中华超声影像学杂志
中華超聲影像學雜誌
중화초성영상학잡지
CHINESE JOURNAL OF ULTRASONOGRAPHY
2014年
1期
24-26
,共3页
朱好辉%袁建军%王一洒%高帆%王晓%魏常华%陈纪昀%樊晓惠
硃好輝%袁建軍%王一灑%高帆%王曉%魏常華%陳紀昀%樊曉惠
주호휘%원건군%왕일쇄%고범%왕효%위상화%진기윤%번효혜
超声检查%颈动脉%弹性%获得性免疫缺陷综合征%抗逆转录病毒治疗,高效
超聲檢查%頸動脈%彈性%穫得性免疫缺陷綜閤徵%抗逆轉錄病毒治療,高效
초성검사%경동맥%탄성%획득성면역결함종합정%항역전록병독치료,고효
Ultrasonography%Carotid artery%Elasticity%Acquired immunodeficiency syndrome%Antiretroviral therapy,highly active
目的 探讨我国目前艾滋病(acquired immune deficiency syndrome,AIDS)患者采用的一线高效抗逆转录病毒疗法(highly active antiretroviral therapy,HAART)治疗方案对AIDS患者颈动脉弹性的影响.方法 选取AIDS患者100例,非治疗组、HAART治疗组患者各50例,健康志愿者50例为对照组,行右侧颈动脉内-中膜厚度(IMT)测量和动脉弹性测量.结果 对照组、AIDS治疗组和非治疗组三组间IMT比较差异无统计学意义(P＞0.05);与对照组比较,AIDS治疗组和非治疗组颈动脉顺应性(CC)降低,僵硬度(β)、脉搏波传导速度(PWV)升高,差异具有统计学意义(P＜0.05);AIDS治疗组和非治疗组间IMT、CC、β、PWV差异无统计学意义(P＞0.05).结论 AIDS患者在未出现颈动脉IMT增厚的早期阶段,其弹性功能已减低.目前国内AIDS治疗采用的一线HAART治疗方案,在用药依从性好(80％以上)、无严重其他系统并发症的轻症AIDS患者中较长期应用以来,未见对其动脉弹性功能造成明显不良影响.
目的 探討我國目前艾滋病(acquired immune deficiency syndrome,AIDS)患者採用的一線高效抗逆轉錄病毒療法(highly active antiretroviral therapy,HAART)治療方案對AIDS患者頸動脈彈性的影響.方法 選取AIDS患者100例,非治療組、HAART治療組患者各50例,健康誌願者50例為對照組,行右側頸動脈內-中膜厚度(IMT)測量和動脈彈性測量.結果 對照組、AIDS治療組和非治療組三組間IMT比較差異無統計學意義(P＞0.05);與對照組比較,AIDS治療組和非治療組頸動脈順應性(CC)降低,僵硬度(β)、脈搏波傳導速度(PWV)升高,差異具有統計學意義(P＜0.05);AIDS治療組和非治療組間IMT、CC、β、PWV差異無統計學意義(P＞0.05).結論 AIDS患者在未齣現頸動脈IMT增厚的早期階段,其彈性功能已減低.目前國內AIDS治療採用的一線HAART治療方案,在用藥依從性好(80％以上)、無嚴重其他繫統併髮癥的輕癥AIDS患者中較長期應用以來,未見對其動脈彈性功能造成明顯不良影響.
목적 탐토아국목전애자병(acquired immune deficiency syndrome,AIDS)환자채용적일선고효항역전록병독요법(highly active antiretroviral therapy,HAART)치료방안대AIDS환자경동맥탄성적영향.방법 선취AIDS환자100례,비치료조、HAART치료조환자각50례,건강지원자50례위대조조,행우측경동맥내-중막후도(IMT)측량화동맥탄성측량.결과 대조조、AIDS치료조화비치료조삼조간IMT비교차이무통계학의의(P＞0.05);여대조조비교,AIDS치료조화비치료조경동맥순응성(CC)강저,강경도(β)、맥박파전도속도(PWV)승고,차이구유통계학의의(P＜0.05);AIDS치료조화비치료조간IMT、CC、β、PWV차이무통계학의의(P＞0.05).결론 AIDS환자재미출현경동맥IMT증후적조기계단,기탄성공능이감저.목전국내AIDS치료채용적일선HAART치료방안,재용약의종성호(80％이상)、무엄중기타계통병발증적경증AIDS환자중교장기응용이래,미견대기동맥탄성공능조성명현불량영향.
Objective To evaluate the effect of highly active antiretroviral therapy(HAART) on carotid artery stiffness in acquired immune deficiency syndrome (AIDS) patients.Methods 100 AIDS patients were enrolled in this study,and were divided into un-therapy group(n =50) and HAART group (n =50),50 cases healthy people as control group.Carotid artery QIMT and QAS was examined and the intima-media thickness(IMT) and stiffness parameters were obtained.Results There was no statistically significance of IMT in three groups(P ＞0.05).Comprare to the control group,compliance coefficent(CC)of un-therapy group and HAART group were decreased,stiffness β and pulse wave velocity(PWV) were increased,and there were statistically differences(P ＜0.05).But between un-therapy group and HAART group,there were no statistically differences of stiffness parameters(P ＞0.05).Conclusions The carotid artery stiffness had reduced before IMT thicken in AIDS patients.There was no association between firstline HAART and carotid artery stiffness in mild AIDS patients.
