中华妇产科杂志
中華婦產科雜誌
중화부산과잡지
CHINESE JOUNAL OF OBSTETRICS AND GYNECOLOGY
2013年
1期
25-28
,共4页
叶祎%汪萌%陈克%谢爱兰
葉祎%汪萌%陳剋%謝愛蘭
협의%왕맹%진극%사애란
糖尿病,妊娠%婴儿,新生%胎血%受体,转铁蛋白%转铁蛋白%铁%缺乏症
糖尿病,妊娠%嬰兒,新生%胎血%受體,轉鐵蛋白%轉鐵蛋白%鐵%缺乏癥
당뇨병,임신%영인,신생%태혈%수체,전철단백%전철단백%철%결핍증
Diabetes,gestational%Infant,newborn%Fetai blood%Receptors,transferrin%Transferrin%Iron%Deficiency diseases
目的 探讨妊娠期糖尿病(GDM)孕妇的新生儿是否存在铁缺乏的状况.方法 前瞻性选择2008年6月至2011年10月在温州医学院附属第二医院住院治疗的64例GDM孕妇及其分娩的新生儿作为GDM组；同期71例健康孕妇及其分娩的新生儿作为对照组.检测两组新生儿脐血铁蛋白(SF)、血清转铁蛋白受体(sTfR)、促红细胞生成素(Epo)、血红蛋白(Hb)、血清胰岛素、血糖水平,并测量新生儿出生体质量(BW),计算年龄别体质量评分(WAZ,用中位数表示).同时检测两组孕妇分娩前空腹血清胰岛素(FINS)、空腹血糖(FPG)和糖化血红蛋白(HbAlc)水平.结果 GDM组新生儿脐血sTfR、Epo、血清胰岛素水平分别为(42±10) nmol/L、(56±41) U/L和(18±5)U/L,均明显高于对照组的(35±8)nmol/L、(41±43)U/L和(10±5) U/L,差异均有统计学意义(P＜0.05)；GDM组新生儿脐血SF为(60±36) μg/L,明显低于对照组的(146±38) μg/L,差异有统计学意义(P＜0.01)；GDM组新生儿BW及WAZ分别为(3615±538)g和0.558分,明显高于对照组的(3449±423)g和0.224分,差异均有统计学意义(P＜0.05)；GDM组新生儿脐血糖[(3.3±1.0) mmol/L]和Hb水平[(181±18) g/L]与对照组比较[分别为(3.0±0.8) mmol/L和(176±16) g/L],差异均无统计学意义(P＞0.05).GDM组孕妇分娩前FINS及HbAlc分别为(12.5±5.0) U/L和(6.5±0.7)％,均明显高于对照组的(10.9±4.3) U/L和(5.3±0.7)％,差异均有统计学意义(P＜0.05)；两组孕妇FPG分别为(5.3±1.2)和(5.0±1.0) mmol/L,两组比较,差异无统计学意义(P＞0.05).结论 GDM孕妇分娩的新生儿存在铁缺乏的状况.
目的 探討妊娠期糖尿病(GDM)孕婦的新生兒是否存在鐵缺乏的狀況.方法 前瞻性選擇2008年6月至2011年10月在溫州醫學院附屬第二醫院住院治療的64例GDM孕婦及其分娩的新生兒作為GDM組；同期71例健康孕婦及其分娩的新生兒作為對照組.檢測兩組新生兒臍血鐵蛋白(SF)、血清轉鐵蛋白受體(sTfR)、促紅細胞生成素(Epo)、血紅蛋白(Hb)、血清胰島素、血糖水平,併測量新生兒齣生體質量(BW),計算年齡彆體質量評分(WAZ,用中位數錶示).同時檢測兩組孕婦分娩前空腹血清胰島素(FINS)、空腹血糖(FPG)和糖化血紅蛋白(HbAlc)水平.結果 GDM組新生兒臍血sTfR、Epo、血清胰島素水平分彆為(42±10) nmol/L、(56±41) U/L和(18±5)U/L,均明顯高于對照組的(35±8)nmol/L、(41±43)U/L和(10±5) U/L,差異均有統計學意義(P＜0.05)；GDM組新生兒臍血SF為(60±36) μg/L,明顯低于對照組的(146±38) μg/L,差異有統計學意義(P＜0.01)；GDM組新生兒BW及WAZ分彆為(3615±538)g和0.558分,明顯高于對照組的(3449±423)g和0.224分,差異均有統計學意義(P＜0.05)；GDM組新生兒臍血糖[(3.3±1.0) mmol/L]和Hb水平[(181±18) g/L]與對照組比較[分彆為(3.0±0.8) mmol/L和(176±16) g/L],差異均無統計學意義(P＞0.05).GDM組孕婦分娩前FINS及HbAlc分彆為(12.5±5.0) U/L和(6.5±0.7)％,均明顯高于對照組的(10.9±4.3) U/L和(5.3±0.7)％,差異均有統計學意義(P＜0.05)；兩組孕婦FPG分彆為(5.3±1.2)和(5.0±1.0) mmol/L,兩組比較,差異無統計學意義(P＞0.05).結論 GDM孕婦分娩的新生兒存在鐵缺乏的狀況.
