CAJ | 학술논문

目的探讨声触诊组织量化(virtual touch tissue quantification,VTQ)技术在肝良恶性病灶诊断中的应用价值.方法对172例肝实性局灶性病变患者共计192枚病灶行VTQ检测,获取病灶及其周围背景肝组织的剪切波速度(shear wave velocity,SWV)值,同时选取60例健康志愿者为对照组.分析不同病理类型病灶SWV的差异,并与背景肝组织、正常肝组织SWV进行比较,采用ROC曲线找出SWV预测肝恶性局灶性病变的最佳截点.结果肝恶性病灶的SWV值明显高于良性病灶,两者差异具有统计学意义[(2.83±0.91) m/s对(1.83±0.64)m/s,P=0.000];恶性病灶与正常肝组织、良性病灶与正常肝组织间SWV差异均有统计学意义(P＜0.01).以SWV=2.19 m/s为截点诊断肝恶性病灶的敏感性、特异性、准确性、阳性预测值、阴性预测值分别为82.5％、75.4％、77.03％、81.16％、78.9％.结论 VTQ技术对肝局灶性病变的良恶性鉴别提供了客观有用的信息,具有良好的临床应用价值.
목적 탐토성촉진조직양화(virtual touch tissue quantification,VTQ)기술재간량악성병조진단중적응용개치.방법 대172례간실성국조성병변환자공계192매병조행VTQ검측,획취병조급기주위배경간조직적전절파속도(shear wave velocity,SWV)치,동시선취60례건강지원자위대조조.분석불동병리류형병조SWV적차이,병여배경간조직、정상간조직SWV진행비교,채용ROC곡선조출SWV예측간악성국조성병변적최가절점.결과 간악성병조적SWV치명현고우량성병조,량자차이구유통계학의의[(2.83±0.91) m/s대(1.83±0.64)m/s,P=0.000];악성병조여정상간조직、량성병조여정상간조직간SWV차이균유통계학의의(P＜0.01).이SWV=2.19 m/s위절점진단간악성병조적민감성、특이성、준학성、양성예측치、음성예측치분별위82.5％、75.4％、77.03％、81.16％、78.9％.결론 VTQ기술대간국조성병변적량악성감별제공료객관유용적신식,구유량호적림상응용개치.
Objective To explore the clinical application value of virtual touch tissue quantification (VTQ) in the differential diagnosis of focal liver lesions.Methods 174 patients with 194 focal liver lesions and 60 healthy volunteers were enrolled in this study,shear wave velocity(SWV) of lesions,background liver parenchyma and healthy liver were evaluated with VTQ examination.Statistical analysis was performed on the SWV for the differentiation of normal liver,background liver parenchyma and lesions.The cut-off point for SWV was obtained by using ROC curve analysis which was used to predict malignancy lesions.Results The SWV of malignant lesions was significantly higher than that of benign ones [(2.83 ± 0.91)m/s vs (1.83 ± 0.64)m/s,P =0.000].The SWV of healthy liver was significantly lower than both malignant and benign lesions(P ＜0.01).Based on 2.19m/s as the cut-off point of SWV value,the sensitivity,specificity,accuracy,positive predictive value and negative predictive value for diagnosing malignancies were 82.5％,75.4％,77.03％,81.16％,78.9％ respectively.Conclusions VTQ technology could provide complementary information regarding the tissue stiffness,which is useful for the differential diagnosis of focal liver lesions.