CAJ | 학술논문

目的探讨18F-脱氧葡萄糖(18F-FDG)和18F-赤硝基咪唑(18F-FETNIM)双示踪剂PET-CT确定头颈部肿瘤生物适形调强放射治疗(BIMRT)靶区的可行性.方法经病理证实且未经治疗的头颈部肿瘤患者12例,治疗前行CT模拟定位扫描、18F-FDG PET-CT和18F-FETNIM PET-CT扫描,分别勾画大体肿瘤靶区(GTVCT)、葡萄糖代谢亚靶区(GTVFDG)、乏氧亚靶区(GTVFETNIM),测量并比较原发肿瘤和转移性淋巴结体积,分别表示为GTVP-CT、GTVN-CT、GTVP-FDG、GTVN-FDG、GTV P-FETNIM和GTVN-FETNIM.结果 12例患者原发肿瘤和转移淋巴结均摄取18F-FDG,SUVmax-P和SUVmax-N分别为12.3±5.5和5.1±2.8.9例患者原发肿瘤摄取18F-FETNIM,其中5例患者转移性淋巴结有摄取,未见摄取4例;3例患者原发肿瘤未见18F-FETNIM摄取,其中转移性淋巴结有摄取1例,未见摄取2例.GTVP-CT、GTVP-FDG和GTV P-FETNIM分别为(22.23±12.11)、(20.83±11.59)和(1.98±1.81)cm3,GTVN-cT、GTVN-FDG和GTV N-FETNIM分别为(10.77±8.87)、(10.41±8.61)和(0.61±1.08) cm3.GTVP-FETNIM＜GTVP-CT,GTVP-FETNIM＜GTVP-FDG,GTVN-FETNIM＜GTVN-CT,GTVN-FETNIM＜GTVN-FDG(P＜0.01),GTVP-CT与GTVP-FDG、GTVN-CT与GTVN-FDG差异无统计学意义.结论不同示踪剂PET-CT显像反映肿瘤细胞不同方面的生物学信息,根据PET-CT影像所显示的示踪剂高摄取区域将肿瘤组织划分为若干个子区域是可行的,为实现生物调强放疗提供了可靠的研究基础.
목적 탐토18F-탈양포도당(18F-FDG)화18F-적초기미서(18F-FETNIM)쌍시종제PET-CT학정두경부종류생물괄형조강방사치료(BIMRT)파구적가행성.방법 경병리증실차미경치료적두경부종류환자12례,치료전행CT모의정위소묘、18F-FDG PET-CT화18F-FETNIM PET-CT소묘,분별구화대체종류파구(GTVCT)、포도당대사아파구(GTVFDG)、핍양아파구(GTVFETNIM),측량병비교원발종류화전이성림파결체적,분별표시위GTVP-CT、GTVN-CT、GTVP-FDG、GTVN-FDG、GTV P-FETNIM화GTVN-FETNIM.결과 12례환자원발종류화전이림파결균섭취18F-FDG,SUVmax-P화SUVmax-N분별위12.3±5.5화5.1±2.8.9례환자원발종류섭취18F-FETNIM,기중5례환자전이성림파결유섭취,미견섭취4례;3례환자원발종류미견18F-FETNIM섭취,기중전이성림파결유섭취1례,미견섭취2례.GTVP-CT、GTVP-FDG화GTV P-FETNIM분별위(22.23±12.11)、(20.83±11.59)화(1.98±1.81)cm3,GTVN-cT、GTVN-FDG화GTV N-FETNIM분별위(10.77±8.87)、(10.41±8.61)화(0.61±1.08) cm3.GTVP-FETNIM＜GTVP-CT,GTVP-FETNIM＜GTVP-FDG,GTVN-FETNIM＜GTVN-CT,GTVN-FETNIM＜GTVN-FDG(P＜0.01),GTVP-CT여GTVP-FDG、GTVN-CT여GTVN-FDG차이무통계학의의.결론 불동시종제PET-CT현상반영종류세포불동방면적생물학신식,근거PET-CT영상소현시적시종제고섭취구역장종류조직화분위약간개자구역시가행적,위실현생물조강방료제공료가고적연구기출.
Objective To evaluate the feasibility of using Fluorine-18 fluorodeoxyglucose (18F-FDG) and Fluorine-18 fluoroerythronitroimidazole (18 F-FETNIM) in positron emission tomography with computed tomography (PET-CT) to define biological target volume during the biological intensity modulated radiotherapy (BIMRT).Methods Twelve patients with pathologically confirmed head and neck cancer were scanned with CT simulation,18F-FDG PET-CT and 18F-FETNIM PET-CT respectively before treatment.Three gross target volumes,GTVCT,GTVFDG and GTVFETNIM,were delineated correspondingly with three modalities.The volumes of primary tumor (P-) and metastatic lymph nodes (N-),denoted as GTVP-cT,GTVN-cT,GTVP-FDG,GTVN-FDG,GTVP-FETNIM and GTVN-FETNIM,were compared respectively.Results Both primary tumor and metastatic lymph node of the 12 patients had 18F-FDG uptake,and the average maximal standard uptake values (SUVmax) were 12.3 ±5.5 and 5.1 ±2.8,respectively.Positive primary tumor 18F-FETNIM uptake was observed in 9 patients,yet only 5 of whom had positive 18F-FETNIM uptake in lymph node metastases.Three patients had no 18F-FETNIM uptake in the primary tumor,among whom 1 had positive 18F-FETNIM uptake in lymph node metastases.The volumes of GTVP-CT,GTVP-FDG and GTVP-F-ETNIM were (22.23 ± 12.11),(20.83 ± 11.59) and (1.98 ± 1.81) cm3,respectively.The volumes of GTVN-CT,GTVN-FDC and GTVN-FETNIM were (10.77 ± 8.87),(10.41 ± 8.61) and (0.61 ± 1.08) cm3,respectively.Compared to CT imaging,the volume differences of primary tumor and metastatic lymph nodes shown on 18F-FDG PET-CT imaging were statistically not significant.Compared with CT and 18F-FDG PET-CT,the corresponding volumes were significantly smaller at 18F-FETNIM PET-CT (P ＜0.01).Conclusions The study demonstrated that PET-CT imaging using different tracers may define subregions of the tumor for biological target volume delineation,which provides foundations for BIMRT.