CAJ | 학술논문

目的探讨治疗前18F 2-脱氧D-葡萄糖(18F-FDG)PET/CT显像在中晚期胰腺癌患者预后评估中的临床价值.方法回顾2005年4月至2011年10月临床可疑胰腺癌并行18F-FDG PET/CT检查的106例患者资料,分析PET/CT显像及其他预后相关因素与患者生存指标之间的关系,研究PET/CT显像在中晚期胰腺癌患者预后评估中的价值.结果 Kaplan-Meier单因素分析显示,A组(SUVmax值≤7.6)与B组(SUVmax值＞7.6)患者的生存时间分别为(203.0±22.7)d与(141.0±18.2)d,差异有统计学意义(P＜0.01)；不同PET/CT分期患者之间的生存时间差异有统计学意义(P＜0.05).Cox多因素分析显示,SUVmax值和PET/CT分期是患者长期生存的独立影响因素.结论治疗前的18F FDG PET/CT分期及肿瘤原发部位的SUVmax值在评估中晚期胰腺癌患者预后方面具有一定的临床价值,能够指导临床尽早制定个体化治疗方案,对提高疾病的治疗疗效、延长患者生存期具有较大意义.
목적 탐토치료전18F 2-탈양D-포도당(18F-FDG)PET/CT현상재중만기이선암환자예후평고중적림상개치.방법 회고2005년4월지2011년10월림상가의이선암병행18F-FDG PET/CT검사적106례환자자료,분석PET/CT현상급기타예후상관인소여환자생존지표지간적관계,연구PET/CT현상재중만기이선암환자예후평고중적개치.결과 Kaplan-Meier단인소분석현시,A조(SUVmax치≤7.6)여B조(SUVmax치＞7.6)환자적생존시간분별위(203.0±22.7)d여(141.0±18.2)d,차이유통계학의의(P＜0.01)；불동PET/CT분기환자지간적생존시간차이유통계학의의(P＜0.05).Cox다인소분석현시,SUVmax치화PET/CT분기시환자장기생존적독립영향인소.결론 치료전적18F FDG PET/CT분기급종류원발부위적SUVmax치재평고중만기이선암환자예후방면구유일정적림상개치,능구지도림상진조제정개체화치료방안,대제고질병적치료료효、연장환자생존기구유교대의의.
Objective To evaluate the role of 18F-FDG PET/CT imaging in predicting prognosis of patients with pancreatic carcinoma.Methods From April 2005 to October 2011,106 patients with clinically suspected pancreatic carcinoma were examined by 18F-FDG PET/CT.There were 57 males and 49 females.The age ranged from 33 to 85 years,with a median of 63 years.The patients were confirmed to have pancreatic carcinoma by histopathology (n 55) or by long-term clinical follow-up (n=51).The role of PET/CT imaging in predicting prognosis of patients with pancreatic carcinoma was retrospectively analyzed.Results At the time of censor,85 patients had died,11 patients were alive and 10 patients were lost to follow-up.Kaplan-Meier analysis showed that the survival periods between patients in group A (SUVmax≤7.6) and group B (SUVmax＞7.6) were significantly different (203.0±22.7)d,(141.0±18.2)d,P＜0.01.The survival periods for patients in different PET/CT stagings were also significantly different,P＜0.05.Cox multi factor analyses indicated that the maxi-mum standardized uptake value (SUVmax) and PET/CT staging were independent risk factors of long-term survivals.Conclusions The PET/CT staging and SUV of the primary tumor before treatment were useful in predicting prognosis of patients with pancreatic carcinoma,suggesting that they can be used to guide individual treatment for patients with pancreatic carcinoma.