中华超声影像学杂志
中華超聲影像學雜誌
중화초성영상학잡지
CHINESE JOURNAL OF ULTRASONOGRAPHY
2014年
5期
438-442
,共5页
超声检查%肿瘤辅助疗法%靶向治疗%紫杉酚%有机硅化合物
超聲檢查%腫瘤輔助療法%靶嚮治療%紫杉酚%有機硅化閤物
초성검사%종류보조요법%파향치료%자삼분%유궤규화합물
Ultrasonography%Neoadjuvant therapy%Targeted therapy%Paclitaxel%Organosilicon compounds
目的 研究超声介导的新型载药超声造影剂在辅助肿瘤化疗方面的应用.方法 “结构差异选择性刻蚀法”制备载紫杉醇(paclitaxel,PTX)有序介孔有机硅(hollow periodic mesoporous organosilicas,HPMOs);体外评估超声辐照辅助其释药的效果;细胞存活率(cell counting Kit-8,CCK-8)实验评估超声辐照PTX-HPMOs对肿瘤细胞的杀伤力.结果 ①PTX-HPMOs载药量为91 mg/g;②HPMOs显示出良好的超声造影显像效果,且在常规超声条件下即可造影成像;③每次超声辐照PTXHPMOs可以增加18％的PTX释放量;④超声辐照后,PTX-HPMOs抗肿瘤效力明显增强,肿瘤细胞存活率明显下降.结论 此新型载药超声造影剂在增强超声显像的同时可以辅助肿瘤化疗.
目的 研究超聲介導的新型載藥超聲造影劑在輔助腫瘤化療方麵的應用.方法 “結構差異選擇性刻蝕法”製備載紫杉醇(paclitaxel,PTX)有序介孔有機硅(hollow periodic mesoporous organosilicas,HPMOs);體外評估超聲輻照輔助其釋藥的效果;細胞存活率(cell counting Kit-8,CCK-8)實驗評估超聲輻照PTX-HPMOs對腫瘤細胞的殺傷力.結果 ①PTX-HPMOs載藥量為91 mg/g;②HPMOs顯示齣良好的超聲造影顯像效果,且在常規超聲條件下即可造影成像;③每次超聲輻照PTXHPMOs可以增加18％的PTX釋放量;④超聲輻照後,PTX-HPMOs抗腫瘤效力明顯增彊,腫瘤細胞存活率明顯下降.結論 此新型載藥超聲造影劑在增彊超聲顯像的同時可以輔助腫瘤化療.
목적 연구초성개도적신형재약초성조영제재보조종류화료방면적응용.방법 “결구차이선택성각식법”제비재자삼순(paclitaxel,PTX)유서개공유궤규(hollow periodic mesoporous organosilicas,HPMOs);체외평고초성복조보조기석약적효과;세포존활솔(cell counting Kit-8,CCK-8)실험평고초성복조PTX-HPMOs대종류세포적살상력.결과 ①PTX-HPMOs재약량위91 mg/g;②HPMOs현시출량호적초성조영현상효과,차재상규초성조건하즉가조영성상;③매차초성복조PTXHPMOs가이증가18％적PTX석방량;④초성복조후,PTX-HPMOs항종류효력명현증강,종류세포존활솔명현하강.결론 차신형재약초성조영제재증강초성현상적동시가이보조종류화료.
Objective To Study the application of ultrasound mediated drug-loading ultrasound contrast agents in auxiliary cancer chemotherapy.Methods Carrying paclitaxel (PTX) hollow periodic mesoporous organosilicas(HPMOs) were prepared by "Structural differences selective etching method".The drug release kinetics of ultrasound mediated in vitro were evaluated at different time points of ultrasound radiation to PTX-HPMOs.The cell survival were evaluated by CCK8 experiment.Results ① The drug loading of PTX-HPMOs was 91 mg/g.②The achieved HMONs showed the high stability and excellent contrast enhancement for ultrasound imaging both in vitro.HPMOs showed the same good effect of contrastenhanced ultrasound imaging as SonoVue.③Drug-loaded HMONs exhibit ultrasound-responsive drug release performance.The ultrasonic stimulation can increase the release of 18 ％ of PTX each time.④ After ultrasonic stimulation,PTX-HPMOs showed good antitumor effect in vitro.Conclusions The new type of drug loading ultrasound contrast agents show good ultrasonic imaging and can help the cancer chemotherapy at the same time.
