CAJ | 학술논문

目的观察肿瘤保守性切除联合125I放射性粒子组织间永久植入治疗早期腮腺癌的临床疗效.方法选取2004年11月至2012年6月在北京大学口腔医院就诊的腮腺癌患者共30例,所有患者行腮腺肿瘤保守性切除,术后联合125I放射性粒子组织间永久植入治疗.中位随访时间41个月,观察临床疗效及并发症.结果患者的5年生存率及无瘤生存率为100％,无局部复发及远处转移.手术后暂时性面神经损伤发生率为3.33％ (1/30),无永久性面瘫发生,未见放射性骨髓炎、耳聋、重度张口受限等.结论肿瘤保守性切除联合125I放射性粒子组织间永久植入治疗早期腮腺癌临床效果良好,可保存面形,保留面神经,降低并发症发生率,提高患者生存质量.
목적 관찰종류보수성절제연합125I방사성입자조직간영구식입치료조기시선암적림상료효.방법 선취2004년11월지2012년6월재북경대학구강의원취진적시선암환자공30례,소유환자행시선종류보수성절제,술후연합125I방사성입자조직간영구식입치료.중위수방시간41개월,관찰림상료효급병발증.결과 환자적5년생존솔급무류생존솔위100％,무국부복발급원처전이.수술후잠시성면신경손상발생솔위3.33％ (1/30),무영구성면탄발생,미견방사성골수염、이롱、중도장구수한등.결론 종류보수성절제연합125I방사성입자조직간영구식입치료조기시선암림상효과량호,가보존면형,보류면신경,강저병발증발생솔,제고환자생존질량.
Objective To assess the efficacy of conservative parotidectomy combined with 125I seed implant brachytherapy for patients with early parotid gland carcinomas.Methods Thirty patients with malignant parotid gland tumors underwent conservative parotidectomy while preserving facial nerve from November 2004 to June 2012.No patient underwent neck dissection simultaneously with the primary lesion.The treatment planning system was utilized for brachytherapy design,and followed by 125I seed implantation into the target area postoperatively.The patients were followed up from 16 to 106 months,with a median duration of 41 months.The tumor recurrence was observed,while facial nerve function and radiation therapy toxicity were recorded.Results Both the 5-year survival rate and the disease-free survival rate were 100％.There was no loco-regional recurrence and metastasis.Temporary postoperative facial nerve dysfunction occurred in one patient (1/30),no permanent facial injury was observed.Severe radiation toxicity was rare.Conclusions Conservative parotidectomy combined with 125I seed implant brachytherapy may be acceptable for early malignant parotid gland tumors,with preservation of the facial nerve,diminishing deformation and rare severe radiation toxicity.