中华放射医学与防护杂志
中華放射醫學與防護雜誌
중화방사의학여방호잡지
Chinese Journal of Radiological Medicine and Protection
2014年
4期
250-254
,共5页
姜晶%高露%黄波%周平坤%让蔚清
薑晶%高露%黃波%週平坤%讓蔚清
강정%고로%황파%주평곤%양위청
放射工作人员%电离辐射%染色体畸变%微核细胞%Meta分析
放射工作人員%電離輻射%染色體畸變%微覈細胞%Meta分析
방사공작인원%전리복사%염색체기변%미핵세포%Meta분석
Radiological workers%Ionizing radiation%Chromosome aberrations%Micronucleus cells%Meta analysis
目的 用Meta分析的方法综合定量分析电离辐射对职业暴露人群染色体畸变率和微核细胞率的影响.方法 全面检索国内外中英文相关文献,按预先设定的纳入排除标准进行严格筛选后,最终纳入21篇文献,总研究细胞数1 970 626个.用Stata 12.0进行Meta分析,异质性检验用Q检验和I2统计量,发表偏倚用漏斗图法、Begg秩相关法和Egger线性回归法3种方法识别.结果 放射工作人员发生染色体型畸变、双着丝粒体+环状染色体畸变、易位、微核细胞的危险性要高于非放射工作人员,其比值比及95％的可信区间分别为3.03 (2.59,3.56)、4.12 (2.99,5.67)、2.73 (1.67,4.46)、1.70 (1.40,2.06).结论 长期暴露在低剂量电离辐射下会显著增加外周血淋巴细胞染色体畸变率和微核细胞率,应加强放射工作人员的辐射防护.
目的 用Meta分析的方法綜閤定量分析電離輻射對職業暴露人群染色體畸變率和微覈細胞率的影響.方法 全麵檢索國內外中英文相關文獻,按預先設定的納入排除標準進行嚴格篩選後,最終納入21篇文獻,總研究細胞數1 970 626箇.用Stata 12.0進行Meta分析,異質性檢驗用Q檢驗和I2統計量,髮錶偏倚用漏鬥圖法、Begg秩相關法和Egger線性迴歸法3種方法識彆.結果 放射工作人員髮生染色體型畸變、雙著絲粒體+環狀染色體畸變、易位、微覈細胞的危險性要高于非放射工作人員,其比值比及95％的可信區間分彆為3.03 (2.59,3.56)、4.12 (2.99,5.67)、2.73 (1.67,4.46)、1.70 (1.40,2.06).結論 長期暴露在低劑量電離輻射下會顯著增加外週血淋巴細胞染色體畸變率和微覈細胞率,應加彊放射工作人員的輻射防護.
목적 용Meta분석적방법종합정량분석전리복사대직업폭로인군염색체기변솔화미핵세포솔적영향.방법 전면검색국내외중영문상관문헌,안예선설정적납입배제표준진행엄격사선후,최종납입21편문헌,총연구세포수1 970 626개.용Stata 12.0진행Meta분석,이질성검험용Q검험화I2통계량,발표편의용루두도법、Begg질상관법화Egger선성회귀법3충방법식별.결과 방사공작인원발생염색체형기변、쌍착사립체+배상염색체기변、역위、미핵세포적위험성요고우비방사공작인원,기비치비급95％적가신구간분별위3.03 (2.59,3.56)、4.12 (2.99,5.67)、2.73 (1.67,4.46)、1.70 (1.40,2.06).결론 장기폭로재저제량전리복사하회현저증가외주혈림파세포염색체기변솔화미핵세포솔,응가강방사공작인원적복사방호.
Objective To quantitatively investigate the effect of low-dose ionizing radiation on the frequencies of chromosome aberrations and micronucleus-containing cells of radiation workers.Methods Nine electronic databases were systematically searched on the basis of the published studies evaluating the effects of low-dose ionizing radiation on the frequencies of chromosome aberrations and micronucleuscontaining cells.Of the 195 studies searched,21 studies were identified with a total of 1 970 626 cells under studying.Cochrane' s Q and I2 statistics were used to evaluate heterogeneity among studies and pooling odds ratio (OR) with 95％ confidence intervals (CI) were calculated using random-effect models or fixed-effect models,and publication bias were also calculated.Meta-analysis was performed using Stata 12.0.Results The pooling OR of chromosome-type aberrations [OR =3.03 (2.59,3.56)],dicentric plus centric rings [OR =4.12 (2.99,5.67)],translocations [OR =2.73 (1.67,4.46)],micronucleuscontaining cells [OR =1.70 (1.40-2.06)] were higher for radiation workers when compared with control group.Conclusions The frequencies of chromosome aberrations and micronucleus cell of peripheral lymphocytes are significantly high in radiation workers who were occupationally exposed to low-dose ionizing radiation.It should be noted that the radiation protection of radiological workers be enhanced.
