CAJ | 학술논문

目的探讨胰腺转移性肿瘤的诊断、治疗及预后.方法回顾收治的32例胰腺转移性肿瘤临床病理资料,以Kaplan Meier法进行单因素分析,log-rank检验进行组间差异比较.结果原发肿瘤为肺癌9例、肾癌6例、胃癌5例、其他肿瘤12例.转移性肿瘤行手术治疗(8例)中位生存期15.5个月,氩氦刀治疗(3例)中位生存期18个月,姑息短路治疗(9例)中位生存期8个月,局部放疗(3例)中位生存期6个月,无治疗(9例)中位生存期5个月.单因素分析显示:转移性肿瘤的预后与原发肿瘤的种类、原发肿瘤的治疗方式、出现胰腺转移的时间间隔、是否为局限性胰腺转移及胰腺局部治疗方式相关.结论胰腺转移性肿瘤临床少见.根据原发肿瘤不同,选择恰当的患者对转移性胰腺肿瘤进行积极的手术可以明显延长生存期.氩氦刀作为一种新型微创、靶向、免疫治疗手段值得进一步研究.
목적 탐토이선전이성종류적진단、치료급예후.방법 회고수치적32례이선전이성종류림상병리자료,이Kaplan Meier법진행단인소분석,log-rank검험진행조간차이비교.결과 원발종류위폐암9례、신암6례、위암5례、기타종류12례.전이성종류행수술치료(8례)중위생존기15.5개월,아양도치료(3례)중위생존기18개월,고식단로치료(9례)중위생존기8개월,국부방료(3례)중위생존기6개월,무치료(9례)중위생존기5개월.단인소분석현시:전이성종류적예후여원발종류적충류、원발종류적치료방식、출현이선전이적시간간격、시부위국한성이선전이급이선국부치료방식상관.결론 이선전이성종류림상소견.근거원발종류불동,선택흡당적환자대전이성이선종류진행적겁적수술가이명현연장생존기.아양도작위일충신형미창、파향、면역치료수단치득진일보연구.
Objective To study the clinicopathological characteristics and the prognostic factors in metastatic pancreatic tumor.Methods The clinical data of 32 patients with metastatic pancreatic tumors were retrospectively analyzed.The survival of the patients were evaluated with the KaplanMeier method.Univariate analysis was done by log-rank test.Results The primary foei of these32 patients included:9 lung cancer,6 renal cell carcinoma,5 gastric cancer,12 others.The median survival was 15.5 months in the radical surgery group (n 8),18 months in the cryosurgery group(n=3),8 months in the group with palliative bypass operation (n=9),6 months in the group with local radiotherapy (n=3),and 5 months in the group without treatment (n=9).Univariable analysis revealed the type of primary tumor,treatment of the primary tumor,interval between diagnosis of primary tumor and pancreatic metastases,localized pancreatic metastasis,and treatment of the metastatic pancreatic tumor were associated with prognosis.Conclusions Metastatic pancreatic tumors are rare.Long term survival can be achieved with pancreatic resection in a highly selected subset of patients according to the type of primary tumor.Therapeutic cryosurgery as a new minimally invasive,targeted and immunologic method needs to be further evaluated.