CAJ | 학술논문

目的探索胰腺导管内乳头状黏液性肿瘤(IPMN)的临床特征,为该疾病的临床诊断提供参考依据.方法以PubMed为检索数据库,对2006年7月1日至2011年6月30日已发表的关于胰腺IPMN文献中经病理学证实的临床病例进行汇集分析,主要内容包括病例的人口统计学信息、主要临床表现、主要相关伴随疾病、肿瘤的形态学类型、解剖学分布特征、病理学类型等.结果共汇集文献123篇,病例6548例.胰腺IPMN多发于老年人,男性较女性略多.胰腺IPMN可发生于胰腺的各个部位,以胰头部多见,其次为胰体尾部以及弥漫性分布.在其三种形态学类型中,支胰管型最为多见.胰腺IPMN主要临床表现缺乏特异性,以上腹部疼痛、体重减轻及黄疸最为多见.在汇集的病例中,恶性肿瘤病例达半数.结论胰腺IPMN的临床表现缺乏特异性.在临床工作中应警惕胰腺IPMN的存在.应在对其临床特征进行综合分析后,结合患者的自身状况进一步制定治疗方案.
목적 탐색이선도관내유두상점액성종류(IPMN)적림상특정,위해질병적림상진단제공삼고의거.방법 이PubMed위검색수거고,대2006년7월1일지2011년6월30일이발표적관우이선IPMN문헌중경병이학증실적림상병례진행회집분석,주요내용포괄병례적인구통계학신식、주요림상표현、주요상관반수질병、종류적형태학류형、해부학분포특정、병이학류형등.결과 공회집문헌123편,병례6548례.이선IPMN다발우노년인,남성교녀성략다.이선IPMN가발생우이선적각개부위,이이두부다견,기차위이체미부이급미만성분포.재기삼충형태학류형중,지이관형최위다견.이선IPMN주요림상표현결핍특이성,이상복부동통、체중감경급황달최위다견.재회집적병례중,악성종류병례체반수.결론 이선IPMN적림상표현결핍특이성.재림상공작중응경척이선IPMN적존재.응재대기림상특정진행종합분석후,결합환자적자신상황진일보제정치료방안.
Objective To analyze the clinical characterisaics of pancreatic intraductal papillary mucinous neoplasm (IPMN),which may provide references for its clinical diagnosis and treatment.Methods PubMed was used as a searching database to collect all the pancreatic IPMN related articles with positive pathologic results from July,2006 to June,2011.A pooled analysis was then performed.The main analysis included demographic information,main clinical manifestations,most associated concomitant diseases,morphology and pathologic types of neoplasms,and characteristics of anatomical distribution of the lesions.Results 123 articles (including 6548 patients) were collected and analyzed.There was a tendency for the older patients to suffer from pancreatic IPMNs,and males were slightly more than females.In the three types of morphoIogy,the most common was the branchduct type.Pancreatic IPMNs may appear at any part of the pancreas.The pancreatic head was the most common,followed by the pancreatic body-tail and the diffuse distribution.In all the patients,malignancy was up to half.The main clinical manifestations of pancreatic IPMNs were complete lack of specificity.Upper abdominal pain,weight loss and jaundice were common.Conclusions Particular attention should be paid to the recognition and identification of IPMNs of pancreas as the lesion has nonspecific clinical manifestations.Clinically,treatment should be based on a comprehensive analysis of the clinical features combined with the patient's general status and intent.