中华超声影像学杂志
中華超聲影像學雜誌
중화초성영상학잡지
CHINESE JOURNAL OF ULTRASONOGRAPHY
2013年
10期
893-896
,共4页
徐宇雪%贾春梅%陈武%李淳%郝艳红%陈敏%郭小海
徐宇雪%賈春梅%陳武%李淳%郝豔紅%陳敏%郭小海
서우설%가춘매%진무%리순%학염홍%진민%곽소해
超声检查%肝硬化,实验性%弹性成像
超聲檢查%肝硬化,實驗性%彈性成像
초성검사%간경화,실험성%탄성성상
Ultrasonography%Liver cirrhosis,experimental%Elastography
目的 探讨实时组织弹性成像(RTE)弥散定量分析技术评估肝纤维化程度的价值.方法 应用6％硫代乙酰胺对51只大鼠制作肝纤维化模型,注射同等量生理盐水的9只大鼠作为对照组.于造模的4周、8周、12周分别从造模组中随机取14只,从对照组中随机取3只行RTE检查,并行组织弥散定量分析,获取12个弹性定量参数,包括应变均值(MEAN)、标准偏差(SD)、蓝色区域％(％AREA)、复杂度(COMP)、峰度(KURT)、偏度(SKEW)、对比度(CONT)、均等性(ENT)、杂乱度(IDM)、一致性(ASM)、相关性(CORR)及肝弹性指数(LF index).随后处死大鼠,取其肝脏行肝纤维化病理分期,并将造模组分为S0、S1、S2、S3、S4组,将各组12个弹性定量参数进行对照研究.结果 49只大鼠造模成功,纳入分析的有42只.除COMP、KURT、CORR外,余9个弹性定量参数多组间比较差异均有统计学意义(P＜0.05),且与病理分期均存在相关性,其中MEAN、％AREA及LF index的相关系数较大(r=-0.831、0.882、0.866).分别以MEAN、％AREA及LF index绘制判断肝纤维化分期的ROC曲线,S≥S1、S≥S2、S≥S3、S=S4时曲线下面积分别为0.884、0.925、0.934、0.962 (MEAN),0.917、0.958、0.984、0.962(％ AREA),0.917、0.948、0.966、0.967(LF index).结论 RTE弥散定量分析技术作为一种无创性检查方法,能够定量评估肝纤维化分期.
目的 探討實時組織彈性成像(RTE)瀰散定量分析技術評估肝纖維化程度的價值.方法 應用6％硫代乙酰胺對51隻大鼠製作肝纖維化模型,註射同等量生理鹽水的9隻大鼠作為對照組.于造模的4週、8週、12週分彆從造模組中隨機取14隻,從對照組中隨機取3隻行RTE檢查,併行組織瀰散定量分析,穫取12箇彈性定量參數,包括應變均值(MEAN)、標準偏差(SD)、藍色區域％(％AREA)、複雜度(COMP)、峰度(KURT)、偏度(SKEW)、對比度(CONT)、均等性(ENT)、雜亂度(IDM)、一緻性(ASM)、相關性(CORR)及肝彈性指數(LF index).隨後處死大鼠,取其肝髒行肝纖維化病理分期,併將造模組分為S0、S1、S2、S3、S4組,將各組12箇彈性定量參數進行對照研究.結果 49隻大鼠造模成功,納入分析的有42隻.除COMP、KURT、CORR外,餘9箇彈性定量參數多組間比較差異均有統計學意義(P＜0.05),且與病理分期均存在相關性,其中MEAN、％AREA及LF index的相關繫數較大(r=-0.831、0.882、0.866).分彆以MEAN、％AREA及LF index繪製判斷肝纖維化分期的ROC麯線,S≥S1、S≥S2、S≥S3、S=S4時麯線下麵積分彆為0.884、0.925、0.934、0.962 (MEAN),0.917、0.958、0.984、0.962(％ AREA),0.917、0.948、0.966、0.967(LF index).結論 RTE瀰散定量分析技術作為一種無創性檢查方法,能夠定量評估肝纖維化分期.
목적 탐토실시조직탄성성상(RTE)미산정량분석기술평고간섬유화정도적개치.방법 응용6％류대을선알대51지대서제작간섬유화모형,주사동등량생리염수적9지대서작위대조조.우조모적4주、8주、12주분별종조모조중수궤취14지,종대조조중수궤취3지행RTE검사,병행조직미산정량분석,획취12개탄성정량삼수,포괄응변균치(MEAN)、표준편차(SD)、람색구역％(％AREA)、복잡도(COMP)、봉도(KURT)、편도(SKEW)、대비도(CONT)、균등성(ENT)、잡란도(IDM)、일치성(ASM)、상관성(CORR)급간탄성지수(LF index).수후처사대서,취기간장행간섬유화병리분기,병장조모조분위S0、S1、S2、S3、S4조,장각조12개탄성정량삼수진행대조연구.결과 49지대서조모성공,납입분석적유42지.제COMP、KURT、CORR외,여9개탄성정량삼수다조간비교차이균유통계학의의(P＜0.05),차여병리분기균존재상관성,기중MEAN、％AREA급LF index적상관계수교대(r=-0.831、0.882、0.866).분별이MEAN、％AREA급LF index회제판단간섬유화분기적ROC곡선,S≥S1、S≥S2、S≥S3、S=S4시곡선하면적분별위0.884、0.925、0.934、0.962 (MEAN),0.917、0.958、0.984、0.962(％ AREA),0.917、0.948、0.966、0.967(LF index).결론 RTE미산정량분석기술작위일충무창성검사방법,능구정량평고간섬유화분기.
Objective To explore the value of real-time tissue elastography (RTE) with tissue dispersion quantitative analysis technique for assessment of liver fibrosis stage.Methods 51 rats were injected 6％ thioacetamide to induce liver fibrosis model,and 9 rats were injected saline as control group.In modeling 4 weeks,8 weeks,12 weeks respectively,14 rats in group of liver fibrosis model and 3 rats in control group were randomly selected to RTE.All the rats underwent tissue dispersion quantitative analysis,to obtain 12 quantitative parameters of elasticity,which included average relative strain value (MEAN),standard deviation of relative strain value (SD),area ratio of low-strain region (％ AREA),complexity (COMP),kurtosis (KURT),skewness (SKEW),contrast (CONT),entropy (ENT),inverse difference moment (IDM),angular second moment (ASM),correlation (CORR) and liver elasticity index (LF index).Subsequently,rats were sacrificed and their livers were taken for pathology analysis.Liver fibrosis model group was divided into S0,S1,S2,S3,S4 group.The 12 quantitative parameters of elasticity were compared with each group.Results 49 rats were successfully modeled,and 42 rats were analyzed.Except COMP,KURT,CORR,the other quantitative parameters had statistically differences (P ＜ 0.05).The other 9 parameters were correlated with liver fibrosis stage.Among these parameters,MEAN,％ AREA and LF index had higher related coefficient(r =-0.831,0.882,0.866).The ROC curve was made by MEAN,LF index and ％AREA to estimate the fibrosis stage,when S≥S1,S≥S2,S≥S3,S =S4,the areas under the ROCcurve were 0.884,0.925,0.934,0.962 (MEAN);0.917,0.958,0.984,0.962 (％AREA);0.917,0.948,0.966,0.967 (LF index),respectively.Conclusions As a non-invasive examination,RTE dispersion quantitative analysis technology can be used to quantitatively assess liver fibrosis.
