中华风湿病学杂志
中華風濕病學雜誌
중화풍습병학잡지
CHINESE JOURNAL OF RHEUMATOLOGY
2013年
2期
76-79
,共4页
刘曦%许菁%胡成栋%潘正论%张源潮
劉晞%許菁%鬍成棟%潘正論%張源潮
류희%허정%호성동%반정론%장원조
关节炎,类风湿%多态性,单核苷酸%疾病易感性%TNF受体相关因子6%受体,白细胞介素6%髓样分化因子88
關節炎,類風濕%多態性,單覈苷痠%疾病易感性%TNF受體相關因子6%受體,白細胞介素6%髓樣分化因子88
관절염,류풍습%다태성,단핵감산%질병역감성%TNF수체상관인자6%수체,백세포개소6%수양분화인자88
Arthritis,rheumatoid%Polymorphism,single nucleotide%Disease susceptibility%TNF receptor-associated factor 6%Receptors,interleukin-6%Myd88
目的 观察Toll样受体(TLRs)信号传导通路下游分子单核苷酸多态性与类风湿关节炎(RA)易感性的关联.方法 对350例中国北方汉族人群髓样分化因子88(Myd88)的rs7744位点,肿瘤坏死因子受体相关因子(TRAF)6的rs5030445位点,白细胞介素(IL)-6R的rs11265618、rs4845626位点进行基因分型,其中RA组162例,健康对照组188名,并对2组间各位点基因型频率及等位基因频率进行x2检验.结果 TRAF6 rs5030445、IL-6R rs11265618等位基因频率在2组之间的差异有统计学意义(x2值分别为5.716、5.704,P＜0.05),基因型频率差异均无统计学意义(P＞0.05).Myd88 rs7744、IL-6R rs4845626基因型频率、等位基因频率在2组之间的差异均无统计学意义(P＞0.05).结论 TRAF6、IL-6R单核苷酸多态性与RA易感性相关,TRAF6 rs5030445位点G等位基因可能为RA的保护性基因,IL-6Rrsl1265618位点T等位基因可能为RA易感基因.
目的 觀察Toll樣受體(TLRs)信號傳導通路下遊分子單覈苷痠多態性與類風濕關節炎(RA)易感性的關聯.方法 對350例中國北方漢族人群髓樣分化因子88(Myd88)的rs7744位點,腫瘤壞死因子受體相關因子(TRAF)6的rs5030445位點,白細胞介素(IL)-6R的rs11265618、rs4845626位點進行基因分型,其中RA組162例,健康對照組188名,併對2組間各位點基因型頻率及等位基因頻率進行x2檢驗.結果 TRAF6 rs5030445、IL-6R rs11265618等位基因頻率在2組之間的差異有統計學意義(x2值分彆為5.716、5.704,P＜0.05),基因型頻率差異均無統計學意義(P＞0.05).Myd88 rs7744、IL-6R rs4845626基因型頻率、等位基因頻率在2組之間的差異均無統計學意義(P＞0.05).結論 TRAF6、IL-6R單覈苷痠多態性與RA易感性相關,TRAF6 rs5030445位點G等位基因可能為RA的保護性基因,IL-6Rrsl1265618位點T等位基因可能為RA易感基因.
목적 관찰Toll양수체(TLRs)신호전도통로하유분자단핵감산다태성여류풍습관절염(RA)역감성적관련.방법 대350례중국북방한족인군수양분화인자88(Myd88)적rs7744위점,종류배사인자수체상관인자(TRAF)6적rs5030445위점,백세포개소(IL)-6R적rs11265618、rs4845626위점진행기인분형,기중RA조162례,건강대조조188명,병대2조간각위점기인형빈솔급등위기인빈솔진행x2검험.결과 TRAF6 rs5030445、IL-6R rs11265618등위기인빈솔재2조지간적차이유통계학의의(x2치분별위5.716、5.704,P＜0.05),기인형빈솔차이균무통계학의의(P＞0.05).Myd88 rs7744、IL-6R rs4845626기인형빈솔、등위기인빈솔재2조지간적차이균무통계학의의(P＞0.05).결론 TRAF6、IL-6R단핵감산다태성여RA역감성상관,TRAF6 rs5030445위점G등위기인가능위RA적보호성기인,IL-6Rrsl1265618위점T등위기인가능위RA역감기인.
Objective To study the correlation between single nucleotide polymorphism (SNP) of downstream mononucleotide in signal transduction of Toll-like receptors and predisposing genes of rheumatoid arthritis (RA).Methods One hundred and sixty-two RA patients were selected from northern part of Han people in China,and 188 healthy subjects were enrolled as normal controls.Rs7744 of Myd88,rs5030445 of TRAF6,rs11265618 and rs4845626 of IL-6R were analyzed.The data of genotypic frequency and allele genotypic frequency were statistical analyzed by x2 test between the two groups.Results The difference of allele frequency of TRAF6 rs5030445 between the two groups were remarkable (x2=5.716,P＜0.05),and so did the IL-6R rs11265618 (x2=5.704,P＜0.05).But the difference of genotypic frequency was not statistically significant for locus of Myd88 rs7744,TRAF6 rs5030445 and IL-6R rs11265618 (P＞0.05).And the differenceof allele frequency and genotypic frequency between the two groups had no statistical significance in locus of Myd88 rs7744 and IL-6R rs4845626 (P＞0.05).Conclusion There is significant correlation between single nucleotide polymorphism and predisposing genes of RA.The G allele of TRAF6 rs5030445 gene locus is a possible predisposing gene for RA.The T allele of IL-6R rs11265618 is a possible predisposing gene of RA.
