CAJ | 학술논문

目的定量分析泌尿系结石大小与其所产生的闪烁伪像的相关性.方法采用片剂制药工艺流程制备一水草酸钙、羟基磷灰石、磷酸三钙、L-胱氨酸及尿酸5种成分的泌尿系结石模型,每种均包括10种不同直径(5.0 mm、5.5 mm、6.0 mm、6.5 mm、7.0 mm、7.5 mm、8.0mm、8.5 mm、9.0mm、9.5 mm).将不同成分、不同直径的结石模型包埋于离体猪肾上极集合系统后行彩色多普勒超声扫查,采集闪烁伪像图像,分别测量闪烁伪像长度(TAL)和宽度(TAW),并计算闪烁伪像强度(TAI).结果所有的结石模型后方均产生了较为明显的闪烁伪像,TAI大小为244.00～11 544.00,平均2 998.80;TAI、TAL、TAW与所有结石模型的直径均呈显著正相关(r分别为0.976、0.940、0.974,P＜0.001);TAI与TAL、TAW均呈显著正相关(r分别为0.825、0.779,P＜0.001);多元线性回归分析显示,TAI=-599.48+ 687.07TAL+356.97TAW,TAL和TAW是TAI的独立影响因素(标准回归系数β分别为0.555、0.430,P＜0.001).结论泌尿系结石所产生的闪烁伪像与结石大小密切相关,随着结石大小的增加,闪烁伪像的强度增加;TAL和TAW是TAI的良好预测指标.
목적 정량분석비뇨계결석대소여기소산생적섬삭위상적상관성.방법 채용편제제약공예류정제비일수초산개、간기린회석、린산삼개、L-광안산급뇨산5충성분적비뇨계결석모형,매충균포괄10충불동직경(5.0 mm、5.5 mm、6.0 mm、6.5 mm、7.0 mm、7.5 mm、8.0mm、8.5 mm、9.0mm、9.5 mm).장불동성분、불동직경적결석모형포매우리체저신상겁집합계통후행채색다보륵초성소사,채집섬삭위상도상,분별측량섬삭위상장도(TAL)화관도(TAW),병계산섬삭위상강도(TAI).결과 소유적결석모형후방균산생료교위명현적섬삭위상,TAI대소위244.00～11 544.00,평균2 998.80;TAI、TAL、TAW여소유결석모형적직경균정현저정상관(r분별위0.976、0.940、0.974,P＜0.001);TAI여TAL、TAW균정현저정상관(r분별위0.825、0.779,P＜0.001);다원선성회귀분석현시,TAI=-599.48+ 687.07TAL+356.97TAW,TAL화TAW시TAI적독립영향인소(표준회귀계수β분별위0.555、0.430,P＜0.001).결론 비뇨계결석소산생적섬삭위상여결석대소밀절상관,수착결석대소적증가,섬삭위상적강도증가;TAL화TAW시TAI적량호예측지표.
Objective To quantitatively analyze the correlation between stone size and color Doppler twinkling artifact in urinary stones.Methods Five types of cylinder urinary stone phantoms (calcium oxalate monohydrate,whitlockite,apatite,L cystine,uric acid) were prepared according to standard pharmaceutical preparation protocols.For each type,stone phantoms of ten different standard diameters were prepared(5.0 mm,5.5 mm,6.0 mm,6.5 mm,7.0 mm,7.5 mm,8.0 mm,8.5 mm,9.0 mm,9.5 mm).One stone phantom was selected from those artificial stones with the same composition and diameter and embedded in the collecting systems of porcine kidneys in vitro.Color Doppler ultrasound scanning was performed on the stone phantoms.Color pictures with twinkling artifact were recorded.The length of twinkling artifact (TAL) and the width of twinkling artifact (TAW) were measured and the intensity of twinkling artifact (TAI) was calculated.Results All the stone phantoms generated consistently distinguished twinkling artifact.Of all the stone phantoms,TAI was 244.00-11 544.00,2 998.80 in average.TAI,TAL and TAW were significantly correlated with stone diameter (r =0.976,0.940,0.974 respectively,P ＜0.001) for all the stone phantoms.TAI,TAL and TAW increased with increasing stone diameter.TAL and TAW were significantly correlated with TAI (r =0.825,0.779 respectively,P ＜0.001).Multivariate regression analysis showed that TAI =-599.48 + 687.07TAL + 356.97TAW,TAL and TAW were significant predictive factors for TAI (β =0.555,0.430 respectively,P ＜0.001).Conclusions The appearance of twinkling artifact is highly dependent on stone size.The intensity of twinkling artifact significantly increased with increasing stone size.TAL and TAW are good predictors of TAI.