CAJ | 학술논문

目的探讨CTVision引导下非小细胞肺癌立体定向放疗的精确性.方法 2010-2012年应用西门子ONCOR CTVision加速器对10例非小细胞肺癌患者行立体定向放疗,采集每位患者每次放疗前后CT图像并与治疗计划CT图像进行匹配,在线调整并分析患者放疗前后位移误差.通过离线勾画每位患者每次放疗前后(共8次)大体肿瘤体积,融合8次靶区得到内靶体积,通过比较内靶体积和计划靶体积进行离线验证治疗过程准确性.配对样本t检验差异.结果分析10例肺癌患者放疗前后80次CT扫描数据,结果显示放疗前和后在左右、上下、前后方向位移误差均相似,分别为(-0.10±1.30)mm和(-0.15±1.31)mm (P =0.720)、(0.18±1.32) mm和(0.18±1.43) mm (P=1.000)、(-0.08±1.19)mm和(-0.13±1.18)mm (P=0.750).内靶区的体积均小于计划靶区体积,分别为13.53 cm3和37.84 cm3(p =0.000).结论 CTVision加速器能够确保肺癌患者立体定向放疗的准确性和安全性.
목적 탐토CTVision인도하비소세포폐암입체정향방료적정학성.방법 2010-2012년응용서문자ONCOR CTVision가속기대10례비소세포폐암환자행입체정향방료,채집매위환자매차방료전후CT도상병여치료계화CT도상진행필배,재선조정병분석환자방료전후위이오차.통과리선구화매위환자매차방료전후(공8차)대체종류체적,융합8차파구득도내파체적,통과비교내파체적화계화파체적진행리선험증치료과정준학성.배대양본t검험차이.결과 분석10례폐암환자방료전후80차CT소묘수거,결과현시방료전화후재좌우、상하、전후방향위이오차균상사,분별위(-0.10±1.30)mm화(-0.15±1.31)mm (P =0.720)、(0.18±1.32) mm화(0.18±1.43) mm (P=1.000)、(-0.08±1.19)mm화(-0.13±1.18)mm (P=0.750).내파구적체적균소우계화파구체적,분별위13.53 cm3화37.84 cm3(p =0.000).결론 CTVision가속기능구학보폐암환자입체정향방료적준학성화안전성.
Objective To investigate the accuracy of CTVision image-guided stereotactic body radiation therapy (SBRT) for non-small cell lung cancer (NSCLC).Methods 10 lung SBRT patients were imaged with CTVision before and after irradiation for acquiring and analyzing the three-dimensional set-up error data sets in our department from October 2010 to May 2012.Gross tumor volumes (GTVs) were contoured on pre-and post-SBRT CT sets and combined for generating internal gross tumor volumes (IGTVs).Planning target volume (PTV) margin was calculated,and IGTVs and PTVs were compared for off-line verification of accuracy of SBRT.A paired t-test statistical analysis was conducted with the datasets using SPSS 17.0.Results 80 CT image sets were totally obtained.Setup errors was significant difference before and after radiotherapy in the left-right,superior-inferior and anterior-posterior directions,that were (-0.10±1.30) mmand (-0.15±1.31) mm (P=0.720),(0.18±1.32) mm and (0.18±1.43) mm (P =1.000) and (-0.08 ± 1.19) mm and (-0.13 ± 1.18) mm (P =0.750),respectively.IGTVs of ten patients were smaller than corresponding PTVs (13.53 cm3 and 37.84 cm3,P =0.000).Conclusion Accuracy and safety of SBRT could be verified by imaging with CTVision before and after delivery for non-small cell lung cancer.