中华超声影像学杂志
中華超聲影像學雜誌
중화초성영상학잡지
CHINESE JOURNAL OF ULTRASONOGRAPHY
2014年
4期
345-348
,共4页
杨彬%付峰%周晓东%于铭%何光彬%贺建国%郑宏志
楊彬%付峰%週曉東%于銘%何光彬%賀建國%鄭宏誌
양빈%부봉%주효동%우명%하광빈%하건국%정굉지
超声处理%微气泡%激光凝固术%肝肿瘤
超聲處理%微氣泡%激光凝固術%肝腫瘤
초성처리%미기포%격광응고술%간종류
Sonication%Microbubbles%Laser coagulation%Liver neoplasms
目的 探讨超声微泡击破技术增强激光热消融的治疗效果.方法 将48只荷瘤兔随机分为单纯激光治疗组、假微泡击破+激光治疗组、微泡击破+激光治疗组、空白对照组,通过影像学、解剖学、病理学指标观察治疗前后的形态学变化,比较各组间的差异.结果 病理证实实验组激光热消融治疗对肿瘤组织均产生了凝固性坏死,常规超声显示实验组治疗前后及对照组肿瘤最大直径和面积差异均无统计学意义(P＞0.05),对照组无治疗后的改变.超声造影显示消融区造影剂充盈缺损的面积分别为:单纯激光治疗组(0.83±0.06)cm2,假微泡击破+激光治疗组(0.65±0.05) cm2,激光+微泡击破治疗组(2.40±0.16)cm2,空白对照组(0.01±0.01) cm2.微泡击破技术联合激光消融治疗肿瘤所产生的造影剂充盈缺损的面积各组之间差异有统计学意义(P＜0.05).结论 微泡击破联合激光消融明显扩大单针激光消融兔肝VX2肿瘤的面积,可增加治疗的效果.
目的 探討超聲微泡擊破技術增彊激光熱消融的治療效果.方法 將48隻荷瘤兔隨機分為單純激光治療組、假微泡擊破+激光治療組、微泡擊破+激光治療組、空白對照組,通過影像學、解剖學、病理學指標觀察治療前後的形態學變化,比較各組間的差異.結果 病理證實實驗組激光熱消融治療對腫瘤組織均產生瞭凝固性壞死,常規超聲顯示實驗組治療前後及對照組腫瘤最大直徑和麵積差異均無統計學意義(P＞0.05),對照組無治療後的改變.超聲造影顯示消融區造影劑充盈缺損的麵積分彆為:單純激光治療組(0.83±0.06)cm2,假微泡擊破+激光治療組(0.65±0.05) cm2,激光+微泡擊破治療組(2.40±0.16)cm2,空白對照組(0.01±0.01) cm2.微泡擊破技術聯閤激光消融治療腫瘤所產生的造影劑充盈缺損的麵積各組之間差異有統計學意義(P＜0.05).結論 微泡擊破聯閤激光消融明顯擴大單針激光消融兔肝VX2腫瘤的麵積,可增加治療的效果.
목적 탐토초성미포격파기술증강격광열소융적치료효과.방법 장48지하류토수궤분위단순격광치료조、가미포격파+격광치료조、미포격파+격광치료조、공백대조조,통과영상학、해부학、병이학지표관찰치료전후적형태학변화,비교각조간적차이.결과 병리증실실험조격광열소융치료대종류조직균산생료응고성배사,상규초성현시실험조치료전후급대조조종류최대직경화면적차이균무통계학의의(P＞0.05),대조조무치료후적개변.초성조영현시소융구조영제충영결손적면적분별위:단순격광치료조(0.83±0.06)cm2,가미포격파+격광치료조(0.65±0.05) cm2,격광+미포격파치료조(2.40±0.16)cm2,공백대조조(0.01±0.01) cm2.미포격파기술연합격광소융치료종류소산생적조영제충영결손적면적각조지간차이유통계학의의(P＜0.05).결론 미포격파연합격광소융명현확대단침격광소융토간VX2종류적면적,가증가치료적효과.
Objective To investigate the basis of ultrasound microbubble technology enhanced thermal ablation effect.Methods All 48 rabbits bearing hepatic tumors were averagely randomly divided into four groups:only laser group,sham,destruction + laser group,and blank group.The filling defect area changes of before and after treatment were observed and the differences between groups were compared.Results Pathology confirmed ablation of tumor tissue could produce coagulation necrosis for experiment group.The conventional ultrasound showed there was no significant variation in the maximum diameter and area in the pre and post treatment of experiment group and control group(P ＞0.05).There was no change for the control group.Ultrasound imaging showed an area of filling defect were:laser treatment alone group (0.83 ± 0.06) cm2,microbubbles false break combined with laser therapy group (0.65 ± 0.05) cm2,microbubbles break combined with laser therapy group (2.40 ± 0.16)cm2,blank control group (0.01 ± 0.01) cm2.The filling defect area of the treatment group,which was combined with ultrasound microbubble break technology and laser ablation was increased,there was significant variation in the each group (P ＜0.05).Conclusions Microbubble burst combined laser ablation could expand the single needle laser ablation area of rabbit VX2 liver tumor and increase the therapeutic effect.
