CAJ | 학술논문

目的探讨性别、年龄因素对成人正常胰腺ADC值的影响.方法回顾性分析383例行上腹部MRI检查,实验室和MRI检查显示胰腺正常的患者资料,男290例,年龄21～ 78岁；女93例,年龄22 ～ 78岁.患者行DWI检查,分别测量胰腺头、颈、体尾的ADC值,并计算每个患者的平均ADC值.采用独立样本t检验与Mann-Whitney U检验分别分析不同性别、年龄患者胰腺ADC值的差异；Spearman秩相关分析研究胰腺ADC值与年龄的相关性；Kruskal-Wallis H检验评估不同年龄段平均ADC之间的差异.结果 290例男性患者的平均年龄为(52±10)岁,胰腺ADC值中位数为1.57×10-3mm2/s(上下四分位间距为1.41×10-3 ～ 1.74×10-3)mm2/s;93例女性患者平均年龄为(51±11)岁,胰腺ADC值中位数为1.60×10-3mm2/s(上下四分位间距为1.47×10-3～1.77×10-3)mm2/s,男女患者年龄差异无统计学意义(t值=0.267,P值=0.790),胰腺平均ADC值差异也无统计学意义(Z值=1.335,P值=0.182).383例正常胰腺ADC值与年龄无相关性(r值=0.016,P值=0.752).≤40岁、41 ～50岁、51 ～ 60岁和＞60岁患者分别为56、108、139和80例,胰腺ADC值中位数分别为1.58×10-3、1.54 ×10-3、1.59×10-3和1.57×10-3 mm2/s,差异无统计学意义(x2值=2.15,P值=0.542).结论成人正常胰腺平均ADC值与年龄、性别无明显相关性.
목적 탐토성별、년령인소대성인정상이선ADC치적영향.방법 회고성분석383례행상복부MRI검사,실험실화MRI검사현시이선정상적환자자료,남290례,년령21～ 78세；녀93례,년령22 ～ 78세.환자행DWI검사,분별측량이선두、경、체미적ADC치,병계산매개환자적평균ADC치.채용독립양본t검험여Mann-Whitney U검험분별분석불동성별、년령환자이선ADC치적차이；Spearman질상관분석연구이선ADC치여년령적상관성；Kruskal-Wallis H검험평고불동년령단평균ADC지간적차이.결과 290례남성환자적평균년령위(52±10)세,이선ADC치중위수위1.57×10-3mm2/s(상하사분위간거위1.41×10-3 ～ 1.74×10-3)mm2/s;93례녀성환자평균년령위(51±11)세,이선ADC치중위수위1.60×10-3mm2/s(상하사분위간거위1.47×10-3～1.77×10-3)mm2/s,남녀환자년령차이무통계학의의(t치=0.267,P치=0.790),이선평균ADC치차이야무통계학의의(Z치=1.335,P치=0.182).383례정상이선ADC치여년령무상관성(r치=0.016,P치=0.752).≤40세、41 ～50세、51 ～ 60세화＞60세환자분별위56、108、139화80례,이선ADC치중위수분별위1.58×10-3、1.54 ×10-3、1.59×10-3화1.57×10-3 mm2/s,차이무통계학의의(x2치=2.15,P치=0.542).결론 성인정상이선평균ADC치여년령、성별무명현상관성.
Objective To investigate the effect of gender and age on the apparent diffusion coefficient (ADC) of normal adult pancreas.Methods A total of 383 patients with normal pancreas (290 male,93 female,range from 21 to 78 years of age) were enrolled in this study.The subjects were divided into four groups based on different age (≤40 years,41-50 years,51-60 years and ＞60 years) with patient number of 56,108,139 and 80,respectively.Breath-hold single-shot echo-planar DWI (b value =0,500 s/mm2) was performed to determine ADCs on all patients.The average ADCs was calculated by four ADCs measured from the head to tail part of the pancreas in each patient.Patients with different age or gender were analyzed by independent-samples t test.Effect of gender on ADCs was analyzed using the Mann-Whitney U test.Relationship between ADCs and age was analyzed using Spearman rank-order correlation test,and Kruskal-Wallis H test was used to compare the ADCs among 4 age groups.Results The median pancreatic ADC values in female group(n =93) [1.60 × 10-3 mm2/s (1.47 × 10-3-1.77 × 10-3) mm2/s] was higher than that in male group (n =290) [1.57 × 10-3mm2/s(1.41 × 10-3-1.74 × 10-3)mm2/s].Mann-Whitney U test results showed the mean ADCs was similar between the two groups (Z =1.335,P =0.182).The age distribution was similar between the male [(52 ± 10) years of age] and female [(51 ± 11) years of age]groups (t =0.267,P=0.790).The age spectrum showed that there was no correlation between the average ADC values and age (r =0.016,P =0.752).The median ADC values of the four age groups were 1.58 ×10-3,1.54 × 10-3,1.59 × 10-3 and 1.57 × 10-3 mm2/s,respectively.Kruskal-Wallis H test showed no significant difference of mean ADCs among the age groups (x2 =2.15,P =0.542).Conclusion There is no correlation of ADCs between age and gender in normal adult pancreas.