CAJ | 학술논문

目的评价脑胶质瘤调强放射治疗较三维适形放射治疗的剂量学优势.方法本研究采用10例脑胶质瘤患者,针对所有患者分别进行3D CRT和IMRT的计划设计,利用剂量体积直方图评价不同照射技术中靶区和正常组织照射剂量、适形度指数和不均匀性指数.处方剂量为60 Gy.结果 IMRT计划脑干最大剂量和受照体积、患侧腮腺平均剂量和脊髓最大剂量均低于3D CRT计划.对于靶区适形度指数,IMRT计划优于3D CRT计划;对于不均匀性指数,两种计划模式的差异没有统计学意义.结论在脑胶质瘤放疗中应用IMRT可以明显降低脑干的剂量和受照体积,为靶区剂量的提高提供了可能性.
목적 평개뇌효질류조강방사치료교삼유괄형방사치료적제량학우세.방법 본연구채용10례뇌효질류환자,침대소유환자분별진행3D CRT화IMRT적계화설계,이용제량체적직방도평개불동조사기술중파구화정상조직조사제량、괄형도지수화불균균성지수.처방제량위60 Gy.결과 IMRT계화뇌간최대제량화수조체적、환측시선평균제량화척수최대제량균저우3D CRT계화.대우파구괄형도지수,IMRT계화우우3D CRT계화;대우불균균성지수,량충계화모식적차이몰유통계학의의.결론 재뇌효질류방료중응용IMRT가이명현강저뇌간적제량화수조체적,위파구제량적제고제공료가능성.
Objective To investigate the dosimetry advantages of intensity modulated radiotherapy (IMRT) of brain glioma compared with that of three-dimensional conformal radiotherapy (3D CRT).Methods Ten patients with brain glioma were enrolled in this study.Three-dimensional conformal and intensity modulated radiotherapy plans were performed for each patient.The dose distributions of target volume and normal tissues,conformal index (CI) and heterogeneous index (HI) were analyzed using the dose-volume histogram (DVH).The prescription dose was 60 Gy in 30 fractions.Results IMRT plans decrease the maximum dose and volume of brainstem,mean dose of affected side parotid and maximum dose of spinal-cord.The CI for PTV of IMRT was superior to that of 3D CRT,the HI for PTV has no statistical significance of the two model plans.Conclusions IMRT plans can obviously decrease the dose and volume of brainstem.IMRT is a potential method in the treatment of brain glioma,and dose escalation was possible in patients with brain glioma.