CAJ | 학술논문

目的探讨胰腺神经内分泌癌(PNEC)的临床病理学特征与外科治疗效果.方法回顾性分析长海医院1998年1月至2011年11月手术治疗的60例PNEC患者的临床病理学特征与外科治疗效果,采用log-rank检验比较根治性切除组与姑息性手术组患者生存情况之间的差异.结果 60例患者中行根治性切除者50例,行姑息性手术者10例.根治性切除组5年生存率达51.5％,非根治性切除组的3年生存率为10.0％.根治性切除组的中位生存时间为61个月,非根治性切除组的中位生存时间为16个月(P＜0.01).结论手术是治疗PNEC的首选方法,根治性切除组比姑息性切除组生存时间长.
목적 탐토이선신경내분비암(PNEC)적림상병이학특정여외과치료효과.방법 회고성분석장해의원1998년1월지2011년11월수술치료적60례PNEC환자적림상병이학특정여외과치료효과,채용log-rank검험비교근치성절제조여고식성수술조환자생존정황지간적차이.결과 60례환자중행근치성절제자50례,행고식성수술자10례.근치성절제조5년생존솔체51.5％,비근치성절제조적3년생존솔위10.0％.근치성절제조적중위생존시간위61개월,비근치성절제조적중위생존시간위16개월(P＜0.01).결론 수술시치료PNEC적수선방법,근치성절제조비고식성절제조생존시간장.
Objective To investigate the clinicopathological features and the effect of surgical treatment on pancreatic neuroendocrine carcinoma (PNEC).Methods The clinical data of 60 patients with PNEC treated from January 1998 to November 2011 at Changhai Hospital were retrospectively analyzed.The differences in survival rates and the duration of survival between the radical resection group and the palliative surgery group were compared with the log-rank test.Results Of 60 patients,50 received radical resection and 10 palliative surgery.The 5-year overall survival for the radical resection group was 51.5％.The overall survival at 3 years for the palliative surgery group was 10.0％.The median survival was 61 months for the radical resection group and 16 months for the palliative surgery group (P ＜ 0.01).Conclusions Surgery is the first choice of treatment for PNEC.The survival of the radical resection group was significantly longer than that of the palliative surgery group.