CAJ | 학술논문

目的应用超声心动图评价非诺贝特对肥胖大鼠心肌重构的作用.方法高脂饮食喂养建立20只肥胖SD大鼠模型,随机分为肥胖组(OB组,10只)和非诺贝特组(F组,10只),同周龄SD大鼠10只作为正常对照组.F组以非诺贝特60 mg· kg-1.d-1灌胃8周,其余组予以等量生理盐水灌胃.分别于用药前后进行超声心动图检查,实验末处死动物进行组织学检查.结果实验末,与对照组相比,OB组体质量、室壁厚度、室间隔厚度、左室质量显著增加(P ＜0.叭),E/A值显著降低(P＜0.01),而且组织学检测显示心肌结构排列紊乱,心肌间质胶原纤维沉积;F组与OB组相比以上指标均有明显改善,差异有统计学意义(P＜0.01).超声所计算的左室质量与实体标本测量值具有较高的相关性(r =0.98.P＜0.01).结论非诺贝特具有改善SD肥胖大鼠心肌重构的作用,超声心动图能较全面地评价此作用.
목적 응용초성심동도평개비낙패특대비반대서심기중구적작용.방법 고지음식위양건립20지비반SD대서모형,수궤분위비반조(OB조,10지)화비낙패특조(F조,10지),동주령SD대서10지작위정상대조조.F조이비낙패특60 mg· kg-1.d-1관위8주,기여조여이등량생리염수관위.분별우용약전후진행초성심동도검사,실험말처사동물진행조직학검사.결과 실험말,여대조조상비,OB조체질량、실벽후도、실간격후도、좌실질량현저증가(P ＜0.팔),E/A치현저강저(P＜0.01),이차조직학검측현시심기결구배렬문란,심기간질효원섬유침적;F조여OB조상비이상지표균유명현개선,차이유통계학의의(P＜0.01).초성소계산적좌실질량여실체표본측량치구유교고적상관성(r =0.98.P＜0.01).결론 비낙패특구유개선SD비반대서심기중구적작용,초성심동도능교전면지평개차작용.
Objective To assess the effects of fenofibrate on myocardial remodeling in obese rats by echocardiography.Methods Twenty-six SD rats were fed with high fat chow to establish twenty obese rats models,which were randomly divided into two groups:obesity group (OB group,n =10) and fenofibrate group(F group,n =10).The same week-old SD rats group (n =10) was also randomly selected as normal control group.F group was given fenofibrate 60 mg · kg-1 · d-1 for 8 weeks,the other groups were given normal saline.Echocardiographic scan was performed in each group at the beginning and ending of the experiment.Twenty-four weeks later,all rats were executed and the cardiac muscle was used to histological inspect.Results After the experiment,compared with the control group,the body weight,the ventricular thickness,interventricular septal thickness and the left ventricular mass in OB group were significantly increased than those of control group(P ＜0.01),the E/A ratio was significantly decreased(P ＜0.01).Histological detection showed that myocardial structure was disordered,and that interstitial collagen was deposited in the myocardium.Compared with OB group,the parameters all above in F group were significantly improved (P ＜0.01).Left ventricular mass from echocardiography correlated well with the results from pathologic specimen (r =0.98,P ＜0.01).Conclusions Fenofibrate has beneficial effects on preventing myocardial remodeling.By general echocardiography,the effects can be assessed comprehensively and accurately.