中华妇产科杂志
中華婦產科雜誌
중화부산과잡지
CHINESE JOUNAL OF OBSTETRICS AND GYNECOLOGY
2013年
12期
925-928
,共4页
袁光文%吴令英%张蓉%李晓光
袁光文%吳令英%張蓉%李曉光
원광문%오령영%장용%리효광
外阴肿瘤%Bowen病%妇科外科手术
外陰腫瘤%Bowen病%婦科外科手術
외음종류%Bowen병%부과외과수술
Vulvar neoplasms%Bowen's disease%Gynecologic surgical procedures
目的 探讨外阴鲍文病的临床病理特点、诊断、治疗及预后.方法 收集1991年1月至2011年6月间中国医学科学院肿瘤医院收治的18例外阴鲍文病患者的临床病理资料,回顾性分析其临床病理特点、诊断、治疗方式及预后情况.结果 18例患者的中位年龄为37岁(23 ～64岁);16例患者伴有外阴瘙痒,仅有2例无明显症状;5例为单发病灶,13例为多发病灶.外阴鲍文病的诊断主要依靠病理检查,其特征性表现为在表皮全层可见多少不一的单核有异型性的圆形或卵圆形大细胞(即鲍文细胞).18例患者均采用手术治疗,其中11例采用单纯外阴切除术,7例采用外阴病灶局部扩大切除术.中位随访时间为123个月(5 ～ 197个月),2例出现复发,均为外阴病灶局部扩大切除术后复发,其中l例于术后5个月复发,再次手术行单纯外阴切除术,术后随访192个月未复发;另1例于术后15个月复发,再次手术仍行病灶局部扩大切除术,术后随访55个月未复发.结论 外阴鲍文病的临床表现无特异性,其病理特征性表现为表皮全层可见多少不一的鲍文细胞,诊断主要依靠组织病理学检查,治疗以手术治疗为主,疗效肯定,患者的预后良好.
目的 探討外陰鮑文病的臨床病理特點、診斷、治療及預後.方法 收集1991年1月至2011年6月間中國醫學科學院腫瘤醫院收治的18例外陰鮑文病患者的臨床病理資料,迴顧性分析其臨床病理特點、診斷、治療方式及預後情況.結果 18例患者的中位年齡為37歲(23 ～64歲);16例患者伴有外陰瘙癢,僅有2例無明顯癥狀;5例為單髮病竈,13例為多髮病竈.外陰鮑文病的診斷主要依靠病理檢查,其特徵性錶現為在錶皮全層可見多少不一的單覈有異型性的圓形或卵圓形大細胞(即鮑文細胞).18例患者均採用手術治療,其中11例採用單純外陰切除術,7例採用外陰病竈跼部擴大切除術.中位隨訪時間為123箇月(5 ～ 197箇月),2例齣現複髮,均為外陰病竈跼部擴大切除術後複髮,其中l例于術後5箇月複髮,再次手術行單純外陰切除術,術後隨訪192箇月未複髮;另1例于術後15箇月複髮,再次手術仍行病竈跼部擴大切除術,術後隨訪55箇月未複髮.結論 外陰鮑文病的臨床錶現無特異性,其病理特徵性錶現為錶皮全層可見多少不一的鮑文細胞,診斷主要依靠組織病理學檢查,治療以手術治療為主,療效肯定,患者的預後良好.
목적 탐토외음포문병적림상병리특점、진단、치료급예후.방법 수집1991년1월지2011년6월간중국의학과학원종류의원수치적18예외음포문병환자적림상병리자료,회고성분석기림상병리특점、진단、치료방식급예후정황.결과 18례환자적중위년령위37세(23 ～64세);16례환자반유외음소양,부유2례무명현증상;5례위단발병조,13례위다발병조.외음포문병적진단주요의고병리검사,기특정성표현위재표피전층가견다소불일적단핵유이형성적원형혹란원형대세포(즉포문세포).18례환자균채용수술치료,기중11례채용단순외음절제술,7례채용외음병조국부확대절제술.중위수방시간위123개월(5 ～ 197개월),2례출현복발,균위외음병조국부확대절제술후복발,기중l례우술후5개월복발,재차수술행단순외음절제술,술후수방192개월미복발;령1례우술후15개월복발,재차수술잉행병조국부확대절제술,술후수방55개월미복발.결론 외음포문병적림상표현무특이성,기병리특정성표현위표피전층가견다소불일적포문세포,진단주요의고조직병이학검사,치료이수술치료위주,료효긍정,환자적예후량호.
Objective To analyse the clinical and pathological characteristics,diagnosis,treatment and prognosis of vulvar Bowen's disease.Methods Clinical data including pathological characteristics,diagnosis,treatment methods and follow-up of 18 cases with vulvar Bowen's disease admitted to Cancer Hospital,Chinese Academy of Medical Sciences during January 1991 to June 2011 were retrospectively analyzed.Results The median age of the 18 patients was 37 years (range:23 to 64 years).Sixteen patients had symptoms of vulvar itching and two patients had no symptom.Five cases were single neoplasm focus and the other 13 cases were multiple focuses.The diagnosis of vulvar Bowen's disease was according to the pathological diagnosis.Its diagnostic characteristic was giant round or ovoid cells with mono nucleolus in the whole layer of epidermis.All the patients received operation,eleven with simple vulvectomy and other seven cases with lumpectomy.The median follow-up time was 123 months (range:5 to 197 months).Relapse was found in two cases.One patient relapsed five months postoperation and received vulvectomy.Another patient relapsed fifteen moths post-operation and received lumpectomy again.And they were follow-up for 192months and 55 months respectively after second operation without relapse.Conclusions The diagnostic characteristic of vulvar Bowen's disease is giant round or ovoid cell with mono nucleolus in the whole layer of epidermis,itsdiagnosis is according to the pathological diagnosis.Operation could get very good curative effect for patients with primary vulvar Bowen's disease and even for the recurrent patients.The prognosis of vulvar Bowen's disease is good.
