CAJ | 학술논문

目的探讨采用CT灌注成像评价实验用小型猪肾脏经皮纳米刀消融后急性期肾血流灌注的变化.方法实验用巴马小型猪6头,按抽签法随机将每头猪两侧肾分成实验组和正常对照组.实验组采用CT导向下经皮穿刺技术,将纳米刀消融探针置入肾实质内行不可逆电穿孔消融,对照组不采取任何治疗措施.消融结束后立即行双侧肾脏CT灌注成像,分别计算2组的肾血流灌注参数,包括主动脉达峰时间(ATTP)及峰值(PAE),肾实质血流量(BF)、血容量(BV)、最大增强值(PE)和达峰时间(TTP),并采用配对t检验进行比较.结果 6头小型猪均穿刺并消融成功.ATTP为(24.33±1.63)s,PAE为(440.00±41.95)HU.对照组BF、BV、PE和TTP分别为(66.46± 15.32)ml· 100 ml-·min-1、(75.91±40.70) ml/100 g、(101.21±51.34)HU和(35.84± 19.04)s,实验组分别为(12.16±6.80)ml·100 ml-1·min-、(19.93± 17.54) ml/100 g、(24.33± 15.51) HU和(61.12±26.74)s,差异均有统计学意义(t值分别为6.40、3.03、3.52和4.63,P均＜0.05).结论实验猪肾脏经纳米刀消融术后,急性期消融区肾脏血流灌注降低.
목적 탐토채용CT관주성상평개실험용소형저신장경피납미도소융후급성기신혈류관주적변화.방법 실험용파마소형저6두,안추첨법수궤장매두저량측신분성실험조화정상대조조.실험조채용CT도향하경피천자기술,장납미도소융탐침치입신실질내행불가역전천공소융,대조조불채취임하치료조시.소융결속후립즉행쌍측신장CT관주성상,분별계산2조적신혈류관주삼수,포괄주동맥체봉시간(ATTP)급봉치(PAE),신실질혈류량(BF)、혈용량(BV)、최대증강치(PE)화체봉시간(TTP),병채용배대t검험진행비교.결과 6두소형저균천자병소융성공.ATTP위(24.33±1.63)s,PAE위(440.00±41.95)HU.대조조BF、BV、PE화TTP분별위(66.46± 15.32)ml· 100 ml-·min-1、(75.91±40.70) ml/100 g、(101.21±51.34)HU화(35.84± 19.04)s,실험조분별위(12.16±6.80)ml·100 ml-1·min-、(19.93± 17.54) ml/100 g、(24.33± 15.51) HU화(61.12±26.74)s,차이균유통계학의의(t치분별위6.40、3.03、3.52화4.63,P균＜0.05).결론 실험저신장경납미도소융술후,급성기소융구신장혈류관주강저.
Objective To investigate quantitative changes of renal perfusion in acute phase with CT perfusion imaging after percutaneous nanoknife ablation in experimental miniature pig kedneys.Methods Six Bama miniature pigs were were randomly divided into experimental group and control group.Nanoknife ablation probe was placed into renal parenchyma in experimental groups by means of CT-guided percutaneous irreversible electroporation.Control groups did not receive any treatment measures.Bilateral renal CT perfusion imaging were carried out immediately after ablation.Renal perfusion parameters of two groups were calculated respectively,including aortic time to peak (ATTP) and peak aortic enhancement (PAE),blood flow (BF),blood volume (BV),peak enhancement (PE),time to peak (TTP),and were compared using a paired t test.Results Six miniature pigs were punctured and ablated successfully.Mean ATFP was (24.33±1.63) s.Mean PAE was (440.00±41.95) HU.BF,BV,PE and TTP of control groups were (66.46± 15.32) ml· 100 ml-1· min-1,(75.91±40.70) ml/100 g,(101.21±51.34) HU and (35.84-± 19.04) s respectively and those of the experimental groups were (12.16±6.80) ml· 100 ml-1· min-1,(19.93±17.54) ml/100 g,(24.33± 15.51) HU and (61.12± 26.74) s respectively.The differences were statistically significant (t values were 6.40,3.03,3.52 and 4.63,respectively,P＜0.05).Conclusion Renal perfusion parameters in acute phase are reduced after nanoknife ablation in experimental miniature pigs.