中华妇产科杂志
中華婦產科雜誌
중화부산과잡지
CHINESE JOUNAL OF OBSTETRICS AND GYNECOLOGY
2013年
12期
903-906
,共4页
于红玲%邓晓惠%晁岚%陈超%韩亦龙
于紅玲%鄧曉惠%晁嵐%陳超%韓亦龍
우홍령%산효혜%조람%진초%한역룡
流产,习惯性%免疫疗法,过继%免疫球蛋白G
流產,習慣性%免疫療法,過繼%免疫毬蛋白G
유산,습관성%면역요법,과계%면역구단백G
Abortion,habitual%Immunotherapy,adoptive%Immunoglobulin G
目的 探讨配偶淋巴细胞免疫治疗次数和注射方式对复发性流产患者封闭抗体转阳率的影响.方法 回顾性分析2008年1月至2012年8月在山东大学齐鲁医院不孕不育诊疗中心进行配偶淋巴细胞免疫治疗的复发性流产患者326例的临床资料,共分为两组,皮内注射组260例,采用双侧前臂皮内注射法进行淋巴细胞免疫治疗,每21天1次,并分别于免疫治疗2(23例)、3(73例)、4(74例)、5(90例)次后2周测定封闭抗体;皮下注射组66例,采用皮下注射法,进行淋巴细胞免疫治疗,同样为每21天1次,治疗5次,并于治疗第3次后2周测定封闭抗体.计算封闭抗体转阳率,随访并计算封闭抗体转阳后再次妊娠的成功率.结果 (1)封闭抗体转阳率:皮内注射组2、3、4、5次免疫治疗后,封闭抗体转阳率分别为17％(4/23)、58％(42/73) 、72％(53/74)、84％(76/90),分别比较,差异均有统计学意义(P＜0.05).免疫治疗3次后皮下注射组封闭抗体转阳率为38％(25/66),明显低于皮内注射组的封闭抗体转阳率(58％,42/73),差异也有统计学意义(P＜0.05).(2)封闭抗体转阳患者的妊娠率:封闭抗体转阳的200例患者中,妊娠176例,其中成功妊娠(妊娠而且时间≥5个月)126例,11例妊娠但时间＜5个月,成功妊娠率为71.6％ (126/176),流产39例.结论 免疫治疗次数和注射方式影响封闭抗体转阳率;封闭抗体转阳后可提高再次妊娠的成功率.
目的 探討配偶淋巴細胞免疫治療次數和註射方式對複髮性流產患者封閉抗體轉暘率的影響.方法 迴顧性分析2008年1月至2012年8月在山東大學齊魯醫院不孕不育診療中心進行配偶淋巴細胞免疫治療的複髮性流產患者326例的臨床資料,共分為兩組,皮內註射組260例,採用雙側前臂皮內註射法進行淋巴細胞免疫治療,每21天1次,併分彆于免疫治療2(23例)、3(73例)、4(74例)、5(90例)次後2週測定封閉抗體;皮下註射組66例,採用皮下註射法,進行淋巴細胞免疫治療,同樣為每21天1次,治療5次,併于治療第3次後2週測定封閉抗體.計算封閉抗體轉暘率,隨訪併計算封閉抗體轉暘後再次妊娠的成功率.結果 (1)封閉抗體轉暘率:皮內註射組2、3、4、5次免疫治療後,封閉抗體轉暘率分彆為17％(4/23)、58％(42/73) 、72％(53/74)、84％(76/90),分彆比較,差異均有統計學意義(P＜0.05).免疫治療3次後皮下註射組封閉抗體轉暘率為38％(25/66),明顯低于皮內註射組的封閉抗體轉暘率(58％,42/73),差異也有統計學意義(P＜0.05).(2)封閉抗體轉暘患者的妊娠率:封閉抗體轉暘的200例患者中,妊娠176例,其中成功妊娠(妊娠而且時間≥5箇月)126例,11例妊娠但時間＜5箇月,成功妊娠率為71.6％ (126/176),流產39例.結論 免疫治療次數和註射方式影響封閉抗體轉暘率;封閉抗體轉暘後可提高再次妊娠的成功率.
목적 탐토배우림파세포면역치료차수화주사방식대복발성유산환자봉폐항체전양솔적영향.방법 회고성분석2008년1월지2012년8월재산동대학제로의원불잉불육진료중심진행배우림파세포면역치료적복발성유산환자326례적림상자료,공분위량조,피내주사조260례,채용쌍측전비피내주사법진행림파세포면역치료,매21천1차,병분별우면역치료2(23례)、3(73례)、4(74례)、5(90례)차후2주측정봉폐항체;피하주사조66례,채용피하주사법,진행림파세포면역치료,동양위매21천1차,치료5차,병우치료제3차후2주측정봉폐항체.계산봉폐항체전양솔,수방병계산봉폐항체전양후재차임신적성공솔.결과 (1)봉폐항체전양솔:피내주사조2、3、4、5차면역치료후,봉폐항체전양솔분별위17％(4/23)、58％(42/73) 、72％(53/74)、84％(76/90),분별비교,차이균유통계학의의(P＜0.05).면역치료3차후피하주사조봉폐항체전양솔위38％(25/66),명현저우피내주사조적봉폐항체전양솔(58％,42/73),차이야유통계학의의(P＜0.05).(2)봉폐항체전양환자적임신솔:봉폐항체전양적200례환자중,임신176례,기중성공임신(임신이차시간≥5개월)126례,11례임신단시간＜5개월,성공임신솔위71.6％ (126/176),유산39례.결론 면역치료차수화주사방식영향봉폐항체전양솔;봉폐항체전양후가제고재차임신적성공솔.
Objective To investigates factors affecting the positive rate of blocking antibody treated by paternal lymphocyte immunotherapy in patients with recurrent spontaneous abortion (RSA).Methods From January 2008 to August 2012,326 RSA cases undergoing treatment in Infertility Center of Qilu Hospital were studied retrospectively.Those patients were divided into 2 groups randomly:260 cases in intradermal injection group were administered via bilateral forearm intradermal injections for immunotherapy once 21 days,then the blocking antibody was determined after 2 (23 cases),3 (73 cases),4 (74 cases),5(90 cases) times respectively,while in subcutaneous injection group,the 66 cases were administered via subcutaneous injection once 21 days,the blocking antibody measured after 3 times; In both cases,the blocking antibody was all determined 2 weeks later.The positive rate of blocking antibodies and the rate of successful pregnancy was recorded,and then followed up after the blocking antibody turning positive.Results (1)Positive rate of blocking antibodies:the positive rate of blocking antibodies were 17％ (4/23),58％ (42/73),72％ (53/74) and 84％ (76/90) in the 2,3,4,and 5 times of intradermal injection group,respectively (P ＜ 0.05).In subcutaneous injection group,the positive rate of blocking antibodies was 38 ％ (25/66),which was significantly lower than that in group intradermal injection receiving 3 times immunotherapy (P ＜0.05).(2) The rate of pregnancy:the 176 patients out of 200 patients were pregnant when antibody was positive after immunotherapy,with 71.6％ (126/176)of patients gained successful pregnancy(the length of pregnancy more than 5 months).Conclusions The route and frequency of administration of immunotherapy could influence the positive rate of blocking antibody.The rate of successful pregnancy will be increased after blocking antibody turning positive.
