CAJ | 학술논문

目的探讨局部无进展生存(LPFS)评价射波刀治疗外周型肺肿瘤局部远期疗效的价值.方法回顾分析射波刀治疗肺转移瘤或原发瘤患者81例资料,其中原发肺肿瘤43例43个病灶,肺转移瘤38例47个病灶.58例63个病灶接受60 Gy分3次治疗(20 Gy/次),23例27个病灶接受54Gy分3次治疗(18 Gy/次).以近期疗效和LPFS为观察指标,Logistic法分析LPFS对局部远期疗效的预测作用.结果近期疗效评价后全组63％病灶需后续复查中再评价,随时间延长需再评价病灶逐渐减少,且以6个月至2年减少最为迅速.再次疗效评价对后续随访疗效评价均有预测作用,但随时间延长预测作用逐渐减弱.结论 LPFS是射波刀治疗局部有效的早期原发肺肿瘤或肺转移瘤可推荐的局部疗效评价指标,且对局部远期疗效也有预测价值.
목적 탐토국부무진전생존(LPFS)평개사파도치료외주형폐종류국부원기료효적개치.방법 회고분석사파도치료폐전이류혹원발류환자81례자료,기중원발폐종류43례43개병조,폐전이류38례47개병조.58례63개병조접수60 Gy분3차치료(20 Gy/차),23례27개병조접수54Gy분3차치료(18 Gy/차).이근기료효화LPFS위관찰지표,Logistic법분석LPFS대국부원기료효적예측작용.결과 근기료효평개후전조63％병조수후속복사중재평개,수시간연장수재평개병조축점감소,차이6개월지2년감소최위신속.재차료효평개대후속수방료효평개균유예측작용,단수시간연장예측작용축점감약.결론 LPFS시사파도치료국부유효적조기원발폐종류혹폐전이류가추천적국부료효평개지표,차대국부원기료효야유예측개치.
Objective To investigate the value of local progression-free survival (LPFS) for evaluating the local long-term outcome of peripheral lung cancer treated by cyberknife.Methods Retrospective analysis was performed on the clinical records of 81 cyberknife-treated lung cancer patients (90 foci),including 43 primary lung cancer patients (43 foci) and 38 metastatic lung cancer patients (47 foci).Of all the patients,58(63 foci) were treated at a dose of 60 Gy/3 fractions (20 Gy/fraction),and 23 (27 foci) at a dose of 54 Gy/3 fractions (18 Gy/fraction).The short-term treatment outcome and LPFS were used as the indices for observation;a logistic regression was used for analyzing the predictive value of LPFS for local long-term treatment outcome.Results After the evaluation of short-term treatment outcome,63％ of all the foci needed further evaluation.As the follow-up lasted,the number of foci which needed further evaluation decreased,most rapidly during 0.5-2 years after treatment.Re-evaluation results had predictive value for the treatment outcome in the subsequent follow-up,but the predictive value declined as the follow-up lasted.Conclusions LPFS is a recommendable index for evaluating the local outcome of primary or metastatic lung cancer treated by cyberknife,and it also has predicative value for local long-term treatment outcome.