中华风湿病学杂志
中華風濕病學雜誌
중화풍습병학잡지
CHINESE JOURNAL OF RHEUMATOLOGY
2014年
7期
482-485
,共4页
冯秀媛%常志芳%庞春艳%王永福
馮秀媛%常誌芳%龐春豔%王永福
풍수원%상지방%방춘염%왕영복
红斑狼疮,系统性%高脂血症
紅斑狼瘡,繫統性%高脂血癥
홍반랑창,계통성%고지혈증
Lupus erythematosus,systemic%Hyperlipidemia
目的 探讨血脂异常在SLE患者中的临床意义.方法 采用独立样本t检验比较326例SLE患者及300名健康对照组血脂水平,并分别比较SLE患者各亚组之间的血脂水平;采用Pearson及Spearman相关性分析分别对SLE患者的血脂水平与其临床表现及实验室检查指标的相关性进行分析.结果 ①SLE患者血清TC[(3.8±1.5)mmol/L]、TG[(2.1±1.6)mmol/L]及LDL-C[(2.1±0.9)mmol/L]均明显高于对照组[(3.4±0.6),(0.8±0.4),(1.9±0.5) mmol/L],而HDL-C[(1.2±0.9)mmol/L]明显低于对照组[(2.0±0.5) mmol/L],差异均具有统计学意义(t=4.953,P=0.000;t=14.569,P=0.000;t=3.204,P=0.001;t=-14.335,P=0.000).②LN组血清TC[(4.0±1.7)mmol/L]、TG[(2.5±1.7)mmol/L]及LDL-C[(2.2±1.0)mmol/L]水平均明显高于非LN组[(3.6±1.0),(1.6±1.0),(1.9±0.7) mmol/L],差异均具有统计学意义(t=2.646,P=0.009;t=6.292,P=0.000;t=3.261,P=0.001).③低补体血症组与补体正常组血脂水平相比,TG[(2.2±1.6)和(1.8±1.4) mmol/L]明显增高,而HDL-C[(1.1±0.4)和(1.6±1.7) mmol/L]明显降低,差异有统计学意义(t=2.098,P=0.038;t=-2.375,P=0.020).④抗dsDNA抗体阳性组与抗dsDNA抗体阴性组血脂水平比较,TG[(2.3±1.7)和(2.0±1.4) mmol/L]明显增高,而HDL-C[(1.5±0.4)和(1.4±1.2) mmol/L]明显降低,差异有统计学意义(t=1.989,P=0.048; t=-2.979,P=0.003).⑤SLE患者血脂水平与其部分临床表现及实验室指标具有相关性.结论 SLE患者脂质代谢存在明显异常,并与LN、低补体血症及抗dsDNA抗体密切相关.
目的 探討血脂異常在SLE患者中的臨床意義.方法 採用獨立樣本t檢驗比較326例SLE患者及300名健康對照組血脂水平,併分彆比較SLE患者各亞組之間的血脂水平;採用Pearson及Spearman相關性分析分彆對SLE患者的血脂水平與其臨床錶現及實驗室檢查指標的相關性進行分析.結果 ①SLE患者血清TC[(3.8±1.5)mmol/L]、TG[(2.1±1.6)mmol/L]及LDL-C[(2.1±0.9)mmol/L]均明顯高于對照組[(3.4±0.6),(0.8±0.4),(1.9±0.5) mmol/L],而HDL-C[(1.2±0.9)mmol/L]明顯低于對照組[(2.0±0.5) mmol/L],差異均具有統計學意義(t=4.953,P=0.000;t=14.569,P=0.000;t=3.204,P=0.001;t=-14.335,P=0.000).②LN組血清TC[(4.0±1.7)mmol/L]、TG[(2.5±1.7)mmol/L]及LDL-C[(2.2±1.0)mmol/L]水平均明顯高于非LN組[(3.6±1.0),(1.6±1.0),(1.9±0.7) mmol/L],差異均具有統計學意義(t=2.646,P=0.009;t=6.292,P=0.000;t=3.261,P=0.001).③低補體血癥組與補體正常組血脂水平相比,TG[(2.2±1.6)和(1.8±1.4) mmol/L]明顯增高,而HDL-C[(1.1±0.4)和(1.6±1.7) mmol/L]明顯降低,差異有統計學意義(t=2.098,P=0.038;t=-2.375,P=0.020).④抗dsDNA抗體暘性組與抗dsDNA抗體陰性組血脂水平比較,TG[(2.3±1.7)和(2.0±1.4) mmol/L]明顯增高,而HDL-C[(1.5±0.4)和(1.4±1.2) mmol/L]明顯降低,差異有統計學意義(t=1.989,P=0.048; t=-2.979,P=0.003).⑤SLE患者血脂水平與其部分臨床錶現及實驗室指標具有相關性.結論 SLE患者脂質代謝存在明顯異常,併與LN、低補體血癥及抗dsDNA抗體密切相關.
