CAJ | 학술논문

目的超声探讨正常与法洛四联症(tetralogy of Fallot,TOF)胎儿主、肺动脉径线的差异.方法应用时间-空间关联成像技术测量329例正常胎儿和43例TOF胎儿主动脉内径(Ao)及主肺动脉内径(PA),建立正常胎儿Ao、PAz-score模型,比较两组Ao、PAz-score值及PA/Ao值差异.结果两组Ao、PAz-score值及PA/Ao值差异有统计学意义(P＜0.0001),TOF组Ao z-score值均＞+2 z-scores,PA/Ao值均分布于95％ CI之外,48.84％ PA z-score值＜-2 z-scores.结论胎儿时期TOF大血管径线改变以Ao增宽及PA/Ao比值减小为主要表现,有望成为产前超声诊断指标.
목적 초성탐토정상여법락사련증(tetralogy of Fallot,TOF)태인주、폐동맥경선적차이.방법 응용시간-공간관련성상기술측량329례정상태인화43례TOF태인주동맥내경(Ao)급주폐동맥내경(PA),건립정상태인Ao、PAz-score모형,비교량조Ao、PAz-score치급PA/Ao치차이.결과 량조Ao、PAz-score치급PA/Ao치차이유통계학의의(P＜0.0001),TOF조Ao z-score치균＞+2 z-scores,PA/Ao치균분포우95％ CI지외,48.84％ PA z-score치＜-2 z-scores.결론 태인시기TOF대혈관경선개변이Ao증관급PA/Ao비치감소위주요표현,유망성위산전초성진단지표.
Objective To establish z-score model for fetal aorta (Ao) and pulmonary artery (PA) dimensions base on fetal femur length (FL),then to evaluate them in prenatal diagnosis of tetralogy of Fallot (TOF).Methods Three hundred twenty-nine normal fetuses and 43 fetuses with TOF were involved,Ao and PA dimensions were measured for all cases offline after cardio-spatiotemporal image correlation (STIC) volume acquisition,and PA to Ao ratio (PA/Ao) was calculated.Normal Ao and PA dimensions z-score models were constructed by using first standard regression analysis using FL as independent variable.Subsequently,the three parameters between normal and TOF fetuses were compared.Results The models use to calculate z-score for Ao and PA dimensions were constructed,FL had close correlation with fetal Ao and PA dimensions.Compared with normal fetuses,the mean z-scores of Ao,PA and PA/Ao ratio were statistical different in TOF fetuses.All Ao z-scores were ＞ + 2 z-scores and all the PA/Ao ratio were ＜ the 95％ CI in TOF group,however,only 48.84％ (21/43) PA z-scores of TOF cases were ＜-2 z-scores.Conclusions The Ao and PA dimensions z-score can provide quantitative evidence in prenatal diagnosis of TOF.Aortic dilatation and abnormal PA/Ao ratio are the main performances in fetal TOF and would be markers for prenatal diagnosis of TOF.