CAJ | 학술논문

目的应用实时超声造影成像技术结合时间-强度曲线观察兔脂肪肝及正常肝背景下肝炎性假瘤的血流灌注特征.方法脂肪肝及正常肝背景下炎性假瘤实验兔各10只,共种植39个结节,经耳缘静脉团注超声造影剂SonoVue后,应用CnTI低机械指数实时超声造影成像技术结合QontraXt定量分析软件,观察三期肝炎性假瘤结节及周围肝组织的动态增强过程.结果 ①肝炎性假瘤超声造影可表现为4种形式:1个为无明显增强型(Ⅰ型),19个为等增强型(Ⅱ型),6个为低增强型(Ⅲ型),13个为快速廓清型(Ⅳ型);②与正常肝背景相比,脂肪肝背景造影到达时间晚,峰值强度低,差异均有统计学意义(P＜0.05);③两组炎性假瘤与其周围肝实质相比,到达时间晚,峰值强度低,曲线尖度高,差异均有统计学意义(P＜0.05);④脂肪肝背景下的炎性假瘤与正常肝背景下的炎性假瘤相比,各超声造影参数差异均无统计学意义(P＞0.05).结论肝炎性假瘤因不同的病理成分,超声造影可表现为多种灌注形式,超声造影定量分析可更精确反映肝炎性假瘤及不同肝背景的血流灌注情况.
목적 응용실시초성조영성상기술결합시간-강도곡선관찰토지방간급정상간배경하간염성가류적혈류관주특정.방법 지방간급정상간배경하염성가류실험토각10지,공충식39개결절,경이연정맥단주초성조영제SonoVue후,응용CnTI저궤계지수실시초성조영성상기술결합QontraXt정량분석연건,관찰삼기간염성가류결절급주위간조직적동태증강과정.결과 ①간염성가류초성조영가표현위4충형식:1개위무명현증강형(Ⅰ형),19개위등증강형(Ⅱ형),6개위저증강형(Ⅲ형),13개위쾌속곽청형(Ⅳ형);②여정상간배경상비,지방간배경조영도체시간만,봉치강도저,차이균유통계학의의(P＜0.05);③량조염성가류여기주위간실질상비,도체시간만,봉치강도저,곡선첨도고,차이균유통계학의의(P＜0.05);④지방간배경하적염성가류여정상간배경하적염성가류상비,각초성조영삼수차이균무통계학의의(P＞0.05).결론 간염성가류인불동적병리성분,초성조영가표현위다충관주형식,초성조영정량분석가경정학반영간염성가류급불동간배경적혈류관주정황.
Objective To analyze hepatic inflammatory pseudoneoplasm with fatty liver and normal liver perfusion blood characteristics and quantitative parameters using real-time contrast-enhanced ultrasound (CEUS) and time intensity curve.Methods Twenty rabbits (including ten with fatty liver and ten with normal liver) with thirty-nine inflammatory pseudoneoplasm of the liver (IPL) were studied by low mechanical index CEUS with bolus injection of SonoVue via peripheral auricular vein and QontraXt quantitative analysis software.IPL contrast-enhanced ultrasound blood perfusion characteristics with two different liver background were analyzed.Results ①According to the different pathological elements,IPL showed four kinds of CEUS types:one lesion showed absent contrast enhancement pattern (type Ⅰ),nineteen lesions showed iso-enhancement pattern (type Ⅱ),six lesions showed hypo-enhancement pattern (type Ⅲ),thirteen lesions showed fast-in and fast-out pattern (type Ⅳ).②Compared with normal liver,arrival time of fatty liver was later and its peak intensity was lower.②Compared with peripheral parenchyma,arrival time of IPL was later,peak intensity was lower and its sharpness was sharper (P ＜0.05).④Between IPL lesions with two different liver background,there was no significant difference about parameters of the time-intensity curve (P ＞0.05).Conclusions Due to different pathological elements,IPL lesions have multiform perfusion patterns in CEUS.CEUS and time intensity curve could provide enough perfusion information for IPL and liver parenchyma more accurately.