CAJ | 학술논문

目的将疾病专属量表与普适性量表相结合应用于SLE患者生活质量的评估.方法采用SLE专属的生活质量量表(SLEQOL)及健康调查简表(SF-36)对SLE患者进行问卷调查,记录基本信息.检测补体等血浆生物学指标.采用方差分析、相关分析及多元线性回归模型等进行统计分析.结果 SLEQOL躯体功能以及SF-36健康变化均与SLEDAI积分呈正相关(r值分别为:0.36,0.19;P＜0.05);而SF-36中生理机能、生理职能、情感职能、躯体疼痛及精力5个维度均与SLEDAI积分呈负相关(r值分别为:-0.20,-0.19,-0.19,-0.19,-0.21;P＜0.05).重度活动组与病情无活动组及轻、中度活动组比较,SLEQOL躯体功能维度积分明显升高(18±10和11±5,12±6,13±7; P＜0.05);与病情轻度活动组比较,中、重度活动组SF-36健康变化积分明显降低(23±28,14±17和34±39,P＜0.05);与病情无活动组相比,轻度与重度活动组SF-36情感职能方面积分明显降低(30±41,34±39和44±44,P＜0.05);病程和学历是影响SIEQOL评分的因素.结论 SLE患者生活质量与疾病活动度有关,且病程及学历可能是影响患者生活质量的主要因素.
목적 장질병전속량표여보괄성량표상결합응용우SLE환자생활질량적평고.방법 채용SLE전속적생활질량량표(SLEQOL)급건강조사간표(SF-36)대SLE환자진행문권조사,기록기본신식.검측보체등혈장생물학지표.채용방차분석、상관분석급다원선성회귀모형등진행통계분석.결과 SLEQOL구체공능이급SF-36건강변화균여SLEDAI적분정정상관(r치분별위:0.36,0.19;P＜0.05);이SF-36중생리궤능、생리직능、정감직능、구체동통급정력5개유도균여SLEDAI적분정부상관(r치분별위:-0.20,-0.19,-0.19,-0.19,-0.21;P＜0.05).중도활동조여병정무활동조급경、중도활동조비교,SLEQOL구체공능유도적분명현승고(18±10화11±5,12±6,13±7; P＜0.05);여병정경도활동조비교,중、중도활동조SF-36건강변화적분명현강저(23±28,14±17화34±39,P＜0.05);여병정무활동조상비,경도여중도활동조SF-36정감직능방면적분명현강저(30±41,34±39화44±44,P＜0.05);병정화학력시영향SIEQOL평분적인소.결론 SLE환자생활질량여질병활동도유관,차병정급학력가능시영향환자생활질량적주요인소.
Objective To elucidate the relationship between quality of life (QOL) and disease activity of systemic lupus erythematosus (SLE),as well as to reveal the factors impacting disease activity and the QOL of SLE utilizing the combination of SLE-specific quality of life questionnaire (SLEQOL) and the medical outcomes survey short form 36 (SF-36).Methods SLEQOL and SF-36 health survey questionnaire were applied.Information on gender,disease duration,age,education level were collected.Serum complement (C3 and C4) level and erythrocyte sedimentation rate (ESR) were measured.Patients were divided into inactive,mild active,moderate active and severe active respectively according to SLE disease activity index (SLEDAI).Pearson's product moment correlation coefficient was used to analyze the correlation between the activity of disease and the QOL.Multiple linear regression was employed to explore the factors which could impact on SLEQOL.Results The physical function of SLEQOL was positively correlated with SLEDAI (r=0.36; P＜0.05).The association between reported health transition of SF-36 and SLEDAI was positive (r=0.19; P＜0.05).Physical functioning,role-physical,role-emotional,body pain and vitality were all negatively correlated with SLEDAI (r:-0.20,-0.19,-0.19,-0.19,-0.21 respectively; P＜0.05).The scores of patients with severe disease activity were significantly increased in the physical functioning of SLEQOL than other three groups (18±10 vs 11±5,12±6,13±7; P＜0.05).Scores on the Health transition of patients with moderate and severe disease activity were lower than those of whom with mild disease activity (23±28.14±17 vs 34±39,P＜0.05).Patients with mild or severe disease activity had lower score than those of patieuts in disease inactive (30±41,34±39 vs 44±44,P＜0.05).Multiple linear regression analyses showed that disease duration and education level might be the influencing factors of SLEQOL.Conclusion QOL of patients with SLE is related to the level of disease activity and is impacted by disease duration and education.