CAJ | 학술논문

目的探讨采用CT能谱成像测量体模骨密度的精密度及准确度.方法体模采用编号145欧洲腰椎体模,包含3个松质骨密度不等的椎体,由上至下分别记为L1、L2、L3,3个椎体的松质骨羟基磷灰石(HAP)含量分别为50、100和200 mg/cm3.对上述体模行能谱CT成像,相同条件下重复扫描10次,基物质对为HAP-水和HAP-脂肪.测量HAP含量,并计算相对标准偏差(RSD)和测量相对误差(RE).HAP含量能谱CT检查测量值同实际值的比较采用单样本t检验,各椎体在不同基物质对下测量值的比较采用配对t检验.结果采用HAP-水基物质对时,测得L1、L2和L3的HAP含量分别为(54.5±4.2)、(113.3±2.7)和(219.7±7.7) mg/cm3,与实际值(分别为50.0、100.0和200.0 mg/cm3)的差异均有统计学意义(t值分别为3.400、15.874和8.155,P均＜0.01);RSD分别为7.67％、2.34％和3.48％;RE分别为5.3％、12.9％和9.8％.采用HAP-脂肪基物质对时,测得L1、L2和L3的HAP含量分别为(91.9±4.0)、(149.5±2.5)和(254.2±7.2) mg/cm3,与实际值的差异均有统计学意义(t值分别为33.498、62.399和23.578,P值均＜0.01);RSD分别为4.31％、1.68％和2.86％;RE分别为81.0％、49.1％和27.0％.各椎体采用HAP-脂肪基物质测得值高于HAP-水基物质值,差异均有统计学意义(P均＜0.01).结论应用CT能谱成像测量骨密度的精密度与准确度均较差,尚不适用于临床应用.
목적 탐토채용CT능보성상측량체모골밀도적정밀도급준학도.방법 체모채용편호145구주요추체모,포함3개송질골밀도불등적추체,유상지하분별기위L1、L2、L3,3개추체적송질골간기린회석(HAP)함량분별위50、100화200 mg/cm3.대상술체모행능보CT성상,상동조건하중복소묘10차,기물질대위HAP-수화HAP-지방.측량HAP함량,병계산상대표준편차(RSD)화측량상대오차(RE).HAP함량능보CT검사측량치동실제치적비교채용단양본t검험,각추체재불동기물질대하측량치적비교채용배대t검험.결과 채용HAP-수기물질대시,측득L1、L2화L3적HAP함량분별위(54.5±4.2)、(113.3±2.7)화(219.7±7.7) mg/cm3,여실제치(분별위50.0、100.0화200.0 mg/cm3)적차이균유통계학의의(t치분별위3.400、15.874화8.155,P균＜0.01);RSD분별위7.67％、2.34％화3.48％;RE분별위5.3％、12.9％화9.8％.채용HAP-지방기물질대시,측득L1、L2화L3적HAP함량분별위(91.9±4.0)、(149.5±2.5)화(254.2±7.2) mg/cm3,여실제치적차이균유통계학의의(t치분별위33.498、62.399화23.578,P치균＜0.01);RSD분별위4.31％、1.68％화2.86％;RE분별위81.0％、49.1％화27.0％.각추체채용HAP-지방기물질측득치고우HAP-수기물질치,차이균유통계학의의(P균＜0.01).결론 응용CT능보성상측량골밀도적정밀도여준학도균교차,상불괄용우림상응용.
Objective To assess the precision and accuracy of bone mineral measurement utilizing spectral CT imaging with a European Spine Phantom (ESP).Methods Within the ESP named Num.145,there are three orderly vertebral bodies which were marked by L1 with Hydroxyapatite(HAP)of 50.0 mg/cm3,L2 with HAP of 100.0 mg/cm3,and L3 with HAP of 200.0 mg/cm3.The ESP was scanned by using gemstone spectral imaging (GSI) model ten times.Using GSI viewer,measurements of HAP-water concentration and HAP-fat concentration were done.The precision and accuracy of each parameter were evaluated by the results of relative standard deviation (RSD) and relative error (RE),respectively.The difference between each parameter with the real value was evaluated statistically by one-sample t test.The differences among the three vertebral bodies' same parameter were evaluated statistically by paired t test.Results The results of HAP-water concentration in L1,L2,L3 were (54.5 ±4.2),(113.3 ± 2.7) and (219.7 ± 7.7) mg/cm3,each of which was significantly higher than the real value(t values were 3.400,15.874 and 8.155,P＜0.01).And,the RSD values were 7.67％,2.34％ and 3.48％;the RE values were 5.3％,12.9％ and 9.8％.The results of HAP-fat concentration in L1,L2,L3 were (91.9±4.0),(149.5±2.5) and (254.2±7.2) mg/cm3,each of which was significantly higher than the real value(t values were 33.489,62.399 and 23.578,P＜0.01).And the RSD values were 4.31％,1.68％ and 2.86％; the RE values were 81.0％,49.1％ and 27.0％.In every vertebral body,the result of HAP-water concentration was significantly lower than the result of HAP-fat concentration (P＜0.01).Conclusions By utilizing spectral CT imaging,the precision and accuracy of bone mineral measurement were poor.Therefore,this method is not applicable for clinical measurement.