中华风湿病学杂志
中華風濕病學雜誌
중화풍습병학잡지
CHINESE JOURNAL OF RHEUMATOLOGY
2012年
12期
830-832
,共3页
徐传辉%周德训%朱雷%安培%穆荣%高占成%栗占国
徐傳輝%週德訓%硃雷%安培%穆榮%高佔成%慄佔國
서전휘%주덕훈%주뢰%안배%목영%고점성%률점국
风湿性疾病%肺疾病,间质性%免疫球蛋白G%支气管肺泡灌洗液
風濕性疾病%肺疾病,間質性%免疫毬蛋白G%支氣管肺泡灌洗液
풍습성질병%폐질병,간질성%면역구단백G%지기관폐포관세액
Rheumatic diseases%Lung diseases,interstitial%Immunoglobulin G%Bronchoalveolar lavage fluid
目的 了解风湿病相关间质性肺疾病(RD-ILD)患者肺泡灌洗液(BALF)中IgG4水平的临床意义.方法 连续留取北京大学人民医院18例RD-ILD、14例肺部感染和12例非感染患者的BALF,收集临床及实验室资料.酶联免疫吸试验(ELISA)方法检测BALF中IgG4表达水平,并分析其与BALF细胞分类计数和肺功能指标的相关性.定量资料的统计分析采用t检验,两变量间的相关性分析采用线性回归分析.结果 RD-ILD患者BALF中IgG4水平为(87±39) mg/L,显著高于非感染患者的(52±27) mg/L,但与肺部感染患者的(88±65) mg/L比较差异无统计学意义.RD-ILD患者BALF中IgG4水平与淋巴细胞计数比例呈正相关(r=0.53,P=0.03),与巨噬细胞计数比例呈负相关(r=-0.65,P=0.005).结论 RD-ILD患者BALF中的IgG4显著高于非感染患者.IgG4的产生可能主要来源于肺组织中的淋巴细胞.
目的 瞭解風濕病相關間質性肺疾病(RD-ILD)患者肺泡灌洗液(BALF)中IgG4水平的臨床意義.方法 連續留取北京大學人民醫院18例RD-ILD、14例肺部感染和12例非感染患者的BALF,收集臨床及實驗室資料.酶聯免疫吸試驗(ELISA)方法檢測BALF中IgG4錶達水平,併分析其與BALF細胞分類計數和肺功能指標的相關性.定量資料的統計分析採用t檢驗,兩變量間的相關性分析採用線性迴歸分析.結果 RD-ILD患者BALF中IgG4水平為(87±39) mg/L,顯著高于非感染患者的(52±27) mg/L,但與肺部感染患者的(88±65) mg/L比較差異無統計學意義.RD-ILD患者BALF中IgG4水平與淋巴細胞計數比例呈正相關(r=0.53,P=0.03),與巨噬細胞計數比例呈負相關(r=-0.65,P=0.005).結論 RD-ILD患者BALF中的IgG4顯著高于非感染患者.IgG4的產生可能主要來源于肺組織中的淋巴細胞.
목적 료해풍습병상관간질성폐질병(RD-ILD)환자폐포관세액(BALF)중IgG4수평적림상의의.방법 련속류취북경대학인민의원18례RD-ILD、14례폐부감염화12례비감염환자적BALF,수집림상급실험실자료.매련면역흡시험(ELISA)방법검측BALF중IgG4표체수평,병분석기여BALF세포분류계수화폐공능지표적상관성.정량자료적통계분석채용t검험,량변량간적상관성분석채용선성회귀분석.결과 RD-ILD환자BALF중IgG4수평위(87±39) mg/L,현저고우비감염환자적(52±27) mg/L,단여폐부감염환자적(88±65) mg/L비교차이무통계학의의.RD-ILD환자BALF중IgG4수평여림파세포계수비례정정상관(r=0.53,P=0.03),여거서세포계수비례정부상관(r=-0.65,P=0.005).결론 RD-ILD환자BALF중적IgG4현저고우비감염환자.IgG4적산생가능주요래원우폐조직중적림파세포.
Objective To evaluate the clinical significance of the level of [gG4 in the bronchoalveolar lavage fluid (BALF) of patients with rheumatic disease related interstitial lung disease (RD-ILD).Methods Eighteen patients with RD-ILD,14 patients with pulmonary infection and 12 patients without ILD or pulmonary infection,were recruited consecutively from the in-patient ward of Peking University People's Hospital.Clinical features and laboratory data were extracted from the medical record database of Peking University People's Hospital.The level of IgG4 was determined by ELISA.The statistical analysis of data using t test,and the correlation between the two variables were analyzed using linear regression analysis.Results The level of IgG4 was significantly higher in BALF of patients with RD-ILD than patients' without ILD or pulmonary infection,whereas there was no difference compared to patients with pulmonary infection.The level of IgG4 in BALF of patients with RD-ILD was positively correlated with the percentage of lymphocytes (r=0.53,P=0.03),and significantly negatively correlated with the percentage of macrophages (r=-0.65,P=0.005).Conclusion The level of IgG4 is significantly elevated in BALF of patients with RD-ILD,which is probably secreted from the lymphocyte of the lung.
