中华妇产科杂志
中華婦產科雜誌
중화부산과잡지
CHINESE JOUNAL OF OBSTETRICS AND GYNECOLOGY
2013年
6期
427-431
,共5页
赵晓苗%倪仁敏%黄佳%黄丽丽%杜尚明%马梦君%林淡钰%杨冬梓
趙曉苗%倪仁敏%黃佳%黃麗麗%杜尚明%馬夢君%林淡鈺%楊鼕梓
조효묘%예인민%황가%황려려%두상명%마몽군%림담옥%양동재
多毛症%多囊卵巢综合征%毛发%横断面研究%聚类分析%试验预期值%疾病严重程度指数%汉族
多毛癥%多囊卵巢綜閤徵%毛髮%橫斷麵研究%聚類分析%試驗預期值%疾病嚴重程度指數%漢族
다모증%다낭란소종합정%모발%횡단면연구%취류분석%시험예기치%질병엄중정도지수%한족
Hirsutism%Polycystic ovary syndrome%Hair%Cross-sectional studies%Cluster analysis%Predictive value of tests%Severity of illness index%Han nationality
目的 了解广东省育龄期汉族妇女体毛生长状况,探讨年龄、月经紊乱以及多囊卵巢对终毛生长状况的影响,并提出改良Ferriman-Gallwey (mFG)评分系统对多毛症的评分诊断界值.方法 2008年6月至2009年7月采用四级系统随机抽样的方法,抽取广东省两个城市和两个农村共16个社区的育龄期(20 ～ 45岁)妇女2988例,采用mFG评分系统对体毛分布进行评价,并用K-聚类分析法计算多毛症的诊断界值.按照不同的年龄分组(20～岁组982例、26～岁组765例、31～岁组597例、36～岁组384例、41～45岁组260例)；因部分数据记录错误或缺失,导致部分病例从组别中删除,最终根据有、无月经紊乱,有、无多囊卵巢分为月经紊乱组488例、月经正常组2413例,多囊卵巢组568例、非多囊卵巢组2207例,比较各组多毛症mFG评分系统诊断界值,以及各组多毛症妇女痤疮、月经紊乱、黑棘皮症和多囊卵巢的发生率.结果 (1)在2988例妇女中,mFG评分系统≥7分149例(5.0％),≥5分314例(10.5％),≥2分747例(25.0％).(2)在总人群中,多毛症mFG评分系统诊断界值为≥5分；月经紊乱组和多囊卵巢组mFG评分系统评分第90、95百分位数均分别低于月经正常组、非多囊卵巢组(P均＜0.05).(3)年龄分组结果显示:mFG评分系统相应百分位数和多毛症诊断界值均随着年龄增加而下降(P＜0.05)；多毛症mFG评分系统诊断界值在20～岁组为≥6分,26～岁组为≥5分,而31～岁组、36～岁组、41 ～45岁组则均为≥4分.(4)总人群中多毛症妇女痤疮、月经紊乱、多囊卵巢发生率分别为45.5％ (143/314)、73.6％ (231/314)、25.8％ (81/314),正常毛发妇女分别为25.1％(671/2674)、16.1％ (431/2674)、19.8％(529/2674),两者分别比较,差异均有统计学意义(P＜0.05)；各年龄组多毛症妇女痤疮、月经紊乱、黑棘皮症发生率分别为44.4％(130/293)、23.2％(68/293)、4.1％(12/293),正常毛发妇女分别为25.3％(681/2695)、16.2％(437/2695)、1.9％ (51/2695),两者分别比较,差异均有统计学意义(P＜0.05).结论 (1) mFG评分系统评价广东省育龄期汉族妇女的体毛生长程度随着年龄增加而降低.(2)mFG≥5分为多毛症诊断界值.(3)多毛症妇女痤疮、月经紊乱及多囊卵巢发生率明显升高.