목적 탐토임신기당뇨병(GDM)잉부적신생인시부존재철결핍적상황.방법 전첨성선택2008년6월지2011년10월재온주의학원부속제이의원주원치료적64례GDM잉부급기분면적신생인작위GDM조；동기71례건강잉부급기분면적신생인작위대조조.검측량조신생인제혈철단백(SF)、혈청전철단백수체(sTfR)、촉홍세포생성소(Epo)、혈홍단백(Hb)、혈청이도소、혈당수평,병측량신생인출생체질량(BW),계산년령별체질량평분(WAZ,용중위수표시).동시검측량조잉부분면전공복혈청이도소(FINS)、공복혈당(FPG)화당화혈홍단백(HbAlc)수평.결과 GDM조신생인제혈sTfR、Epo、혈청이도소수평분별위(42±10) nmol/L、(56±41) U/L화(18±5)U/L,균명현고우대조조적(35±8)nmol/L、(41±43)U/L화(10±5) U/L,차이균유통계학의의(P＜0.05)；GDM조신생인제혈SF위(60±36) μg/L,명현저우대조조적(146±38) μg/L,차이유통계학의의(P＜0.01)；GDM조신생인BW급WAZ분별위(3615±538)g화0.558분,명현고우대조조적(3449±423)g화0.224분,차이균유통계학의의(P＜0.05)；GDM조신생인제혈당[(3.3±1.0) mmol/L]화Hb수평[(181±18) g/L]여대조조비교[분별위(3.0±0.8) mmol/L화(176±16) g/L],차이균무통계학의의(P＞0.05).GDM조잉부분면전FINS급HbAlc분별위(12.5±5.0) U/L화(6.5±0.7)％,균명현고우대조조적(10.9±4.3) U/L화(5.3±0.7)％,차이균유통계학의의(P＜0.05)；량조잉부FPG분별위(5.3±1.2)화(5.0±1.0) mmol/L,량조비교,차이무통계학의의(P＞0.05).결론 GDM잉부분면적신생인존재철결핍적상황.
Objective To investigate the iron status in the newborns of maternal gestational diabetes mellitus(GDM) women,and explore the mechanism of iron deficiency in these newborns.Methods From June 2008 to October 2011,64 GDM women (GDM group) and 71 healthy pregnant women (control group)who delivered in the Second Affiliated Hospital of Wenzhou Medical College and their newborns were studied prospectively.Serum ferritin (SF),serum transferrin receptor (sTfR),erythropoietin (Epo),haemoglobin (Hb),serum level of insulin and plasma glucose in cord blood was measured.The neonatal birth weight (BW) and birth weight Z Score(WAZ) was recorded.The concentrations of serum fasting insulin (FINS),fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c)were tested for all the women before delivery.Results In the GDM group,the cord blood sTfR,Epo and serum level of insulin was (42 ± 10)nmol/L,(56 ±41) U/L and(18 ± 5) U/L,respectively.While in the control group,these were(35 ± 8)nmol/L,(41 ± 43) U/L and (10 ± 5) U/L,respectively.The cord blood sTfR,Epo and serum level of insulin in the GDM group were significantly higher than those in the control group (P ＜ 0.05).The cord blood SF in the GDM group[(60 ±36) μg/L] was significantly lower than that of the control group[(146 ±38) μg/L,P ＜ 0.01].The neonatal BW and WAZ in the GDM group [(3615 ± 538) g and 0.558] were significantly higher than those in the control group [(3449 ± 423) g and 0.224,P ＜ 0.05].No significant difference was found in the cord blood plasma glucose and Hb between the GDM group[(3.3 ± 1.0) mmol/L and (181 ± 18) g/L] and the control group [(3.0 ± 0.8) mmol/L and (176 ± 16) g/L,P ＞ 0.05].The FINS and HbA1c of the GDM group[(12.5 ±5.0) U/L and (6.5 ±0.7)％] were significantly higher than those in the control group [(10.9 ± 4.3) U/L and (5.3 ± 0.7) ％,P ＜ 0.05].The FPG of the GDM group and the control group were (5.3 ± 1.2) and (5.0 ± 1.0) mmol/L,respectively,with no statistically significant difference (P ＞ 0.05).Conclusion Maternal GDM may related to the iron deficiency of the newborns.
