CAJ | 학술논문

目的探讨通过彩色多普勒超声评价移植肝内血流动力学参数变化预测移植肝急性排异的可行性.方法 68例移植肝患者,其中无明显排异活动者[排异活动指数(RAI)值＜3分]24例,轻度急性排异者(RAI值4～5分)23例,中重度急性排异者(RAI值6～9分)21例.所有患者均有穿刺病理学检查结果,穿刺前24 h内及治疗1周后均进行彩色多普勒超声检查.结果移植肝中重度急性排异时,肝内门静脉峰值流速值(31.4± 14.1)cm/s,明显低于移植肝无排异组(45.1±17.7) cm/s,差别有统计学意义(P＜0.05).治疗1周后随访,移植肝中重度排异组门静脉峰值流速上升,达(46.7±21.8) cm/s(P＜0.05).结论移植肝内门静脉峰值流速下降对预测移植肝急性排异发生有一定价值.
목적 탐토통과채색다보륵초성평개이식간내혈류동역학삼수변화예측이식간급성배이적가행성.방법 68례이식간환자,기중무명현배이활동자[배이활동지수(RAI)치＜3분]24례,경도급성배이자(RAI치4～5분)23례,중중도급성배이자(RAI치6～9분)21례.소유환자균유천자병이학검사결과,천자전24 h내급치료1주후균진행채색다보륵초성검사.결과 이식간중중도급성배이시,간내문정맥봉치류속치(31.4± 14.1)cm/s,명현저우이식간무배이조(45.1±17.7) cm/s,차별유통계학의의(P＜0.05).치료1주후수방,이식간중중도배이조문정맥봉치류속상승,체(46.7±21.8) cm/s(P＜0.05).결론 이식간내문정맥봉치류속하강대예측이식간급성배이발생유일정개치.
Objective To investigate the viability of analysis of hemodynamic changes with color Doppler flow imaging in the prediction of acute rejection in transplanted liver.Methods Sixty-eight patients enrolled in the study were categorized into three groups:transplanted liver without acute rejection [rejection activity index(RAI) 0-3,n =24],transplanted liver with mild acute rejection (RAI 4-5,n =23),transplanted liver with moderate and severe acute rejection (RAI 6-9,n =21).All the patients were confirmed by pathology.The color Doppler flow imaging were performed in all the patients within 24 hours and 1 week after biopsy.Results In transplanted liver with moderate and severe acute rejection,the peak systolic velocity of portal vein (PV-PSV) was (31.4 ± 14.1)cm/s,significantly lower than that in transplanted liver without acute rejection,which was (45.1 ± 17.7)cm/s (P ＜0.05).A week later after steroid therapy,the PV-PSV in transplanted liver with moderate and severe rejection was increased to (46.7 ± 21.8)cm/s(P ＜0.05).Patients with acute rejection were associated with the decrease of the PVPSV (P ＜0.05).Conclusions The decrease of PV-PSV may have some clinical value in evaluation the acute rejection in transplanted liver.