目的 瞭解廣東省育齡期漢族婦女體毛生長狀況,探討年齡、月經紊亂以及多囊卵巢對終毛生長狀況的影響,併提齣改良Ferriman-Gallwey (mFG)評分繫統對多毛癥的評分診斷界值.方法 2008年6月至2009年7月採用四級繫統隨機抽樣的方法,抽取廣東省兩箇城市和兩箇農村共16箇社區的育齡期(20 ～ 45歲)婦女2988例,採用mFG評分繫統對體毛分佈進行評價,併用K-聚類分析法計算多毛癥的診斷界值.按照不同的年齡分組(20～歲組982例、26～歲組765例、31～歲組597例、36～歲組384例、41～45歲組260例)；因部分數據記錄錯誤或缺失,導緻部分病例從組彆中刪除,最終根據有、無月經紊亂,有、無多囊卵巢分為月經紊亂組488例、月經正常組2413例,多囊卵巢組568例、非多囊卵巢組2207例,比較各組多毛癥mFG評分繫統診斷界值,以及各組多毛癥婦女痤瘡、月經紊亂、黑棘皮癥和多囊卵巢的髮生率.結果 (1)在2988例婦女中,mFG評分繫統≥7分149例(5.0％),≥5分314例(10.5％),≥2分747例(25.0％).(2)在總人群中,多毛癥mFG評分繫統診斷界值為≥5分；月經紊亂組和多囊卵巢組mFG評分繫統評分第90、95百分位數均分彆低于月經正常組、非多囊卵巢組(P均＜0.05).(3)年齡分組結果顯示:mFG評分繫統相應百分位數和多毛癥診斷界值均隨著年齡增加而下降(P＜0.05)；多毛癥mFG評分繫統診斷界值在20～歲組為≥6分,26～歲組為≥5分,而31～歲組、36～歲組、41 ～45歲組則均為≥4分.(4)總人群中多毛癥婦女痤瘡、月經紊亂、多囊卵巢髮生率分彆為45.5％ (143/314)、73.6％ (231/314)、25.8％ (81/314),正常毛髮婦女分彆為25.1％(671/2674)、16.1％ (431/2674)、19.8％(529/2674),兩者分彆比較,差異均有統計學意義(P＜0.05)；各年齡組多毛癥婦女痤瘡、月經紊亂、黑棘皮癥髮生率分彆為44.4％(130/293)、23.2％(68/293)、4.1％(12/293),正常毛髮婦女分彆為25.3％(681/2695)、16.2％(437/2695)、1.9％ (51/2695),兩者分彆比較,差異均有統計學意義(P＜0.05).結論 (1) mFG評分繫統評價廣東省育齡期漢族婦女的體毛生長程度隨著年齡增加而降低.(2)mFG≥5分為多毛癥診斷界值.(3)多毛癥婦女痤瘡、月經紊亂及多囊卵巢髮生率明顯升高.
