CAJ | 학술논문

目的研究基于CRP和ESR计算RA患者DAS28在评价患者疾病活动度方面的差别.方法入选222例RA患者,记录患者的性别、年龄、病史、肿胀关节数、压痛关节数、CRP、ESR、视觉模拟评分.分别计算DAS28-ESR和DAS28-CRP.统计学方法采用t检验、Pearson相关分析.结果 DAS28-ESR和DAS28-CRP具有良好的线性相关关系(r=0.968,P＜0.05).DAS28-CRP的分布(3.3±1.7)较DAS28-ESR的分布(3.9±1.8)偏左侧,差异有统计学意义(P＜0.05).女性患者DAS28-CRP和DAS28-ESR的差异(0.59±0.43)较男性患者(0.24±0.45)更大,差异有统计学意义(P＜0.05).DAS28-CRP和DAS28-ESR之间的差异与病史、年龄均无相关性(P＞0.05).结论 DAS28-CRP和DAS28-ESR在评价RA患者疾病活动度、制定达标治疗方案时存在差异,值得重视.
목적 연구기우CRP화ESR계산RA환자DAS28재평개환자질병활동도방면적차별.방법 입선222례RA환자,기록환자적성별、년령、병사、종창관절수、압통관절수、CRP、ESR、시각모의평분.분별계산DAS28-ESR화DAS28-CRP.통계학방법채용t검험、Pearson상관분석.결과 DAS28-ESR화DAS28-CRP구유량호적선성상관관계(r=0.968,P＜0.05).DAS28-CRP적분포(3.3±1.7)교DAS28-ESR적분포(3.9±1.8)편좌측,차이유통계학의의(P＜0.05).녀성환자DAS28-CRP화DAS28-ESR적차이(0.59±0.43)교남성환자(0.24±0.45)경대,차이유통계학의의(P＜0.05).DAS28-CRP화DAS28-ESR지간적차이여병사、년령균무상관성(P＞0.05).결론 DAS28-CRP화DAS28-ESR재평개RA환자질병활동도、제정체표치료방안시존재차이,치득중시.
Objective To compare the disease activity score (DSA) 28-CRP and DAS28-ESR in patients with rheumatoid arthritis.Methods Two hundred and twenty-two patients were enrolled,and their sex,age,disease duration,swollen joint count,tender joint count,CRP,ESR,visual analogue scale were recorded.DAS28-ESR and DAS28-CRP were calculated and then analyzed by t test and Pearson's correlation test.Results There was a significant linear correlation between DAS28-ESR and DAS28-CRP (P＜0.05),with correlation coefficient of 0.968.Both DAS28-CRP (3.3±1.7) and DAS28-ESR (3.9±1.8) scores presented with normal distribution (P＞0.05),with the peak of the DAS28-CRP left to that of the DAS28-ESR.There was statistically significant difference between these two (P＜0.05).The difference between DAS28-CRP and DAS28-ESR was much higher in female (0.59±0.43) than in male (0.24±0.45,P＜0.05).The difference between DAS28-CRP and DAS28-ESR was not related to age and disease duration.Conclusion Attention should be paid to the assessment score when making the plan of "treating to target" since there is difference between DAS-28-ESR and DAS-28-CRP.