fatty liver and normal liver.Fatty liver blood perfusion effects are lower than normal liver in CEUS.Quantitative parameters of CEUS are more objective and accurate for hemodynamic of VX2 tumors and fatty liver.