CAJ | 학술논문

目的探讨影响伽玛刀治疗原发性视神经鞘脑膜瘤(PONSM)术后视力控制效果的相关因素.方法收集本院伽玛刀治疗中心收治的26例PONSM患者,2例经病理证实,24例经MRI表现结合临床特征诊断.所有患者术后均定期复诊,通过分析肿瘤控制率及视力控制率评定疗效.评估伽玛刀治疗参数、患者不同临床特征及术前MRI表现对视力预后情况是否产生影响.结果经过6～62个月随访,视力控制率为65.4％,肿瘤控制率为96.2％.发病年龄(P=0.034)、起病急缓(P =0.014)及术前肿瘤形态(P=0.034)与伽玛刀术后视力控制有显著关系.结论伽玛刀治疗PONSM疗效较好,其术后视力控制效果主要取决于患者的发病年龄、起病急缓,并与伽玛刀术后出现的放射性损伤程度有关.
목적 탐토영향가마도치료원발성시신경초뇌막류(PONSM)술후시력공제효과적상관인소.방법 수집본원가마도치료중심수치적26례PONSM환자,2례경병리증실,24례경MRI표현결합림상특정진단.소유환자술후균정기복진,통과분석종류공제솔급시력공제솔평정료효.평고가마도치료삼수、환자불동림상특정급술전MRI표현대시력예후정황시부산생영향.결과 경과6～62개월수방,시력공제솔위65.4％,종류공제솔위96.2％.발병년령(P=0.034)、기병급완(P =0.014)급술전종류형태(P=0.034)여가마도술후시력공제유현저관계.결론 가마도치료PONSM료효교호,기술후시력공제효과주요취결우환자적발병년령、기병급완,병여가마도술후출현적방사성손상정도유관.
Objective To investigate the effect of gamma knife surgery (GKS) in treatment of primary orbital optic nerve sheath meningioma (PONSM) upon visual control and to explore the factors influencing the visual acuity changes after GKS.Methods Totally 26 PONSM patients,3 males and 23 females,aged 35.5 (4-66) years old,2 pathologically confirmed and 24 confirmed by MRI,underwent GKS,and were followed up for 20.2 months (6-62 months).The efficacy of GKS was evaluated by the change of tumor volume and visual acuity.The relations between the change of visual acuity and different clinical features were analyzed.Results The vision control rate was 65.4％,and the tumor control rate was 96.2％.The onset age,onset speed,and preoperative shape of PONSM were significantly correlated with the visual change after GKS (P =0.034,0.014,and 0.034 respectively).Conclusions The efficacy of GKS in patients with PONSM is fine,which depends on the onset age,onset speed,as well as the degree of radiation-induced side effect after GKS.