CAJ | 학술논문

目的运用时空关联成像(STIC)技术测量胎儿左室容积,初步探索胎儿的左心功能特点.方法采集20～28孕周单胎胎儿的心脏容积数据(85例心脏正常胎儿和10例α-地中海贫血胎儿),运用三种STIC技术(VOCAL,Inversion和SonoAVC)测算胎儿左心功能参数.用组内相关系数(ICC)评测三种STIC技术在重复测量结果之间的可靠性和可重复性,对心脏正常胎儿和α-地中海贫血胎儿的左室功能参数进行两样本t检验.结果三种技术测量左室容积的ICC均＞0.90.Bland-Altman散点图显示测量差异的95％可信区间(CI)在可允许范围.α-地中海贫血胎儿组左室收缩末期容积、每搏量、射血分数与正常胎儿组差异有统计学意义(P＜0.05).结论三种STIC技术均可准确测量α-地中海贫血胎儿的左室容积,有助于研究胎儿病理状态下的心功能特点.
목적 운용시공관련성상(STIC)기술측량태인좌실용적,초보탐색태인적좌심공능특점.방법 채집20～28잉주단태태인적심장용적수거(85례심장정상태인화10례α-지중해빈혈태인),운용삼충STIC기술(VOCAL,Inversion화SonoAVC)측산태인좌심공능삼수.용조내상관계수(ICC)평측삼충STIC기술재중복측량결과지간적가고성화가중복성,대심장정상태인화α-지중해빈혈태인적좌실공능삼수진행량양본t검험.결과 삼충기술측량좌실용적적ICC균＞0.90.Bland-Altman산점도현시측량차이적95％가신구간(CI)재가윤허범위.α-지중해빈혈태인조좌실수축말기용적、매박량、사혈분수여정상태인조차이유통계학의의(P＜0.05).결론 삼충STIC기술균가준학측량α-지중해빈혈태인적좌실용적,유조우연구태인병리상태하적심공능특점.
Objective To preliminary investigate fetal left heart function of fetuses in α-thalassemia using spatio-temporal image correlation (STIC).Methods 95 volumes from fetal hearts in singleton pregnancies at 20-28 weeks of gestation were collected.STIC datasets were frozen in end-systole and enddiastole.Ventricular volumes were measured using VOCAL,Inversion and SonoAVC.The stroke volume was calculated from these measurements.Results All data sets could be measured with all three techniques in this study.The intraclass correlation coefficients (ICCs) between techniques were all ＞ 0.90.The time necessary to measure the stroke volume was significantly shorter using SonoAVC than using VOCAL and Inversion.Bland-Altman plots showed no clinically significant mean percent differences between stroke volume measurements obtained from each ventricle using three techniques.The left ventricular end-systole volume(ESV),stroke volume(SV)and ejection fraction(EF)was significantly different than fetuses with normal heart (P ＜ 0.05).Conclusions This study shows the feasibility of measuring left ventricular volumes during either systole or diastole and thereby calculating stroke volumes with all three techniques.And there was a high degree of reliability for all three techniques,as shown by excellent ICCs.There was good accuracy of STIC techniques in measuring fetal left ventricular volumes with cardiomegaly.