CAJ | 학술논문

目的探讨320排容积CT全脑灌注成像扫描协议优化的可行性.方法 20名健康志愿者按随机数字表法分为对照组和试验组,对照组7例,选择标准灌注扫描协议(19圈容积采集);试验组13例,通过合理改变采集间隔,减少扫描期相,采用一组新的灌注扫描协议(11圈容积采集).图像分析感兴趣区(ROI)设为两侧额叶白质、顶叶白质、半卵圆区、基底节区、枕叶、小脑,大小约(20±2)mm2.计算得到各感兴趣区的灌注参数值,包括脑血容量(rCBV)、达峰时间(TTP)、脑血流量(rCBF)、平均通过时间(MTT)及延迟时间(DT).结果试验组剂量长度乘积(DLP)和有效剂量(E)较对照组降低了42.02％.两组不同层面左右两侧ROI区的各灌注参数的差异无统计学意义.两组组间上述各个对应部位的ROI区各灌注参数无明显差别.结论优化后的扫描协议得到了与厂家推荐的标准协议无差异的全脑灌注参数值且降低了辐射剂量,推荐常规使用.
목적 탐토320배용적CT전뇌관주성상소묘협의우화적가행성.방법 20명건강지원자안수궤수자표법분위대조조화시험조,대조조7례,선택표준관주소묘협의(19권용적채집);시험조13례,통과합리개변채집간격,감소소묘기상,채용일조신적관주소묘협의(11권용적채집).도상분석감흥취구(ROI)설위량측액협백질、정협백질、반란원구、기저절구、침협、소뇌,대소약(20±2)mm2.계산득도각감흥취구적관주삼수치,포괄뇌혈용량(rCBV)、체봉시간(TTP)、뇌혈류량(rCBF)、평균통과시간(MTT)급연지시간(DT).결과 시험조제량장도승적(DLP)화유효제량(E)교대조조강저료42.02％.량조불동층면좌우량측ROI구적각관주삼수적차이무통계학의의.량조조간상술각개대응부위적ROI구각관주삼수무명현차별.결론 우화후적소묘협의득도료여엄가추천적표준협의무차이적전뇌관주삼수치차강저료복사제량,추천상규사용.
Objective To evaluate the feasibility of optimized scan protocol in whole-brain perfusion imaging with 320-MDCT scanner.Methods Twenty healthy volunteers were randomly divided into control group (13 patients) and test group (7 patients).The standard perfusion scan protocol (collecting 19 volumes)was applied in control group.The optimized perfusion CT scan protocol(collecting ll volumes)formulated by reducing scanning phases reasonably and changing the collection intervals was applied in test group.The regions of interest(ROI) with area of(20 ± 2)mm2 were located in the bilateral frontal white matter,parietal white matter,centrum semiovate,basal ganglia,occipital lobe and cerebellum.Bilateral perfusion values from ROI were measured,including cerebral blood volume(CBV),mean transit time (TTP),cerebral blood flow (CBF),mean transit time (MTT) and delay time (DT).Results Dose length product (DLP)and effective dose (ED)in optimized protocol were decreased 42.02％ as compared to control group.Every relative perfusion value of both sides from both groups were not statistically significant (P ＞ 0.05).Every relative perfusion parameters from individual territory in both groups showed no significant differences (P ＞ 0.05).Conclusions Using the optimized scan protocol,we could obtain the same whole-brain perfusion values could be obtained with the default standard protocol and less radiation dose.