中华风湿病学杂志
中華風濕病學雜誌
중화풍습병학잡지
CHINESE JOURNAL OF RHEUMATOLOGY
2013年
12期
796-799,后插1
,共5页
张思功%田小兰%张寅丽%杨阚波%周航%王国春%卢昕
張思功%田小蘭%張寅麗%楊闞波%週航%王國春%盧昕
장사공%전소란%장인려%양감파%주항%왕국춘%로흔
皮肌炎%肺疾病,间质性%中心粒细胞胞外网状陷阱
皮肌炎%肺疾病,間質性%中心粒細胞胞外網狀陷阱
피기염%폐질병,간질성%중심립세포포외망상함정
Dermatomyositis%Lung disease,interstitial%Neutrophil extracellular traps
目的 探讨中性粒细胞胞外网状陷阱(NETs)与皮肌炎患者间质性肺病(ILD)发生的关联性.方法 研究纳入36例皮肌炎患者,其中19例伴发ILD.同时选择47名健康成年人作为健康对照组.比较2组血浆诱发NETs形成和降解NETs的能力.结果 皮肌炎患者的血浆较健康对照组的血浆能诱发更多的正常中性粒细胞形成NETs[(246±93) RFUs和(192±53) RFUs,p=0.002].皮肌炎患者的血浆对NETs的降解显著低于健康对照,而且与不伴ILD的皮肌炎患者相比,伴发ILD的皮肌炎患者降低更明显[(83±13)％和(59±21)％,P＜0.01].进一步分析皮肌炎伴发ILD的亚组发现,4例伴发亚急性ILD的患者对NETs的降解显著低于慢性或无症状ILD的皮肌炎患者[(36±14)％和(65％±19)％,P=0.0139].结论 皮肌炎患者的血浆诱发NETs形成显著增加,伴发ILD的皮肌炎患者不能完全降解形成的NETs;提示NETs的清除异常在皮肌炎及皮肌炎伴发的ILD中起一定作用.
目的 探討中性粒細胞胞外網狀陷阱(NETs)與皮肌炎患者間質性肺病(ILD)髮生的關聯性.方法 研究納入36例皮肌炎患者,其中19例伴髮ILD.同時選擇47名健康成年人作為健康對照組.比較2組血漿誘髮NETs形成和降解NETs的能力.結果 皮肌炎患者的血漿較健康對照組的血漿能誘髮更多的正常中性粒細胞形成NETs[(246±93) RFUs和(192±53) RFUs,p=0.002].皮肌炎患者的血漿對NETs的降解顯著低于健康對照,而且與不伴ILD的皮肌炎患者相比,伴髮ILD的皮肌炎患者降低更明顯[(83±13)％和(59±21)％,P＜0.01].進一步分析皮肌炎伴髮ILD的亞組髮現,4例伴髮亞急性ILD的患者對NETs的降解顯著低于慢性或無癥狀ILD的皮肌炎患者[(36±14)％和(65％±19)％,P=0.0139].結論 皮肌炎患者的血漿誘髮NETs形成顯著增加,伴髮ILD的皮肌炎患者不能完全降解形成的NETs;提示NETs的清除異常在皮肌炎及皮肌炎伴髮的ILD中起一定作用.
목적 탐토중성립세포포외망상함정(NETs)여피기염환자간질성폐병(ILD)발생적관련성.방법 연구납입36례피기염환자,기중19례반발ILD.동시선택47명건강성년인작위건강대조조.비교2조혈장유발NETs형성화강해NETs적능력.결과 피기염환자적혈장교건강대조조적혈장능유발경다적정상중성립세포형성NETs[(246±93) RFUs화(192±53) RFUs,p=0.002].피기염환자적혈장대NETs적강해현저저우건강대조,이차여불반ILD적피기염환자상비,반발ILD적피기염환자강저경명현[(83±13)％화(59±21)％,P＜0.01].진일보분석피기염반발ILD적아조발현,4례반발아급성ILD적환자대NETs적강해현저저우만성혹무증상ILD적피기염환자[(36±14)％화(65％±19)％,P=0.0139].결론 피기염환자적혈장유발NETs형성현저증가,반발ILD적피기염환자불능완전강해형성적NETs;제시NETs적청제이상재피기염급피기염반발적ILD중기일정작용.
Objective This study was focused on the association between neutrophil extracellular traps (NETs) and interstitial lung disease (ILD) in patients with dermatomyositis (DM).Methods Thirty six patients who satisfied the Bohan & Peter criteria for DM were recruited to this study,among whom 19 were complicated with ILD.Forty seven age and sex matched healthy Chinese volunteers were selected to be control subjects.The plasma samples of these patients were tested for the formation and degradation of NETs.Results DM plasma induced more NETs formation than control plasma did [(246±93) RFUs vs (192±53) RFUs,P=0.002].Compared to control,DM plasma exhibited a signficantry decreased ability to degrade NETs.Further mere,compared with DM patients without ILD (DMNL),DM patients with ILD (DML) could not degrade NETs completely [(83±13)％ vs (59±21)％,P＜0.01].All four DM patients with subacute ILD exhibited a significantly lower ability to degrade NETs than patients with chronic or asymptomatic ILD [(36±14)％ vs (65±19)％,P=0.0139].Conclusion These data show that more NETs formation is induced by plasma and DML fails to completely degrade NETs.These suggest that NETs may play a role in the pathogenesis of DM and DM-associated ILD.
