CAJ | 학술논문

目的探讨Gli1、Gli3蛋白在肝细胞癌组织中的表达及临床意义.方法免疫组化法检测36例肝细胞癌组织及其癌旁肝组织中Gli1、Gli3蛋白的表达,并与临床因素进行相关性分析.结果在肝细胞癌组织及癌旁肝组织中Gli1的阳性表达率分别为75％和36.1％,Gli3的阳性表达率分别为58.3％和30.6％.Gli1和Gli3在肝细胞癌组织中的阳性表达率显著高于癌旁肝组织(P＜0.05).Gli1和Gli3两种蛋白的表达呈正相关(r=0.423,P＜0.05).Gli3的表达与临床指标(年龄、肿瘤大小、分化和淋巴结转移)无关.Gli1的表达与年龄、肿瘤大小无关,但与肿瘤分化程度和淋巴结转移相关(P＜0.05).结论 Gli1、Gli3蛋白在肝细胞癌组织中有较高的阳性表达率且具有相关性,且Gli1的表达率与肿瘤分化程度和淋巴结转移相关.检测Gli1、Gli3蛋白表达有助于肝细胞癌的诊断,可能作为判断肝细胞癌恶性程度及预后的指标.
목적 탐토Gli1、Gli3단백재간세포암조직중적표체급림상의의.방법 면역조화법검측36례간세포암조직급기암방간조직중Gli1、Gli3단백적표체,병여림상인소진행상관성분석.결과 재간세포암조직급암방간조직중Gli1적양성표체솔분별위75％화36.1％,Gli3적양성표체솔분별위58.3％화30.6％.Gli1화Gli3재간세포암조직중적양성표체솔현저고우암방간조직(P＜0.05).Gli1화Gli3량충단백적표체정정상관(r=0.423,P＜0.05).Gli3적표체여림상지표(년령、종류대소、분화화림파결전이)무관.Gli1적표체여년령、종류대소무관,단여종류분화정도화림파결전이상관(P＜0.05).결론 Gli1、Gli3단백재간세포암조직중유교고적양성표체솔차구유상관성,차Gli1적표체솔여종류분화정도화림파결전이상관.검측Gli1、Gli3단백표체유조우간세포암적진단,가능작위판단간세포암악성정도급예후적지표.
Objective This study analyzes the expression and clinical significance of Gli1 and Gli3 proteins in hepatocellular carcinoma.Methods 36 patients with hepatocellular carcinoma were studied.The expressions of Gli1 and Gli3 in the carcinoma and adjacent non-tumor tissues were detected with immunohistochemical assay,and their correlations with clinicopathological factors were statistically analyzed.Results Expression rates of Gli1 in hepatocellular carcinoma and adjacent nontumor tissues were 75 ％ and 36.1％,respectively.Expression rates of Gli3 in hepatocellular carcinoma and adjacent non-tumor tissues were 58.3％ and 30.6％,respectively.Expression rates of Gli1 and Gli3 in hepatocellular carcinoma were significantly higher than in adjacent non-tumor tissues (P＜0.05),and a positive correlation was found between the expression of Gli1 and Gli3 (r=0.423,P＜0.05).There was no association between the expression of Gli3 and clinicopathological factors such as age,tumor size,tumor differentiation and lymphatic metastasis.The expression of Gll1 was not related witha patient's age and tumor size,hut there were significant associations with tumor differentiation and lymphatic metastasis.Conclusions Therefore,the expression rate of Gli1 was positively correlated with tumor malignancy,which makes the detection of Gli1 and Gli3 valuable for the diagnosis and prognosis of hepatocellular carcinoma.