中华放射医学与防护杂志
中華放射醫學與防護雜誌
중화방사의학여방호잡지
Chinese Journal of Radiological Medicine and Protection
2009年
5期
495-498
,共4页
子宫内膜癌/放射治疗%调强放射治疗%射线能量%正常组织%积分剂量
子宮內膜癌/放射治療%調彊放射治療%射線能量%正常組織%積分劑量
자궁내막암/방사치료%조강방사치료%사선능량%정상조직%적분제량
Endometrial cancer/radiotherapy%Intensity-modulated radiation therapy%Beam energy%Normal tissue%Integral dose
目的 研究射线能量对子宫内膜癌术后全盆腔调强放射治疗计划质量的影响.方法 选择10例子宫内膜癌术后患者,对每例患者分别设计6和18 MV的全盆腔调强放射治疗计划.所有计划均使用相同的布野方案和剂量体积约束.比较两组计划的靶区、危及器官和正常组织的剂量分布.结果 6和18 MV计划的平均PTV100分别是95.6%和95.3%(检验值P=0.26),Dmean分别是52.55 Gy和52.60 Gy(P=0.54),适形指数分别是0.87和0.88(P=0.03),均匀性指数均为1.10(P=0.38).18 MV计划较6 MV计划正常组织的平均积分剂量下降了2.4%(P=0.001),小肠和结肠的平均V30和V50分别下降了4.2%(P=0.006)和3.3%(P=0.046),其他危及器官的剂量分布间差异无统计学意义.结论 对于子宫内膜癌的术后全盆腔调强放射治疗,18 MV计划比6 MV计划剂量分布的适形度更好,能够更好地保护正常组织、小肠和结肠.两组计划靶区的覆盖度和剂量分布的均匀性,以及直肠、膀胱和盆腔骨的保护相当.
目的 研究射線能量對子宮內膜癌術後全盆腔調彊放射治療計劃質量的影響.方法 選擇10例子宮內膜癌術後患者,對每例患者分彆設計6和18 MV的全盆腔調彊放射治療計劃.所有計劃均使用相同的佈野方案和劑量體積約束.比較兩組計劃的靶區、危及器官和正常組織的劑量分佈.結果 6和18 MV計劃的平均PTV100分彆是95.6%和95.3%(檢驗值P=0.26),Dmean分彆是52.55 Gy和52.60 Gy(P=0.54),適形指數分彆是0.87和0.88(P=0.03),均勻性指數均為1.10(P=0.38).18 MV計劃較6 MV計劃正常組織的平均積分劑量下降瞭2.4%(P=0.001),小腸和結腸的平均V30和V50分彆下降瞭4.2%(P=0.006)和3.3%(P=0.046),其他危及器官的劑量分佈間差異無統計學意義.結論 對于子宮內膜癌的術後全盆腔調彊放射治療,18 MV計劃比6 MV計劃劑量分佈的適形度更好,能夠更好地保護正常組織、小腸和結腸.兩組計劃靶區的覆蓋度和劑量分佈的均勻性,以及直腸、膀胱和盆腔骨的保護相噹.
목적 연구사선능량대자궁내막암술후전분강조강방사치료계화질량적영향.방법 선택10례자궁내막암술후환자,대매례환자분별설계6화18 MV적전분강조강방사치료계화.소유계화균사용상동적포야방안화제량체적약속.비교량조계화적파구、위급기관화정상조직적제량분포.결과 6화18 MV계화적평균PTV100분별시95.6%화95.3%(검험치P=0.26),Dmean분별시52.55 Gy화52.60 Gy(P=0.54),괄형지수분별시0.87화0.88(P=0.03),균균성지수균위1.10(P=0.38).18 MV계화교6 MV계화정상조직적평균적분제량하강료2.4%(P=0.001),소장화결장적평균V30화V50분별하강료4.2%(P=0.006)화3.3%(P=0.046),기타위급기관적제량분포간차이무통계학의의.결론 대우자궁내막암적술후전분강조강방사치료,18 MV계화비6 MV계화제량분포적괄형도경호,능구경호지보호정상조직、소장화결장.량조계화파구적복개도화제량분포적균균성,이급직장、방광화분강골적보호상당.
Objective To investigate the effect of beam energy on the quality of postoperative whole pelvic IMRT plans for endometrial cancer.Methods Computed Tomography (CT) image sets of ten postoperative endometrial cancer patients were acquired and two whole pelvic IMRT plans were created for each patient,one with 6 MV and the other with 18 MV photons.Beam arrangements and optimization constraints were the same for two plans.The dose distribution of the targets,organs at risk and normal tissue was analyzed and compared for plans generated with both energies.Results The mean PIV100 were 95.6% and 95.3% ( P=0.26),the Dmean were 52.55 Gy and 52.60 Gy (P=0.54) for the plans with 6-and 18-MV photons,respectively.The mean conformity index were 0.87 and 0.88 (P=0.03).The mean homogeneity index were both 1.10 ( P=0.38).The mean integral dose to normal tissue was 2.4% lower with 18 MV plans ( P=0.00),the mean V30 and V50 of small intestine and colon were also reduced by 4.2% ( P=0.006) and 3.3% (P=0.046),respectively.No statistically significant difference was found for the dose distribution to the other organs at risk between the plans with 6-and 18-MV photons.Conclusions Compared with 6 MV IMRT plans,18 MV IMRT plans resuhed in more conformal dose distribution,better sparing of small intestine and colon,and normal tissue,with comparable PTV coverage and sparing of rectum,bladder,and pelvic bones.
