中华超声影像学杂志
中華超聲影像學雜誌
중화초성영상학잡지
CHINESE JOURNAL OF ULTRASONOGRAPHY
2014年
4期
316-319
,共4页
于宁%杨舜舜%费洁%王正滨%杨雪
于寧%楊舜舜%費潔%王正濱%楊雪
우저%양순순%비길%왕정빈%양설
弹性成像技术%糖尿病肾病%剪切波速度%骨形态发生蛋白质7
彈性成像技術%糖尿病腎病%剪切波速度%骨形態髮生蛋白質7
탄성성상기술%당뇨병신병%전절파속도%골형태발생단백질7
Elasticity imaging techiniques%Diabetic nephropathies%Shear wave velocity%Bone morphogenetic protein 7
目的 探讨骨形态发生蛋白-7 (BMP-7)与肾剪切波速度(SWV)在糖尿病肾病中的相关性.方法 将150例糖尿病患者根据尿白蛋白排泄率(UAER)分为3组:正常白蛋白尿(NA)组、微量白蛋白尿(MA)组、临床蛋白尿(CA)组;选择50例健康体检者作为对照组(NC).检测各组血BMP-7水平,并利用声触诊组织量化技术检测各组肾实质SWV,比较各组间的BMP-7水平及肾实质SWV.对糖尿病肾病各组的血BMP-7水平与SWV进行相关性分析.结果 血BMP-7水平:CA组＜MA组＜NA组(P＜0.05);SWV测值:CA组＞MA组＞NA组(P＜0.05).NC组与NA组血BMP-7水平及SWV测值差异均无统计学意义(P＞0.05).血BMP-7与肾实质SWV之间存在显著负相关(r=-0.612,P＜0.05).结论 血BMP-7水平会随糖尿病肾病的进展而减低,而肾实质SWV则随糖尿病肾病的进展而升高,并可间接反映血清BMP-7水平,二者在糖尿病肾病诊治中有重要的应用价值.
目的 探討骨形態髮生蛋白-7 (BMP-7)與腎剪切波速度(SWV)在糖尿病腎病中的相關性.方法 將150例糖尿病患者根據尿白蛋白排洩率(UAER)分為3組:正常白蛋白尿(NA)組、微量白蛋白尿(MA)組、臨床蛋白尿(CA)組;選擇50例健康體檢者作為對照組(NC).檢測各組血BMP-7水平,併利用聲觸診組織量化技術檢測各組腎實質SWV,比較各組間的BMP-7水平及腎實質SWV.對糖尿病腎病各組的血BMP-7水平與SWV進行相關性分析.結果 血BMP-7水平:CA組＜MA組＜NA組(P＜0.05);SWV測值:CA組＞MA組＞NA組(P＜0.05).NC組與NA組血BMP-7水平及SWV測值差異均無統計學意義(P＞0.05).血BMP-7與腎實質SWV之間存在顯著負相關(r=-0.612,P＜0.05).結論 血BMP-7水平會隨糖尿病腎病的進展而減低,而腎實質SWV則隨糖尿病腎病的進展而升高,併可間接反映血清BMP-7水平,二者在糖尿病腎病診治中有重要的應用價值.
목적 탐토골형태발생단백-7 (BMP-7)여신전절파속도(SWV)재당뇨병신병중적상관성.방법 장150례당뇨병환자근거뇨백단백배설솔(UAER)분위3조:정상백단백뇨(NA)조、미량백단백뇨(MA)조、림상단백뇨(CA)조;선택50례건강체검자작위대조조(NC).검측각조혈BMP-7수평,병이용성촉진조직양화기술검측각조신실질SWV,비교각조간적BMP-7수평급신실질SWV.대당뇨병신병각조적혈BMP-7수평여SWV진행상관성분석.결과 혈BMP-7수평:CA조＜MA조＜NA조(P＜0.05);SWV측치:CA조＞MA조＞NA조(P＜0.05).NC조여NA조혈BMP-7수평급SWV측치차이균무통계학의의(P＞0.05).혈BMP-7여신실질SWV지간존재현저부상관(r=-0.612,P＜0.05).결론 혈BMP-7수평회수당뇨병신병적진전이감저,이신실질SWV칙수당뇨병신병적진전이승고,병가간접반영혈청BMP-7수평,이자재당뇨병신병진치중유중요적응용개치.
Objective To investigate the value of bone morphogenetic protein-7 (BMP-7) and the kidney shear wave velocity (SWV) in the diagnosis and treatment of diabetic nephropathy.Methods 150 cases of patients with diabetic mellitus were divided into three groups according to 24h urinary albumin excretion (Ualb):normalbuminuria (NA) group,microalbuminuria (MA) group and clinical proteinuria (CA) group;50 healthy subjects were selected as the control group (NC).The levels of blood BMP-7 were detected and the virtual touch tissue quantification (VTQ) was used to detect renal SWV in four groups.Both the BMP-7 level and the renal parenchyma SWV were compared among four groups.Then correlation analysis was made between blood of BMP-7 level and renal SWV in diabetic nephropathy groups.Results Blood BMP-7 level:the lowest was CA group,the middle one was MA group,and the highest was NA group (P ＜0.05),the NC group and the NA group had no significant difference (P ＞0.05); SWV measured values:CA group was the highest,MA group was middle one and the NA group was the lowest (P ＜ 0.05),the difference between NC group and the NA group was not significant statistically (P ＞0.05).The blood levels of BMP-7 and renal SWV had a significant negative correlation (r =-0.612,P ＜0.05).Conclusions The blood BMP-7 levels downregulate with the progressing of diabetic nephropathy,but the renal SWV increases with the diabetic nephropathy deterioration,and may indirectly reflects blood BMP-7 levels.Both of them have important application values in the diagnosis or treatment of diabetic nephropathy.