목적 탐토혈지이상재SLE환자중적림상의의.방법 채용독립양본t검험비교326례SLE환자급300명건강대조조혈지수평,병분별비교SLE환자각아조지간적혈지수평;채용Pearson급Spearman상관성분석분별대SLE환자적혈지수평여기림상표현급실험실검사지표적상관성진행분석.결과 ①SLE환자혈청TC[(3.8±1.5)mmol/L]、TG[(2.1±1.6)mmol/L]급LDL-C[(2.1±0.9)mmol/L]균명현고우대조조[(3.4±0.6),(0.8±0.4),(1.9±0.5) mmol/L],이HDL-C[(1.2±0.9)mmol/L]명현저우대조조[(2.0±0.5) mmol/L],차이균구유통계학의의(t=4.953,P=0.000;t=14.569,P=0.000;t=3.204,P=0.001;t=-14.335,P=0.000).②LN조혈청TC[(4.0±1.7)mmol/L]、TG[(2.5±1.7)mmol/L]급LDL-C[(2.2±1.0)mmol/L]수평균명현고우비LN조[(3.6±1.0),(1.6±1.0),(1.9±0.7) mmol/L],차이균구유통계학의의(t=2.646,P=0.009;t=6.292,P=0.000;t=3.261,P=0.001).③저보체혈증조여보체정상조혈지수평상비,TG[(2.2±1.6)화(1.8±1.4) mmol/L]명현증고,이HDL-C[(1.1±0.4)화(1.6±1.7) mmol/L]명현강저,차이유통계학의의(t=2.098,P=0.038;t=-2.375,P=0.020).④항dsDNA항체양성조여항dsDNA항체음성조혈지수평비교,TG[(2.3±1.7)화(2.0±1.4) mmol/L]명현증고,이HDL-C[(1.5±0.4)화(1.4±1.2) mmol/L]명현강저,차이유통계학의의(t=1.989,P=0.048; t=-2.979,P=0.003).⑤SLE환자혈지수평여기부분림상표현급실험실지표구유상관성.결론 SLE환자지질대사존재명현이상,병여LN、저보체혈증급항dsDNA항체밀절상관.
Objective To explore the clinical significance of dyslipidemia in patients with systemic lupus erythematosus (SLE).Methods By independent-samples t test,serum lipid level was compared between 326 SLE patients and 300 healthy controls.The total cholesterol (TC),triglyceride (TG),lowdensity lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) levels were partially compared in subgroups of SLE patients.The correlation of serum TC,TG,LDL-C and HDL-C with clinical manifestations and laboratory findings in SLE was analyzed by Pearson or Spearman correlation analysis.Results ①The serum levels of TC [(3.8±1.5) mmol/L],TG [(2.1±1.6) mmol/L] and LDL-C [(2.1±0.9) mmol/L] were significantly higher in SLE group than those of the control group [(3.4±0.6),(0.8±0.4),(1.9± 0.5) mmol/L],and the serum level of HDL-C [(1.2±0.9) mmol/L] was significantly lower in SLE group than that of the control group [(2.0±0.5) mmolFL] (t=4.953,P=0.000; t=14.569,P=0.000; t=3.204,P=0.001; t=-14.335,P=0.000].② The serum levels of TC [(4.0± 1.7) mmol/L],TG [(2.5± 1.7) mmol/L] and LDL-C [(2.2±1.0) mmol/L] were significantly higher in LN group than those of the non-LN group [(3.6±1.0),(1.6± 1.0),(1.9±0.7) mmol/L; t=2.646,P=0.009; t=6.292,P=0.000; t=3.261,P=0.001].③ The serum level of TG [(2.2±1.6) vs (1.8±1.4) mmol/L] was significantly higher in SLE patients with hypocomplementemia than that of the normal ones (t =2.098,P=0.038).The serum level of HDL-C [(1.1 ±0.4) vs (1.6± 1.7) mmol/L] was significantly lower in SLE patients with hypocomplementemia than that of the normal ones (t=-2.375,P=0.020).④ The serum level of TG [(2.3±1.7) vs (2.0±1.4) mmol/L] was significantly higher in anti-dsDNA antibody positive patients than that of negative ones (t=1.989,P=0.048).The serum level of HDL-C [(1.5± 0.4) vs (1.4±1.2) mmol/L] was significantly lower in anti-dsDNA antibody positive patients than that of negative ones (t=-2.979,P=0.003).⑤ The lipid level was correlated with the clinical manifestations and laboratory findings in SLE patients.Conclusion Dyslipidemia exists in patients with SLE and has close correlation with LN,hypocomplementemia and positive anti-dsDNA antibody.
