中华风湿病学杂志
中華風濕病學雜誌
중화풍습병학잡지
CHINESE JOURNAL OF RHEUMATOLOGY
2012年
11期
724-727
,共4页
陈义磊%张闽光%王俊%詹迎江%陈建础
陳義磊%張閩光%王俊%詹迎江%陳建礎
진의뢰%장민광%왕준%첨영강%진건출
干燥综合征%体层摄影术,X线计算机%肺动脉高压%抗SSB抗体
榦燥綜閤徵%體層攝影術,X線計算機%肺動脈高壓%抗SSB抗體
간조종합정%체층섭영술,X선계산궤%폐동맥고압%항SSB항체
Sj(o)gren's syndrome%Tomography,X-ray computed%Pulmonary arterial hypertension%SSB antibodies
目的 探讨原发性干燥综合征(pSS)患者肺部CT表现及临床意义.方法 回顾性分析68例pSS患者肺部CT图像,观察各种病变的分布特征.用CT视觉评分方法定量分析肺内病变,并用二分类非条件Logistic回归分析探讨与pSS患者肺动脉高压(PAH)、抗SSB抗体阳性的关系.结果 68例pSS患者PAH 13例(19%),抗SSB抗体阳性25例(37%),肺部CT表现正常13例(19%),小叶间隔增厚、磨玻璃影、小叶内间质增厚在本组病例中出现的频率较高(>40%).肺内病变分布具有周围分布、下肺分布为主的特点.小叶间隔增厚、囊性变与pSS患者PAH相关(OR=1.780、2.513,P<0.05),囊性变与患者抗SSB抗体阳性有明显相关性(OR=10.530,P<0.05).结论 肺部CT可以定量分析pSS肺损害的程度,并能为临床治疗及预后提供帮助.
目的 探討原髮性榦燥綜閤徵(pSS)患者肺部CT錶現及臨床意義.方法 迴顧性分析68例pSS患者肺部CT圖像,觀察各種病變的分佈特徵.用CT視覺評分方法定量分析肺內病變,併用二分類非條件Logistic迴歸分析探討與pSS患者肺動脈高壓(PAH)、抗SSB抗體暘性的關繫.結果 68例pSS患者PAH 13例(19%),抗SSB抗體暘性25例(37%),肺部CT錶現正常13例(19%),小葉間隔增厚、磨玻璃影、小葉內間質增厚在本組病例中齣現的頻率較高(>40%).肺內病變分佈具有週圍分佈、下肺分佈為主的特點.小葉間隔增厚、囊性變與pSS患者PAH相關(OR=1.780、2.513,P<0.05),囊性變與患者抗SSB抗體暘性有明顯相關性(OR=10.530,P<0.05).結論 肺部CT可以定量分析pSS肺損害的程度,併能為臨床治療及預後提供幫助.
목적 탐토원발성간조종합정(pSS)환자폐부CT표현급림상의의.방법 회고성분석68례pSS환자폐부CT도상,관찰각충병변적분포특정.용CT시각평분방법정량분석폐내병변,병용이분류비조건Logistic회귀분석탐토여pSS환자폐동맥고압(PAH)、항SSB항체양성적관계.결과 68례pSS환자PAH 13례(19%),항SSB항체양성25례(37%),폐부CT표현정상13례(19%),소협간격증후、마파리영、소협내간질증후재본조병례중출현적빈솔교고(>40%).폐내병변분포구유주위분포、하폐분포위주적특점.소협간격증후、낭성변여pSS환자PAH상관(OR=1.780、2.513,P<0.05),낭성변여환자항SSB항체양성유명현상관성(OR=10.530,P<0.05).결론 폐부CT가이정량분석pSS폐손해적정도,병능위림상치료급예후제공방조.
Objective To investigate the lung CT findings in patients with primary Sj(o)gren's syndrome (pSS) and clinical significance.Methods Images of lung CT scans of 68 patients with pSS were retrospectively observed.The distribution characteristics of lung lesions were observed.CT visual score were used to quantitatively analyze lung lesions.Binary classification unconditional logistic regression analysis was used to investigate the relationship between pulmonary arterial hypertension (PAH) and anti-SSB seropositivity in Patients with pSS.Results The 68 cases of patients with pSS,PAH in 13 (19%),anti-SSB seropositivity in 25(37%),CT shows normal in 13 (19%),interlobular septal thickening,ground-glass opacity and intralobular interstitial thickening were frequent findings.The lesion distribution was in the peripheral and lower lung fields.Interlobular septal thickening and cysts were associated with PAH in Patients with pSS (OR=1.780,2.513,P<0.05),cysts was significantly associated with anti-SSB seropositivity (OR =10.530,P<0.05).Conclusion Lung CT can quantitatively analyze the degree of pSS lung damage,and provide helps for clinical treatment and prognosis.