목적 료해광동성육령기한족부녀체모생장상황,탐토년령、월경문란이급다낭란소대종모생장상황적영향,병제출개량Ferriman-Gallwey (mFG)평분계통대다모증적평분진단계치.방법 2008년6월지2009년7월채용사급계통수궤추양적방법,추취광동성량개성시화량개농촌공16개사구적육령기(20 ～ 45세)부녀2988례,채용mFG평분계통대체모분포진행평개,병용K-취류분석법계산다모증적진단계치.안조불동적년령분조(20～세조982례、26～세조765례、31～세조597례、36～세조384례、41～45세조260례)；인부분수거기록착오혹결실,도치부분병례종조별중산제,최종근거유、무월경문란,유、무다낭란소분위월경문란조488례、월경정상조2413례,다낭란소조568례、비다낭란소조2207례,비교각조다모증mFG평분계통진단계치,이급각조다모증부녀좌창、월경문란、흑극피증화다낭란소적발생솔.결과 (1)재2988례부녀중,mFG평분계통≥7분149례(5.0％),≥5분314례(10.5％),≥2분747례(25.0％).(2)재총인군중,다모증mFG평분계통진단계치위≥5분；월경문란조화다낭란소조mFG평분계통평분제90、95백분위수균분별저우월경정상조、비다낭란소조(P균＜0.05).(3)년령분조결과현시:mFG평분계통상응백분위수화다모증진단계치균수착년령증가이하강(P＜0.05)；다모증mFG평분계통진단계치재20～세조위≥6분,26～세조위≥5분,이31～세조、36～세조、41 ～45세조칙균위≥4분.(4)총인군중다모증부녀좌창、월경문란、다낭란소발생솔분별위45.5％ (143/314)、73.6％ (231/314)、25.8％ (81/314),정상모발부녀분별위25.1％(671/2674)、16.1％ (431/2674)、19.8％(529/2674),량자분별비교,차이균유통계학의의(P＜0.05)；각년령조다모증부녀좌창、월경문란、흑극피증발생솔분별위44.4％(130/293)、23.2％(68/293)、4.1％(12/293),정상모발부녀분별위25.3％(681/2695)、16.2％(437/2695)、1.9％ (51/2695),량자분별비교,차이균유통계학의의(P＜0.05).결론 (1) mFG평분계통평개광동성육령기한족부녀적체모생장정도수착년령증가이강저.(2)mFG≥5분위다모증진단계치.(3)다모증부녀좌창、월경문란급다낭란소발생솔명현승고.
Objective To study growth of facial and body terminal hair of women in Guangdong province and its relationship with age,menstrual irregularities and polycystic ovary,and determine normative cut-off score of modified Ferriman and Gallwey (mFG).Methods A cross-sectional study was conducted on 2988 women at age of 20-45 years from 16 communities of two urban and two rural regions in Guangdong province from June 2008 to July 2009.Terminal body hair growth was assessed by using the modified Ferriman and Gallwey (mFG) scoring system.The normative cut-off value of mFG were calculated by using the K-means cluster analysis (K =2).Those women were classified into following groups,including 982 women at group of ages of 20-years,765 women at group of 26-years,597 women at group of 31-years,384 women at group of 36-years,260 women at group of 41-45 years.Due to absence or errors of medical records,some cases were excluded from this study.Based on menses irregularities (MI),polycystic ovaries (PCO),there were 488 cases in MI group,2413 cases in normal menses group,568 cases in PCO group,and 2207 cases in non-PCO group finally.The incidences of acne,MI,acanthosis nigricans,and polycystic ovaries were also analyzed in all the hirsute groups.Results (1) among 2988 women,it was observed 149women (5％) with mFG ≥7,314 women (10.5％) with ≥ 5,747 women with mFG≥2.(2) Cluster analysis identified an mFG score of 5 as the cut-off value that define abnormal hirsute in the total population and all the sub-groups with/without MI or PCO; (3) Based on age classification,it was found that increased age was associated with decreased trends of the percentile and cut-off value of hirsutism.The value of hirsutism of mFG were 6 in group of 20-years,5 in group of 26-years,4 in groups of 31-years,36-years and 41-45 years.(4) The prevalence of acne,menstrual irregularities and POC were 45.5％ (143/314),73.6％ (231/314),25.8％ (81/314) in total population,25.1％ (671/2674),16.1％ (431/2674),19.8％ (529/2674)in normal hair women,which reached statistical difference (P ＜ 0.05).The prevalence of acne,menstrual irregularities and acanthosis nigricans were 44.4％ (130/293),23.2％ (68/293),4.1％ (12/293) in those age hirsute groups,25.3 ％ (681/2695),16.2％ (437/2695),1.9％ (51/2695)in normal hair women,which reached statistical difference (P ＜ 0.05).Conclusions (1) among women in Guangdong province,mFG scoring showed decreased trends in women with increasing age.(2) An mFG score ≥ 5 was cut-off value in diagnosis of hirsutism.(3) The hirsute women exhibited higher incidence of acne,menses irregularity,and acanthosis nigricans than those of women with normal hair growth.
